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High-dose chemotherapy followed by autologous stem cell transplantation for patients with relapsed/refractory Hodgkin lymphoma

  1. Michaela Rancea1,*,
  2. Ina Monsef1,
  3. Bastian von Tresckow2,
  4. Andreas Engert1,
  5. Nicole Skoetz1

Editorial Group: Cochrane Haematological Malignancies Group

Published Online: 20 JUN 2013

Assessed as up-to-date: 1 MAR 2013

DOI: 10.1002/14651858.CD009411.pub2


How to Cite

Rancea M, Monsef I, von Tresckow B, Engert A, Skoetz N. High-dose chemotherapy followed by autologous stem cell transplantation for patients with relapsed/refractory Hodgkin lymphoma. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD009411. DOI: 10.1002/14651858.CD009411.pub2.

Author Information

  1. 1

    University Hospital of Cologne, Cochrane Haematological Malignancies Group, Department I of Internal Medicine, Cologne, Germany

  2. 2

    University Hospital of Cologne, Department I of Internal Medicine, Cologne, Germany

*Michaela Rancea, Cochrane Haematological Malignancies Group, Department I of Internal Medicine, University Hospital of Cologne, Kerpener Str. 62, Cologne, 50924, Germany. michaela.rancea@uk-koeln.de.

Publication History

  1. Publication Status: New
  2. Published Online: 20 JUN 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
BNLI {published data only}
  • Linch DC, Winfield D, Goldstone AH, Moir D. Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. Lancet 1993;341:1051-4.
HDR1 {published data only}
  • Schmitz N, Haverkamp H, Josting A, Carella AM. Long-term results of HD-R1: conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoetic stem cell transplantation in relapsed Hodgkin's disease [abstract]. European Journal of Haematology 2004;73 Suppl 65:57.
  • Schmitz N, Pfistner B, Sieber M, Carella AM. Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin's disease: a randomised trial. Lancet 2002;359:2065-71.
  • Schmitz N, Sextro M, Hasenclever D, Carella A. HD-R1: first results of a randomized trial comparing aggressive chemotherapy with high-dose therapy (HDT) and hematopoietic stem cell transplantation (HSCT) in patients with chemosensitive relapse of Hodgkin's disease (HD). Blood 1997;90(10):115a.
  • Schmitz N, Sextro M, Pfister B, Hasenclever D. High-dose therapy (HDT) followed by hematopoietic stem cell transplantation (HSCT) for relapsed chemosensitive Hodgkin's disease (HD): final results of a randomized GHSG and EBMT trial (HD-R1) [abstract]. Journal of Clinical Oncology 1999;18:2a.
HDR2 {published data only}
  • Engert A, Haverkamp H, Borchmann P, Mueller H. Final results of the hdr2 study - a European multicenter trial in patients with relapsed Hodgkin lymphoma [Abstract no. 0501]. Haematologica 2009;94 Suppl 2:204.
  • German Hodgkin Study Group. Phase III randomized study of induction chemotherapy followed by combination chemotherapy and autologous peripheral blood stem cell transplantation with or without high-dose sequential chemotherapy in patients with relapsed Hodgkin's lymphoma. clinicaltrials.gov/ct2/show/NCT00025636‎.
  • Glossmann JP, Josting A, Pfistner B, Paulus U. A randomized trial of chemotherapy with carmustine, etoposide, cytarabine, and melphalan (BEAM) plus peripheral stem cell transplantation (PBSCT) vs single-agent high-dose chemotherapy followed by BEAM plus PBSCT in patients with relapsed Hodgkin's disease (HD-R2). Annals of Hematology 2009;81(8):424-9.
  • Josting A, Haverkamp H, Borchmann P, Dohner H. Fourth interim analysis of the HD-R2 study - a European multicenter trial for patients with relapsed Hodgkin lymphoma [abstract]. Haematologica 2007;92 Suppl 5:82-3.
  • Josting A, Mapara M, Reiser M, Draube A, et al. Interim analysis of a multicenter phase-II trial using high-dose sequential chemotherapy and autologous stem cell support for relapsed or refractory Hodgkin's and non-Hodgkin's lymphoma. Annals of Hematology 1998;77 Suppl 2:S214.
  • Josting A, Müller H, Borchmann P, Baars JW. Dose intensity of chemotherapy in patients with relapsed Hodgkin's lymphoma. Journal of Clinical Oncology 2010;28:5074-80.
  • Josting A, Rudolph C, Mapara M, Glossmann JP. Cologne high-dose sequential chemotherapy in relapsed and refractory Hodgkin lymphoma: results of a large multicenter study of the German Hodgkin Lymphoma Study Group (GHSG). Annals of Oncology 2005;16(1):116-23.
  • Josting A, Rudolph C, Mapara M, Sieber M, et al. Cologne high-dose sequential chemotherapy in relapsed and refractory Hodgkin lymphoma - a large multicenter pilot study for the prospective randomized HDR-2 trial of the German Hodgkin Lymphoma Study Group (GHSG). Onkologie 2002;25 Suppl 4:195.
  • Josting A, Rudolph C, Mapara M, Sieber M, et al. Cologne high-dose sequential chemotherapy in relapsed and refractory Hodgkin lymphoma results of a large multicenter study for the prospective randomized HDR-2 trial of the German Hodgkin Lymphoma Study Group (GHSG). Blood 2002;100(11 Pt 2).

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Avigdor 2000 {published data only}
  • Avigdor A, Hardan I, Shpilberg O, Raanani P. High-dose chemotherapy and autologous stem cell transplantation for refractory and relapsing Hodgkin's disease as first-line therapy - studies at Sheba Medical Center -Tel Hashomer. Harefuah 2000;139(5-6):174-9.
Bolanos-Meade 2007 {published data only}
  • Bolanos-Meade J, Garrett-Mayer E, Luznik L, Anders V. Induction of autologous graft-versus-host disease: results of a randomized prospective clinical trial in patients with poor risk lymphoma. Biology of Blood & Marrow Transplantation 2007;13(10):1185-91.
Evens 2007 {published data only}
  • Evens AM, Altman JK, Mittal BB, Hou N. Phase I/II trial of total lymphoid irradiation and high-dose chemotherapy with autologous stem-cell transplantation for relapsed and refractory Hodgkin's lymphoma. Annals of Oncology 2007;18(4):679-88.
Ferme 2002 {published data only}
  • Ferme C, Mounier N, Divine M, Brice P. Intensive salvage therapy with high-dose chemotherapy for patients with advanced Hodgkin's disease in relapse or failure after initial chemotherapy: results of the Groupe d'Etudes des Lymphomes de l'Adulte H89 Trial. Journal of Clinical Oncology 2002;20(2):467-75.
Gutierrez-Delgado 2003 {published data only}
  • Gutierrez-Delgado F, Maloney DG, Holmberg LA, Hooper H. High-dose chemotherapy (HDC) and autologous stem cell transplantation (ASCT) for patients with Hodgkin's disease (HD) - a comparison of two HDC regimens. Proceedings of the American Society of Clinical Oncology 2003;20:293a.
Kuruvilla 2004 {published data only}
  • Kuruvilla J, Nagy T, Pintilie M, Saragosa A. Efficiency of stem cell mobilization after salvage chemotherapy with gemcitabine, dexamethasone, cisplatin (GDP) or mini-BEAM in patients with relapsed or refractory Hodgkin's lymphoma. 6th International Symposium on Hodgkin's Lymphoma. 2004.
Morschhauser 2008 {published data only}
  • Morschhauser F, Brice P, Ferme C, Divine M. Risk-adapted salvage treatment with single or tandem autologous stem-cell transplantation for first relapse/refractory Hodgkin's lymphoma: results of the prospective multicenter H96 trial by the GELA/SFGM study group. Journal of Clinical Oncology 2008;26(36):5980-7.
Sweetenham 1997 {published data only}
  • Sweetenham JW, Taghipour G, Milligan D, Blystad AK. High-dose therapy and autologous stem cell rescue for patients with Hodgkin's disease in first relapse after chemotherapy: results from the EBMT. Lymphoma Working Party of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplantation 1997;20(9):745-52.
Van Agthoven 2001 {published data only}
  • Van Agthoven M, Vellenga E, Fibbe WE, Kingma T. Cost analysis and quality of life assessment comparing patients undergoing autologous peripheral blood stem cell transplantation or autologous bone marrow transplantation for refractory or relapsed non-Hodgkin's lymphoma or Hodgkin's disease: a prospective randomised trial. European Journal of Cancer 2001;37(14):1781-9.
Vellenga 2001 {published data only}
  • Vellenga E, Van Agthoven M, Croockewit AJ, Verdonck LF. Autologous peripheral blood stem cell transplantation in patients with relapsed lymphoma results in accelerated haematopoietic reconstitution, improved quality of life and cost reduction compared with bone marrow transplantation: the Hovon 22 study. British Journal of Haematology 2001;114(2):319-26.
Weaver 1996 {published data only}
  • Waever CH, Schwartzberg LS, Upton S, Birch R. Interim analysis of a randomized phase III trial comparing high-dose busulfan, melphalan and thiotepa (BuMeIT) with carmustine, etoposide, cytosine arabinoside and cyclophosphamide (BEAC) followed by peripheral blood stem cell (PBSC) infusion in patients with relapsed Hodgkin's disease (HD). Blood 1996;88(10):289b.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
ACS 2010
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Baetz 2003
  • Baetz T, Belch A, Couban S, Imrie K, Yau J, Myers R, et al. Gemcitabine, dexamethasone and cisplatin is an active and non-toxic chemotherapy regimen in relapsed or refractory Hodgkin's disease: a phase II study by the National Cancer Institute of Canada Clinical Trials Group. Annals of Oncology 2003;14(12):1762-7. [PUBMED: 14630682]
Bertlett 2007
  • Bartlett NL, Niedzwiecki D, Johnson JL, Friedberg JW, Johnson KB, Van Besien K. Gemcitabine, vinorelbine, and pegylated liposomal doxorubicin (GVD), a salvage regimen in relapsed Hodgkin's lymphoma: CALGB 59804. Annals of Oncology 2007;18(6):1071-9.
Bhatia 2005
  • Bhatia S, Robison LL, Francisco L, Carter A, Liu Y, Grant M, et al. Late mortality in survivors of autologous hematopoietic-cell transplantation: report from the Bone Marrow Transplant Survivor Study. Blood 2005;105(11):4215-22.
Bonfante 2001
  • Bonfante V, Viviani S, Devizzi L, Di Russo A, Di Nicola M, Magni M, et al. High-dose ifosfamide and vinorelbine as salvage therapy for relapsed or refractory Hodgkin's disease. European Journal of Haematology 2001;64:51-5. [PUBMED: 11486403]
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Eich 2010
  • Eich HT, Diehl V, Görgen H, Pabst T, Markova J, Debus J, et al. Intensified chemotherapy and dose-reduced involved-field radiotherapy in patients with early unfavourable Hodgkin's lymphoma: final analysis of the German Hodgkin Study Group HD11 trial. Journal of Clinical Oncology 2010;28(27):4199-206.
Engert 2007
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Engert 2009
  • Engert A, Haverkamp H, Borchmann P, Mueller H, Diehl V, Döhner B, et al. Final results of the HD-R2 study - a European multicenter trial in patients with relapsed Hodgkin lymphoma. Haematologica 2009.
Fermé 2002
  • Fermé C, Mounier N, Diviné M, Brice P, Stamatoullas A, Reman O. Intensive salvage therapy with high-dose chemotherapy for patients with advanced Hodgkin's disease in relapse or failure after initial chemotherapy: results of the Groupe d'Etudes des Lymphomes de l'Adulte H89 Trial. Journal of Clinical Oncology 2002;20(2):467-75.
Franklin 2010
  • Franklin J, Eichenauer D, Monsef I, Engert A. Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant neoplasms, overall and progression-free survival. Cochrane Database of Systematic Reviews 2010, Issue 11. [DOI: 10.1002/14651858.CD008814]
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Josting 2010
  • Josting A,  Müller H,  Borchmann P,  Baars JW,  Metzner B,  Döhner H,  et al. Dose intensity of chemotherapy in patients with relapsed Hodgkin's lymphoma. Journal of Clinical Oncology 2010;28(34):5074-80.
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Linch 1993
  • Linch DC, Winfield D, Goldstone AH, Moir D, Hancock B, McMillan A, et al. Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. Lancet. 1993;341(8852):1051-4.
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Moskowitz 2001
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