Intervention Protocol

Hyperbaric oxygen for term newborns with hypoxic ischemic encephalopathy

  1. Tao Xiong1,
  2. Honghao Li2,
  3. Jing Zhao1,
  4. Wenbin Dong3,
  5. Yi Qu1,
  6. Taixiang Wu4,
  7. Dezhi Mu1,*

Editorial Group: Cochrane Neonatal Group

Published Online: 10 AUG 2011

Assessed as up-to-date: 15 MAY 2011

DOI: 10.1002/14651858.CD009248

How to Cite

Xiong T, Li H, Zhao J, Dong W, Qu Y, Wu T, Mu D. Hyperbaric oxygen for term newborns with hypoxic ischemic encephalopathy (Protocol). Cochrane Database of Systematic Reviews 2011, Issue 8. Art. No.: CD009248. DOI: 10.1002/14651858.CD009248.

Author Information

  1. 1

    West China Second University Hospital, West China Women's and Children's Hospital, Department of Pediatrics, Chengdu, Sichuan, China

  2. 2

    West China Medical School, Department of Evidence-Based Medicine, Chengdu, Sichuan Province, China

  3. 3

    West China Hospital, Sichuan University, Chinese Cochrane Centre, Chinese Evidence-Based Medicine Centre, Chengdu, Sichuan, China

  4. 4

    West China Hospital, Sichuan University, Chinese Cochrane Centre, Chinese Clinical Trial Registry, Chinese Evidence-Based Medicine Centre, INCLEN Resource and Training Centre, Chengdu, Sichuan, China

*Dezhi Mu, Department of Pediatrics, West China Second University Hospital, West China Women's and Children's Hospital, No. 17, Section Three, Ren Min Nan Lu Avenue, Chengdu, Sichuan, 610041, China. dezhimu@yahoo.com.

Publication History

  1. Publication Status: New
  2. Published Online: 10 AUG 2011

SEARCH

 

Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

The objective of this review is to determine the effects of therapeutic HBO (with or without hypothermia) on death and long-term neurodevelopmental disabilities in term newborn infants with HIE. Furthermore, the short-term medical effects and side effects of HBO will be studied.

Primary comparisons:

  1. HBO versus supportive care;
  2. HBO versus hypothermia therapy;
  3. HBO plus hypothermia versus hypothermia alone;
  4. HBO plus erythropoietin versus erythropoietin alone.

Subgroup analyses were planned on the basis of:

  1. severity of HIE (mild, moderate, severe) (Sarnat 1976; Finer 1981);
  2. the therapeutic time window, by timing of commencement of the intervention (< 6 hours versus 6 hours to 7 days versus > 7 days);
  3. the peak pressure of HBO (< 2 ATA versus > 2ATA);
  4. the number of courses of HBO (single course versus multiple courses).