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Hyperbaric oxygen for term newborns with hypoxic ischemic encephalopathy

  • Protocol
  • Intervention

Authors

  • Tao Xiong,

    1. West China Second University Hospital, West China Women's and Children's Hospital, Department of Pediatrics, Chengdu, Sichuan, China
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  • Honghao Li,

    1. West China Medical School, Department of Evidence-Based Medicine, Chengdu, Sichuan Province, China
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  • Jing Zhao,

    1. West China Second University Hospital, West China Women's and Children's Hospital, Department of Pediatrics, Chengdu, Sichuan, China
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  • Wenbin Dong,

    1. West China Hospital, Sichuan University, Chinese Cochrane Centre, Chinese Evidence-Based Medicine Centre, Chengdu, Sichuan, China
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  • Yi Qu,

    1. West China Second University Hospital, West China Women's and Children's Hospital, Department of Pediatrics, Chengdu, Sichuan, China
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  • Taixiang Wu,

    1. West China Hospital, Sichuan University, Chinese Cochrane Centre, Chinese Clinical Trial Registry, Chinese Evidence-Based Medicine Centre, INCLEN Resource and Training Centre, Chengdu, Sichuan, China
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  • Dezhi Mu

    Corresponding author
    1. West China Second University Hospital, West China Women's and Children's Hospital, Department of Pediatrics, Chengdu, Sichuan, China
    • Dezhi Mu, Department of Pediatrics, West China Second University Hospital, West China Women's and Children's Hospital, No. 17, Section Three, Ren Min Nan Lu Avenue, Chengdu, Sichuan, 610041, China. dezhimu@yahoo.com.

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Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

The objective of this review is to determine the effects of therapeutic HBO (with or without hypothermia) on death and long-term neurodevelopmental disabilities in term newborn infants with HIE. Furthermore, the short-term medical effects and side effects of HBO will be studied.

Primary comparisons:

  1. HBO versus supportive care;

  2. HBO versus hypothermia therapy;

  3. HBO plus hypothermia versus hypothermia alone;

  4. HBO plus erythropoietin versus erythropoietin alone.

Subgroup analyses were planned on the basis of:

  1. severity of HIE (mild, moderate, severe) (Sarnat 1976; Finer 1981);

  2. the therapeutic time window, by timing of commencement of the intervention (< 6 hours versus 6 hours to 7 days versus > 7 days);

  3. the peak pressure of HBO (< 2 ATA versus > 2ATA);

  4. the number of courses of HBO (single course versus multiple courses).

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