Intervention Review

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Interventions for the treatment of Paget's disease of the vulva

  1. Katharine A Edey1,*,
  2. Ernest Allan2,
  3. John B Murdoch3,
  4. Susan Cooper4,
  5. Andrew Bryant5

Editorial Group: Cochrane Gynaecological, Neuro-oncology and Orphan Cancer Group

Published Online: 26 OCT 2013

Assessed as up-to-date: 2 SEP 2013

DOI: 10.1002/14651858.CD009245.pub2


How to Cite

Edey KA, Allan E, Murdoch JB, Cooper S, Bryant A. Interventions for the treatment of Paget's disease of the vulva. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD009245. DOI: 10.1002/14651858.CD009245.pub2.

Author Information

  1. 1

    Royal Devon and Exeter Hospital, Exeter, UK

  2. 2

    Christie Hospital, Manchester, UK

  3. 3

    St Michael's Hospital, Department of Gynaecological Oncology, Bristol, UK

  4. 4

    Churchill Hospital, Department of Dermatology, Oxford, UK

  5. 5

    Newcastle University, Institute of Health & Society, Newcastle upon Tyne, UK

*Katharine A Edey, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK. katharineedey@hotmail.com. katharineedey@hotmail.com.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 26 OCT 2013

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References

References to studies excluded from this review

  1. References to studies excluded from this review
  2. References to studies awaiting assessment
  3. Additional references
Bakalianou 2008 {published data only}
  • Bakalianou K, Salakos N, Iavazzo C, Paltoglou G, Papadias K, Gregoriou O, et al. Paget's disease of the vulva. A ten-year experience. European Journal of Gynecologic Oncology 2008;29(4):368-70.
Black 2007 {published data only}
  • Black D, Tornos C, Soslow RA, Awtrey CS, Barakat RR, Chi DS. The outcomes of patients with positive margins after excision for intraepithelial Paget's disease of the vulva. Gynaecologic Oncology 2007;104:547-50.
Crawford 1999 {published data only}
  • Crawford D, Nimmo M, Clement PB, Thomson T, Benedet JL, Miller D, et al. Prognostic factors in Paget's disease of the vulva: a study of 21 cases. International Journal of Gynaecological Pathology 1999;18(4):351-9.
Curtin 1990 {published data only}
Fanning 1999 {published data only}
  • Fanning JDO, Lambert HC, Hale TM, Morris PC, Schuerch C. Paget's disease of the vulva: prevalence of associated vulvar adenocarcinoma, invasive Paget's disease and recurrence after surgical excision. American Journal of Obstetrics and Gynecology 1999;180:24-7.
Feuer 1990 {published data only}
Fishman 1995 {published data only}
Goldblum 1997 {published data only}
Koss 1968 {published data only}
Lee 1977 {published data only}
Lee 2010 {published data only}
  • Lee CW, Song MJ, Lee SH, Kim JH, Lee SJ, Lee KH, et al. Clinicopathologic analysis of extramammary Paget's disease. European Journal of Gynecological Oncology 2010;32(1):34-6.
Louis-Sylvestre 2001 {published data only}
  • Louis-Sylvestre C, Haddad B, Paniel BJ. Paget's disease of the vulva-results of different conservative treatments. European Journal of Obstetrics, Gynaecology and Reproductive Biology 2001;99:253-5.
Martorell-Calatayud 2009 {published data only}
  • Martorell-Calatayud A, Sanmartín-Jiménez O, Escutia-Muñoz B, Guillén-Barona C. Imiquimod topical at 5% as therapeutic alternative in primary extramammary Paget's disease [Imiquimod tópico al 5% como alternativa terapéutica en la enfermedad de Paget extramamaria primaria]. Piel 2009;10:568-9.
Molinie 1993 {published data only}
  • Molinie V, Paniel BJ, Lessana-Leibowitch M, Moyal-Barracco M, Pelisse M, Escande JP. Paget disease of the vulva: 36 cases [Maladie de Paget vulvaire: 36 cas]. Annales de Dermatologie et de Vénéréologie 1993;120:522-7.
Niikura 2006 {published data only}
Parker 2000 {published data only}
  • Parker LP, Parker JR, Bodurka-Bevers D, Deavers M, Bevers MW, Shen-Gunther J, et al. Paget's disease of the vulva: pathology, pattern of involvement, and prognosis. Gynaecologic Oncology 2000;77:183-9.
Parmley 1975 {published data only}
Petkovic 2006 {published data only}
  • Petkovic S, Jeremic K, Vidakovic S, Jeremic J, Lazovic G. Paget's disease of the vulva - a review of our experience. European Journal of Gynaecological Oncology 2006;27(6):611-12.
Pierie 2003 {published data only}
  • Pierie JEN, Choudry U, Muzikansky A, Finkelstein DM, Ott MJ. Prognosis and management of extramammary Paget's disease and the association with secondary malignancies. Journal of American College of Surgeons 2003;196:45-50.
Roh 2010 {published data only}
Shaco-Levy 2010 {published data only}
  • Shaco-Levy R, Bean SM, Vollmer RT, Jewell E, Jones EL, Valdes CL, et al. Paget disease of the vulva: a study of 56 cases. European Journal of Obstetrics & Gynecology and Reproductive Biology 2010;149:86-91.
  • Shaco-Levy R, Bean SM, Vollmer RT, Papalas JA, Bentley RC, Selim MA, et al. Paget disease of the vulva: a histologic study of 56 cases corelating pathologic features and disease course. International Journal of Gynecological Pathology 2010;29(1):69-78.
Shingleton 1970 {published data only}
Stacy 1986 {published data only}
  • Stacy D, Burrell MO, Franklin EW. Extramammary Paget's disease of the vulva and anus: use of intraoperative frozen-section margins. American Journal of Obstetrics and Gynecology 1986;155:519-23.
Strempel 1958 {published data only}
  • Strempel R. Study on Paget's disease of the vulva [Beitrag zum morbus paget der vulva]. Dermatologische Wochenschrif 1958;138(46):1241-52.
Tanaka 2009 {published data only}
  • Tanaka VDA, Sanches JA, Torezan L, Niwa AB, Neto CF. Mammary and extramammary Paget's disease: a study of 14 cases and therapeutic difficulties. Clinics (Sao Paolo) 2009;64(6):599-606.
Tebes 2002 {published data only}
Wang 2003 {published data only}
  • Wang LC, Blanchard A, Judge DE, Lorincz AA, Medenica MM, Busbey S. Successful treatment of recurrent extramammary Paget's disease of the vulva with topical imiquimod 5% cream. Journal of the American Academy of Dermatology 2003;49(4):769-72.
Zawislak 2004 {published data only}

References to studies awaiting assessment

  1. References to studies excluded from this review
  2. References to studies awaiting assessment
  3. Additional references
Fontanelli 2013 {published data only}
  • Fontanelli R, Papadia A, Martinelli F, Lorusso D, Grijuela B, Merola M, et al. Photodynamic therapy with M-ALA as non surgical treatment option in patients with primary extramammary Paget's disease. Journal of Clinical Oncology 2013;130:90-4.
Lu 1999 {published data only}
  • Lu H, Zhu G. Clinicopathologic and immunohistochemical features of vulvar Paget diseases. Chinese Journal of Obstetrics and Gynaecology 1999;34(3):156-8.
Shrestha 2010 {published data only}
  • Shrestha E. Clinical analysis of 13 cases of vulvar Paget's disease. Journal of Chinese Clinical Medicine 2010;5(6):322-5.

Additional references

  1. References to studies excluded from this review
  2. References to studies awaiting assessment
  3. Additional references
Bertozzi 2009
  • Bertozzi S, Londero AP, Fruscalzo A, Marchesoni D, Lellé RJ. Paget disease of the vulva: resolution after local treatment with imiquimod - report of a case and review of the literature. Gynakol Geburtshilfliche Rundsch 2009;49(4):326-30.
Bucher 1997
  • Bucher HC, Guyatt GH, Griffith LE, Walter SD. The results of direct and indirect treatment comparisons in meta-analysis of randomized controlled trials. Journal of Clinical Epidemiology 1997;50(6):683-91.
CTCAE 2006
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Deeks 2001
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DerSimonian 1986
Hatch 2008
Heymann 1993
Higgins 2003
Higgins 2011
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Higgins 2011a
  • Higgins JPT, Altman DG, Sterne JAC. Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Kanitakis 2007
Li 2010
  • Li Q, Gao T, Jiao B, Qi X, Long H, Qiao H, et al. Long-term follow-up of in-situ extramammary Paget's disease in Asian skin types IIII/V treated with photodynamic therapy. Acta Dermato-Venereologica 2010;90:159-64.
Luk NM 2003
Maclean 1995
Moreno-Arias 2003
  • Moreno-Arias GA, Conill C, Sola-Casas MA, Mascaro-Galy JM, Grimalt R. Radiotherapy for in situ extramammary Paget disease of the vulva. Journal of Dermatological Treatment 2003;14(2):119-23.
Nardelli 2011
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Parmar 1998
Preti 2003
  • Preti M, Micheletti L, Massobrio M, Ansai S, Wilkinson EJ. Vulvar Paget disease: one century after first reported. Journal of Lower Genital Tract Disease 2003;7(2):122-35.
Raspagliesi 2006
  • Raspagliesi F, Fontanelli R, Rossi G, Ditto A, Solima E, Hanozet F, et al. Photodynamic therapy using a methyl ester of 5-aminolevulinic acid in recurrent Paget's disease of the vulva: a pilot study. Gynecologic Oncology 2006;103(2):581-6.
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  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
Sendagorta 2010
  • Sendagorta E, Herranz P, Feito M, Ramírez P, Floristán U, Feltes R, et al. Successful treatment of three cases of primary extramammary Paget's disease of the vulva with Imiquimod - proposal of a therapeutic schedule. Journal of the European Academy of Dermatology and Venereology 2010;24(4):490-2.
Shieh 2002
Tonguc 2011
  • Tonguc E, Gungor T, Var T, Ozat M, Sahin I, Sirvan L. Treatment of recurrent vulvar Paget disease with imiquimod cream: a case report and review of the literature. Archives of Gynecology and Obstetrics 2011;283(1):97-101.
Tsutsumida 2003
Valentine 1992
Watanabe 2002
Wilkinson 2002
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