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Intervention Review

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Autologous serum eye drops for dry eye

  1. Qing Pan1,2,*,
  2. Adla Angelina3,
  3. Andrea Zambrano4,
  4. Michael Marrone5,
  5. Walter J Stark4,
  6. Thomas Heflin4,
  7. Li Tang6,
  8. Esen K Akpek4

Editorial Group: Cochrane Eyes and Vision Group

Published Online: 27 AUG 2013

DOI: 10.1002/14651858.CD009327.pub2


How to Cite

Pan Q, Angelina A, Zambrano A, Marrone M, Stark WJ, Heflin T, Tang L, Akpek EK. Autologous serum eye drops for dry eye. Cochrane Database of Systematic Reviews 2013, Issue 8. Art. No.: CD009327. DOI: 10.1002/14651858.CD009327.pub2.

Author Information

  1. 1

    Johns Hopkins University School of Medicine, Wilmer Eye Institute, Baltimore, MD, USA

  2. 2

    Zhejiang Provincial People's Hospital, Department of Ophthalmology, Hangzhou, Zhejiang, China

  3. 3

    University of Mississippi School of Medicine, Department of Pathology, Jackson, MS, USA

  4. 4

    Johns Hopkins University School of Medicine, Department of Ophthalmology, Baltimore, MD, USA

  5. 5

    Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, Baltimore, Maryland, USA

  6. 6

    Affiliated Hospital of Guiyang Medical College, Ophthalmology Department, Guiyang, Guizhou Province, China

*Qing Pan, Wilmer Eye Institute, Johns Hopkins University School of Medicine, 327 Maumenee Bldg, 600 N. Wolfe St., Baltimore, MD, 21287-9238, USA. panqing@hotmail.com.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 27 AUG 2013

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This is not the most recent version of the article. View current version (28 FEB 2017)

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Kojima 2005a {published and unpublished data}
  • Kojima T, Ishida R, Dogru M, Goto E, Matsumoto Y, Kaido M, et al. The effect of autologous serum eyedrops in the treatment of severe dry eye disease: a prospective randomized case-control study. American Journal Ophthalmology 2005;139(2):242-6.
  • Kojima T, Ishida R, Goto E, Matsumoto Y, Dogru M, Tsubota K. The efficacy of autologous serum eye drops for Keratoconjunctivitis Sicca - A prospective study. Investigative Ophthalmology and Visual Science 2004;45:ARVO E-abstract 3894.
Noda-Tsuruya 2006 {published data only (unpublished sought but not used)}
Tananuvat 2001 {published data only (unpublished sought but not used)}
Urzua 2012 {published data only (unpublished sought but not used)}
  • Urzua CA, Vasquez DH, Huidobro A, Hernandez H, Alfaro J. Randomized double-blind clinical trial of autologous serum versus artificial tears in dry eye syndrome. Current Eye Research 2012;37(8):684-8.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Albegger 1972 {published data only}
  • Albegger KW, Tilz GP. Sjogren's syndrome and its therapy. A therapeutic attempt using antilymphocyte serum [Zum Sjogren-syndrom und seiner behandlung. Ein therapieversuch mit antilymphozytenglobulin]. Zeitschrift Fur Laryngologie, Rhinologie, Otologie Und Ihre Grenzgebiete 1972;51(7):429-37.
Alvarado 2004 {published data only}
  • Alvarado Valero MC, Martinez Toldos JJ, Borras Blasco J, Alminana Alminana A, Perez Ramos JM. Treatment of persistent epithelial defects using autologous serum application [Tratamiento de defectos epiteliales persistentes mediante suero autologo]. Archivos De La Sociedad Espanola De Oftalmologia 2004;79(11):537-42.
Anderson 2004 {published data only}
  • Anderson NG, Regillo C. Ocular manifestations of graft versus host disease. Current Opinion in Ophthalmology 2004;15(6):503-7.
Badami 2009 {published data only}
  • Badami K, McKellar M. Allogeneic serum eye drops-a useful alternative for those unable to be autologous donors. Transfusion. Proceedings of the AABB Annual Meeting and TXPO; 2009 Oct 24 -27; New Orleans (LA). 2009.
Bradley 2008 {published data only}
Brown 2005 {published data only}
  • Brown SM, Bradley JC. The effect of autologous serum eye drops in the treatment of severe dry eye disease: a prospective randomized case-control study. American Journal of Ophthalmology 2005;140(3):565.
Chiang 2007 {published data only}
Craig 2008 {published data only}
Fuchsluger 2005 {published data only}
Geerling 2002 {published data only}
  • Geerling G, Hartwig D. Autologous serum-eye-drops for ocular surface disorders. A literature review and recommendations for their application [Autologe serum-augentropfen zur therapie der augenoberflache eine ubersicht zur wirksamkeit und empfehlungen zur anwendung]. Ophthalmologe 2002;99(12):949-59.
Geerling 2004 {published data only}
Geerling 2008 {published data only}
  • Geerling G, Unterlauft JD, Kasper K, Schrader S, Opitz A, Hartwig D. Autologous serum and alternative blood products for the treatment of ocular surface disorders [Eigenserum und alternative Blutprodukte zur Behandlung von Augenoberflachenerkrankungen]. Ophthalmologe 2008;105(7):623-31.
Harritshoj 2011 {unpublished data only}
  • Harritshoj LH, Hansen MB, Julian HO. Ready-made allogenic serum eye drops for severe dry eye disease. Vox Sanguinis. Proceedings of the 21st Regional Congress of the International Society of Blood Transfusion; 2011 Jun 18-22; Lisbon, Portugal. 2011.
Hyon 2007 {published data only}
Jaksche 2005 {unpublished data only}
  • Jaksche A, Sbeity Z, Domeier E, Fimmers R, Holz F, Loeffler KU. Undiluted versus diluted Autologous Serum Eye Drops (ASED): A prospective, randomized, double-blind study in patients with refractory dry eye-syndrome. Investigative Ophthalmology and Visual Science 2005;46:ARVO E-abstract 2045.
Koffler 2006 {published data only}
Kojima 2005b {published data only}
  • Kojima T, Dogru M, Matsumoto Y, Goto E, Tsubota K. Tear film and ocular surface abnormalities after eyelid tattooing. Ophthalmic Plastic and Reconstructive Surgery 2005;21(1):69-71.
Kojima 2008 {published data only}
  • Kojima T, Higuchi A, Goto E, Matsumoto Y, Dogru M, Tsubota K. Autologous serum eye drops for the treatment of dry eye diseases. Cornea 2008;27(Suppl 1):25-30.
Messmer 2005 {published data only}
Movahedan 2006 {published data only}
  • Movahedan H, Ghassemifar V. Treatment of persistent corneal epithelial defect with autologous serum. Asian Journal of Ophthalmology 2006;8(6):236-41.
Noble 2004 {published data only}
  • Noble BA, Loh RS, MacLennan S, Pesudovs K, Reynolds A, Bridges LR, et al. Comparison of autologous serum eye drops with conventional therapy in a randomised controlled crossover trial for ocular surface disease. British Journal of Ophthalmology 2004;88(5):647–52.
Ogawa 2003 {published data only}
  • Ogawa Y, Okamoto S, Mori T, Yamada M, Mashima Y, Watanabe R, et al. Autologous serum eye drops for the treatment of severe dry eye in patients with chronic graft-versus-host disease. Bone Marrow Transplantation 2003;31(7):579-83.
Poon 2001 {published data only}
  • Poon AC, Geerling G, Dart JK, Fraenkel GE, Daniels JT. Autologous serum eyedrops for dry eyes and epithelial defects: clinical and in vitro toxicity studies. British Journal of Ophthalmology 2001;85(10):1188-97.
Watson 2010 {published data only}
Yoon 2007 {published data only}
  • Yoon KC, Heo H, Im SK, You IC, Kim YH, Park YG. Comparison of autologous serum and umbilical cord serum eye drops for dry eye syndrome. American Journal of Ophthalmology 2007;144(1):86-92.

Additional references

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