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Intervention Review

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Autologous serum eye drops for dry eye

  1. Qing Pan1,2,*,
  2. Adla Angelina3,
  3. Andrea Zambrano4,
  4. Michael Marrone5,
  5. Walter J Stark4,
  6. Thomas Heflin4,
  7. Li Tang6,
  8. Esen K Akpek4

Editorial Group: Cochrane Eyes and Vision Group

Published Online: 27 AUG 2013

Assessed as up-to-date: 15 APR 2013

DOI: 10.1002/14651858.CD009327.pub2


How to Cite

Pan Q, Angelina A, Zambrano A, Marrone M, Stark WJ, Heflin T, Tang L, Akpek EK. Autologous serum eye drops for dry eye. Cochrane Database of Systematic Reviews 2013, Issue 8. Art. No.: CD009327. DOI: 10.1002/14651858.CD009327.pub2.

Author Information

  1. 1

    Johns Hopkins University School of Medicine, Wilmer Eye Institute, Baltimore, MD, USA

  2. 2

    Zhejiang Provincial People's Hospital, Department of Ophthalmology, Hangzhou, Zhejiang, China

  3. 3

    University of Mississippi School of Medicine, Department of Pathology, Jackson, MS, USA

  4. 4

    Johns Hopkins University School of Medicine, Department of Ophthalmology, Baltimore, MD, USA

  5. 5

    Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, Baltimore, Maryland, USA

  6. 6

    Affiliated Hospital of Guiyang Medical College, Ophthalmology Department, Guiyang, Guizhou Province, China

*Qing Pan, Wilmer Eye Institute, Johns Hopkins University School of Medicine, 327 Maumenee Bldg, 600 N. Wolfe St., Baltimore, MD, 21287-9238, USA. panqing@hotmail.com.

Publication History

  1. Publication Status: New
  2. Published Online: 27 AUG 2013

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[Figure 1]
Figure 1. Results from searching for studies for inclusion in the review
[Figure 2]
Figure 2. Methodological quality summary: risk of bias review authors' judgements about each risk of bias item for each included study.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Autologous serum (20%) versus artificial tears, Outcome 1 Participant-reported symptoms (severe dry eye).
[Analysis 1.2]
Analysis 1.2. Comparison 1 Autologous serum (20%) versus artificial tears, Outcome 2 Rose Bengal (severe dry eye).
[Analysis 1.3]
Analysis 1.3. Comparison 1 Autologous serum (20%) versus artificial tears, Outcome 3 Rose Bengal (post-LASIK dry eye).
[Analysis 1.4]
Analysis 1.4. Comparison 1 Autologous serum (20%) versus artificial tears, Outcome 4 Fluorescein (severe dry eye).
[Analysis 1.5]
Analysis 1.5. Comparison 1 Autologous serum (20%) versus artificial tears, Outcome 5 Schirmers I test (severe dry eye).
[Analysis 1.6]
Analysis 1.6. Comparison 1 Autologous serum (20%) versus artificial tears, Outcome 6 TBUT (severe dry eye).
[Analysis 1.7]
Analysis 1.7. Comparison 1 Autologous serum (20%) versus artificial tears, Outcome 7 TBUT (post-LASIK dry eye).
[Analysis 2.1]
Analysis 2.1. Comparison 2 Autologous serum (20%) versus saline solution, Outcome 1 Participant-reported symptoms (severe dry eye).
[Analysis 2.2]
Analysis 2.2. Comparison 2 Autologous serum (20%) versus saline solution, Outcome 2 Rose Bengal (severe dry eye).
[Analysis 2.3]
Analysis 2.3. Comparison 2 Autologous serum (20%) versus saline solution, Outcome 3 Fluorescein (severe dry eye).
[Analysis 2.4]
Analysis 2.4. Comparison 2 Autologous serum (20%) versus saline solution, Outcome 4 Schirmers I test (with anesthesia) (severe dry eye).
[Analysis 2.5]
Analysis 2.5. Comparison 2 Autologous serum (20%) versus saline solution, Outcome 5 TBUT (severe dry eye).