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Serological laboratory tests for diagnosis of human leptospirosis in patients presenting with clinical symptoms

  • Protocol
  • Diagnostic

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Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

To determine the diagnostic accuracy of serological tests for diagnosing leptospirosis in patients presenting with compatible clinical symptoms, for example fever or muscle pain, or both.

a) To determine the diagnostic accuracy of laboratory tests (ie, ELISA, dipstick, agglutination test) for diagnosing human leptospirosis in acute patients (0 to 10 days post-onset) and convalescent patients (> 10 days post-onset).

b) To determine the best diagnostic laboratory test for diagnosing human leptospirosis in incidence-related subgroups (high incidence versus low incidence).

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