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Role of chemotherapy additional to high-dose methotrexate for primary central nervous system lymphoma (PCNSL)

  • Protocol
  • Intervention



This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

The main objective of this Cochrane review is to evaluate the role of additional chemotherapy to HD-MTX in the treatment of immunocompetent PCNSL patients with respect to overall survival (OS), progression-free survival (PFS), response rate, adverse events (AE), treatment-related mortality (TRM) and quality of life (QoL).