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Zinc supplements for treating thalassaemia and sickle cell disease

  1. Kye Mon Min Swe1,*,
  2. Adinegara BL Abas1,
  3. Amit Bhardwaj2,
  4. Ankur Barua3,
  5. N S Nair4

Editorial Group: Cochrane Cystic Fibrosis and Genetic Disorders Group

Published Online: 28 JUN 2013

Assessed as up-to-date: 20 JUN 2013

DOI: 10.1002/14651858.CD009415.pub2


How to Cite

Swe KMM, Abas ABL, Bhardwaj A, Barua A, Nair NS. Zinc supplements for treating thalassaemia and sickle cell disease. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD009415. DOI: 10.1002/14651858.CD009415.pub2.

Author Information

  1. 1

    Melaka-Manipal Medical College (MMMC), Department of Community Medicine, Melaka, Malaysia

  2. 2

    Melaka-Manipal Medical College (MMMC), Department of Orthopaedics, Melaka, Melaka, Malaysia

  3. 3

    International Medical University (IMU), Department of Community Medicine, Kuala Lumpur, Malaysia

  4. 4

    Manipal University, Department of Statistics, Manipal, Karnataka, India

*Kye Mon Min Swe, Department of Community Medicine, Melaka-Manipal Medical College (MMMC), Jalan Batu Hampar, Bukit Baru, Melaka, 75150, Malaysia. khmoneminswe@gmail.com.

Publication History

  1. Publication Status: New
  2. Published Online: 28 JUN 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Acrasoy 1987 {published data only}
Bao 2008 {published data only}
  • Bao B, Prasad A, Beck FWJ, Swerdlow PTI. Beneficial effect of zinc supplementation on oxidative stress, cytokines and NF-KB DNA binding in sickle cell disease patients [abstract]. Blood 2006;108(11):Abstract number: 1203.
Gupta 1995 {published data only}
  • Gupta VL, Chaubey BS. Efficacy of zinc therapy in prevention of crisis in sickle cell anemia: a double blind, randomized controlled clinical trial. Journal of the Association of Physicians of India 1995;43(7):467-9.
Prasad 1981 (1) {published data only}
Prasad 1981 (2) {published data only}
  • Prasad AS, Abbasi AA, Rabbani P, Dumouchelle E. Effect of zinc supplementation on serum testosterone level in adult male sickle cell anemia subjects. American Journal of Hematology 1981; Vol. 10, issue 2:119-27. [MEDLINE: 81204397]
Prasad 1999 {published data only}
  • Prasad AS, Beck FW, Kaplan J, Chandrasekar PH, Ortega J, Fitzgerald JT, et al. Effect of zinc supplementation on incidence of infections and hospital admissions in sickle cell disease (SCD). American Journal of Hematology 1999;61(3):194-202.
Rashidi 2011 {published data only}
  • Rashidi M,  Aboomardani M,  Rafraf M,  Arefhosseini SR,  Keshtkar A,  Joshaghani H. Effects of vitamin E and zinc supplementation on antioxidants in beta thalassemia major patients. Iranian Journal of Pediatrics 2011;21(1):8-14.
Serjeant 1970 {published data only}
  • Serjeant GR, GRE, GMC. Oral zinc sulphate in sickle-cell ulcers. Lancet 1970; Vol. 2, issue 7679:891-2. [MEDLINE: 71010522]
Zemel 2002 {published data only}
  • Fung E, Kawchak D, Zemel B, Ohene-Frempong K, Stallings V. Plasma zinc is not a sensitive indicator of zinc status in children with sickle cell disease [abstract]. Proceedings of the National Sickle Cell Disease Program Annual Meeting; 2001 April 2001:Abstract no: 82.
  • Zemel BS, Kawchak DA, Fung EB, Ohene-Frempong K, Stallings VA. Effect of zinc supplementation on growth and body composition in children with sickle cell disease. American Journal of Clinical Nutrition 2002;75(2):300-7.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Mehdizadeh 2008 {published data only}
Prasad 1975 {published data only}
Prasad 1983a {published data only}
Tschumi 1981 {published data only}
  • Tschumi P, Floersheim GL. Tolerance of large doses of oral zinc sulfate [Zur Vertraglichkeit von hochdosiertem peroralem Zinksulfat.]. Schweizerische Medizinische Wochenschrift 1981; Vol. 111, issue 42:1573-7. [MEDLINE: 82084437]

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
NCT00459732 {published data only}
  • Fung EB. Zinc & Bone Health in Thalassemia: The Think Zinc Study (ThinkZn). clinicaltrials.gov (accessed 20 June 2013).

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Aggett 1995
Arcasoy 1987
Bennekou 2001
  • Bennekou P, de Franceschi L, Pedersen O, Lian L, Asakura T, Evans G, et al. Treatment with NS3623, a novel Cl-conductance blocker,ameliorates erythrocyte dehydration in transgenic SAD mice: a possible new therapeutic approach for sickle cell disease. Blood 2001;97(5):1451-7.
Bhatangar 2004
  • Bhatangar S, Natchu UC. Zinc in child health and disease. Indian Journal of Paediatrics 2004;71(11):991-5.
Daeschner 1981
  • Daeschner CW 3rd, Matustik MC, Carpentieri U, Haggard ME. Zinc and growth in patients with sickle cell disease. Journal of Pediatrics 1981;98(5):778-80.
Firkin 1989
  • Firkin F, Chesterman C, Peninton D, Rush B. de Gruchy's Clinical Haematology in Medical Practice. 5th Edition. Oxford: Blackwell Scientific Publication, 1989.
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org 2011.
Mahyar 2010
  • Mahyar A. Zinc and copper status in children with beta-thalassemia major. Iranian Journal of Pediatrics 2010;20(3):297-302.
Nagalla 2010
Phebus 1988
Prasad 1965
  • Prasad AS, Diwany M, Gabr M, Sandstead HH, Mokhtar N, Hifney AE. Biochemical studies in thalassemia. Annals of Internal Medicine 1965;62:87-96.
Prasad 1966
  • Prasad AS. Metabolism of zinc and its deficiency in human subjects. Zinc Metabolism. Springfield: Charles C. Thomas, 1966:250-303.
Prasad 1983b
  • Prasad AS. Clinical, Biochemical And Nutritional Spectrum Of Zinc Deficiency In Human Subjects: An Update. Nutrition Reviews 1983;41(7):197-208.
Prasad 1985
Prasad 2007
  • Prasad AS . The Role of Zinc in Human Health. Academy of Turkish Sciences, 2007.
RDA 1989
  • Subcommittee on the Tenth Edition of the RDAs of the Food and Nutrition Board. Recommended Dietary Allowances. 10th Edition. Washington DC: National Academy Press, 1989.
RevMan 2011
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011.
Stewart 2007
  • Stewart KB, EmeryJ, Metcalfe S. Genetics in Family Medicine. 1st Edition. Australia: The Australian Government Agency Biotechnology, 2007.
Thomas 2006
Tracey 2005
  • Johnston TA. Haemoglobinopathies in pregnancy. The Obstetrician & Gynaecologist 2005;7(3):149-57.
WHO 1989
  • World Health Organization. Guidelines for the control of haemoglobin disorders. Report of the VIth Annual Meeting of the WHO working Group on Haemoglobinopathies,Cagliari, Sardinia 8-9 April 1989.
WHO 2006
  • WHO Secretariat. Thalassaemia and other haemoglobinopathies. http://apps.who.int/gb/ebwha/pdf_files/EB118/B118_5-en.pdf (accessed 11 February 2011).