Intervention Review

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Cannabinoids for epilepsy

  1. David Gloss1,*,
  2. Barbara Vickrey2

Editorial Group: Cochrane Epilepsy Group

Published Online: 5 MAR 2014

Assessed as up-to-date: 9 SEP 2013

DOI: 10.1002/14651858.CD009270.pub3


How to Cite

Gloss D, Vickrey B. Cannabinoids for epilepsy. Cochrane Database of Systematic Reviews 2014, Issue 3. Art. No.: CD009270. DOI: 10.1002/14651858.CD009270.pub3.

Author Information

  1. 1

    Neurology MC14-05, Danville, USA

  2. 2

    University of California, Department of Neurology, Los Angeles, California, USA

*David Gloss, Neurology MC14-05, 100 N Academy Ave, Geisinger Medical Center, Danville, PA 17821, USA. davy.gloss@gmail.com.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 5 MAR 2014

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Ames 1985 {published data only}
Cunha 1980 {published data only}
Mechoulam 1978 {published data only}
Trembly 1990 {published data only (unpublished sought but not used)}
  • Trembly B, Sherman M. Double-blind clinical study of cannabidiol as a secondary anticonvulsant. Marijuana '90 International Conference on Cannabis and Cannabinoids;1990 July 8-11; Kolympari, Crete. International Association for Cannabinoid Medicines, 1990:section 2-page 5.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Brust 1992 {published data only}
  • Brust JC, Ng SK, Hauser AW, Susser M. Marijuana use and the risk of new onset seizures. Transactions of the American Clinical and Climatological Association 1992;103:176-81.
Carlini 1981 {published data only}
Consroe 1975 {published data only}
Consroe 1992 {published data only (unpublished sought but not used)}
  • Consroe PF, Sandyk R. Potential role of cannabinoid for therapy of neurological disorders. In: L Murphy, A Bartke editor(s). Maijuana/Cannabinoids Neurobiology and Neurophysiology. Boca Raton: CRC Press, 1992:459-524.
Corral 2001 {published data only}
  • Corral VL. Differential effects of medical marijuana based on strain and route of administration: a three-year observational study. Journal of Cannabis Therapeutics 2001;1(3/4):43-59.
Davis 1949 {published data only}
  • Davis JP, Ramsey HH. Anti-epileptic action of marijuana-active substances. Federation Proceedings 1949;8:167.
Ellison 1990 {published data only}
Feeney 1976 {published data only}
Gieringer 2002 {published data only}
  • Gieringer D. Medical Use of Cannabis: Experience in California. In: F Grotenherman, E Russo editor(s). Cannabis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential. New York, NY: The Haworth Press, 2002:143-51.
Gordon 2001 {published data only}
Grinspoon 1997 {published data only}
  • Grinspoon L, Bakalar JB. Marihuana, the forbidden medicine. New Haven, CT: Yale University Press, 1997.
Gross 2004 {published data only}
Grotenherman 2003 {published data only}
  • Grotenherman F, Schnelle M. Survey on the Medical Use of Cannabis and THC in Germany. Journal of Cannabis Therapeutics 2003;3(2):17-39.
Keeler 1967 {published data only}
Lorenz 2003 {published data only}
  • Lorenz R. Experiences with THC-treatment in children and adolescents. IACM 2nd Conference on Cannabinoids in Medicine. Koeln, Germany: International Association for Cannabis as Medicine, 2003:6.
Lorenz 2004 {published data only}
Lutz 2008 {published data only}
Mortati 2007 {published data only}
  • Mortati K, Dworetzky B, Devinsky O. Marijuana: an effective treatment in partial epilepsy? A case report and review of the literature. Reviews in Neurological Diseases 2007;4(2):103-6.
Ng 1990 {published data only}
Perez-Reyes 1974 {published data only}
  • Perez-Reyes M, Wingfield M. Cannabidiol and electroencephalographic epileptic activity. JAMA 1974;230(12):1635.
Petro 1997 {published data only}
  • Petro D. Seizure Disorders. In: ML Mathre editor(s). Cannabis in Medical Practive. Jefferson, NC: McFarland & Co, Inc., 1997:125-8.
Pijlman 2005 {published data only}

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Annegers 1999
Buckmaster 1997
Buckmaster 2002
  • Buckmaster PS, Zhang GF, Yamawaki R. Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuit. Journal of Neuroscience 2002;22(15):6650-8.
Dudek 1997
  • Dudek FE, Spitz M. Hypothetical mechanisms for the cellular and neurophysiologic basis of secondary epileptogenesis: proposed role of synaptic reorganization. Journal of Clinical Neurophysiology 1997;14(2):90-101.
EMCDDA 2002
  • European Monitoring Centre for Drugs and Drug Addiction. Medicinal cannabis and derivatives: a legal analysis of the options, their limitations, and current practice in the EU. www.eldd.emcdda.org/databases/eldd_comparative_analyses.cfm (date accessed March 15, 2011) 2002.
Feigenbaum 1989
  • Feigenbaum JJ, Bergmann F, Richmond SA, Mechoulam R, Nadler V, Kloog Y, et al. Nonpsychotropic cannabinoid as a functional N-methy-D-aspartate receptor blocker. Proceedings of the National Academy of Sciences of the United States 1989;86(23):9584-7.
Felder 1998
Franck 1995
Gowers 1881
  • Gowers WR. Epilepsy and Other Chronic Convulsive Disorders. London: Churchill, 1881.
Hauser 1993
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Hoffman 2010
Howlett 2004
  • Howlett AC, Breivogel CS, Childers SR, Deadwyler SA, Hampson RE, Porrino LJ. Cannabinoid physiology and pharmacology: 30 years of progress. Neuropharmacology 2004;47(S1):345-58.
Juul-Jensen 1983
Kirkham 2010
  • Kirkham JJ, Dwan KM, Altman DG, Gamble C, Dodd S, Smyth R, et al. The impact of outcome reporting bias in randomised controlled trials on a cohort of systematic reviews. BMJ 2010;340:c365.
Kwan 2000
Kwan 2010
Lefebvre 2011
  • Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
MacDonald 2000
  • MacDonald BK, Cockerell OC, Sander JWAS, Shorvon SD. The incidence and lifetime prevalence of neurologic disorders in a prospective community-based study in the UK. Brain 2000;123(4):665-75.
Marsicano 2003
Matsuda 1990
Mechoulam 1970
Mechoulom 2007
Mohanraj 2006
Munro 1993
Murray 1994
  • Murray CJL, Lopez JD. Global Comparative Assessment in the Health Sector. 1st Edition. Geneva: World Health Organization, 1994.
Natasuka 2003
Olafsson 2005
  • Olafsson E, Ludvigsson P, Gudmundsson G, Hesdorffer D, Kjartansson O, Hauser WA. Incidence of unprovoked seizures and epilepsy in Iceland and an assessment of the epilepsy syndrome classification: a prospective study. Lancet Neurology 2005;4(10):627-34.
Prevost 2000
Radwan 2009
  • Radwan MM, Elsohly MA, Slade D, Ahmed SA, Khan IA, Ross SA. Biologically active cannabinoids from high-potency Cannabis sativa. Journal of Natural Products 2009;72:906-11.
Razdan 1983
RevMan 2011 [Computer program]
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011.
Song 1993
Sutula 1989
Wilson 2001
Winokur 2004

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Gloss 2012