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Levomepromazine for nausea and vomiting in palliative care

  1. Emily Darvill1,*,
  2. Saskie Dorman2,
  3. Paul Perkins3

Editorial Group: Cochrane Pain, Palliative and Supportive Care Group

Published Online: 30 APR 2013

Assessed as up-to-date: 27 MAR 2013

DOI: 10.1002/14651858.CD009420.pub2

How to Cite

Darvill E, Dorman S, Perkins P. Levomepromazine for nausea and vomiting in palliative care. Cochrane Database of Systematic Reviews 2013, Issue 4. Art. No.: CD009420. DOI: 10.1002/14651858.CD009420.pub2.

Author Information

  1. 1

    Cheltenham General Hospital, General Medicine, Cheltenham, UK

  2. 2

    Poole Hospital NHS Foundation Trust, Palliative Medicine, Poole, UK

  3. 3

    Sue Ryder Care Leckhampton Court Hospice, Cheltenham, Gloucestershire, UK

*Emily Darvill, General Medicine, Cheltenham General Hospital, Sandford Road, Cheltenham, GL53 7AN, UK.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 30 APR 2013


This is not the most recent version of the article. View current version (02 NOV 2015)


References to studies excluded from this review

  1. References to studies excluded from this review
  2. Additional references
Amesbury 2004 {published data only}
  • Amesbury B, Alloway L, Hickmore E, Dewhurst G. High-dose levomepromazine (methotrimeprazine) to control nausea in carcinoid syndrome. Journal of Palliative Care 2004;20(2):117-8.
Eisenchlas 2005 {published data only}
Ell 1983 {published data only}
  • Ell C, Konig H, Gutmann W. Prophylaxis of vomiting caused by cytostatic drugs - high dosage of metoclopramide versus antiemetic combination in controlled test [Prophylaxe von zytostatika-bedingtem Erbrechen. Hochdosiertes Metoclolpramid versus Antiemetika-Kombination im kontrollierten Vergleich]. Medizinische Welt 1983;34(35):945-8.
Higi 1980 {published data only}
  • Higi M, Niederle N, Schmidt C, Seeber S. Improved antiemetic treatment with levomepromazine [Verbesserte antiemetische Behandlung mit Levomepromazin bei zyotstatikabedingtem Erbrechen]. Deutsche Medizinische Wochenschrift 1980;105(22):794-5.
Kennett 2004 {published data only}
  • Kennet A, Hardy J, Shah S, A'Hern R. An open study of methotrimeprazine in the management of nausea and vomiting in patients with advanced cancer. Support Cancer Care 2004;13:715-21.
Martin 1988 {published data only}
  • Martin M, Diaz-Rubio E, Sanches Duran A, Almenarez J. Pilot study of levomepromazine in treatment of refractory postchemotherapy emesis [Estudio piloto de levomepromazina en el tratamiento de la emesis posquimioterapia refractaria]. Oncologia 1988;11(7):348-51.
McCabe 2003 {published data only}
  • McCabe H, Maraveyas A. Subcutaneous Levomepromazine Rescue (SLR) for high grade Delayed Chemotherapy-induced Emesis (DCIE). Anticancer Research 2003;23:5209-12.
Sgouros 2003 {unpublished data only}
  • Sgouros J, Neville-Webb H, Bunton S, Lind M, Maraveyas A. Levomepromazine versus dexamethasone with metoclopramide in the prevention of cisplatin induced delayed emesis. Preliminary results of a randomised study. British Journal of Cancer 2003;88:S68.

Additional references

  1. References to studies excluded from this review
  2. Additional references
Bentley 2001
Cochrane Handbook 2011
  • Higgins JPT, Altman DG, Sterne JAC (editors). Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from
Dahl 1977
  • Dahl SG, Strandjord RE, Sigfusson S. Pharmacokinetics and relative bioavailability of levomepromazine after repeated administration of tablets and syrup. European Journal of Clincal Pharmacology 1977;11:305-10.
Davis 2010
  • Davis MP, Hallerberg G, Palliative Medicine Study Group of the Multinational Association of Supportive Care in Cancer. A systematic review of the treatment of nausea and/or vomiting in cancer unrelated to chemotherapy or radiation. Journal of Pain and Symptom Management 2010;39(4):702-11.
Dietz 2013
  • Dietz I, Schmitz A, Lampey I, Schulz C. Evidence for the use of Levomepromazine for symptom control in the palliative care setting: a systematic review. BMC Palliative Care 2013;12:2.
Dorman 2010
Edmonds 2001
  • Edmonds P, Karlsen S, Khan S, Addington-Hall J. A comparison of the palliative care needs of patients dying from chronic respiratory diseases and lung cancer. Palliative Medicine 2001;15:287-95.
European Association for Palliative Care
  • European Association for Palliative Care. (accessed 26 January 2013).
Glare 2004
  • Glare P, Pereira G, Kristjanson L, Stockler M, Tattersall M. Systematic review of the efficacy of antiemetics in the treatment of nausea in patients with far-advanced cancer. Supportive Care in Cancer 2004;12:432-40.
Grande 2000
Hirst 2001
Jadad 1996
Keeley 2009
Klinkenberg 2004
Moore 2008
  • Moore RA, Barden J, Derry S, McQuay HJ. Managing potential publication bias. In: McQuay HJ, Kalso E, Moore RA editor(s). Systematic Reviews in Pain Research: Methodology Refined. Seattle: IASP Press, 2008:15-24.
Palliative Drugs 2008
  • Twycross R, Wilcock A (editors). Levomepromazine. Added June 2008 (accessed August 2011).
Perkins 2009
RevMan 2011
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011.
Skinner 1999
Twycross 1998
  • Twycross R, Back I. Nausea and vomiting in advanced cancer. European Journal of Palliative Care 1998;5:39-45.
Twycross 2011
  • Twycross R, Wilcock A. Palliative Care Formulary (PCF4). Ltd., 2011.
Wee 2008
  • Wee B, Hadley G, Derry S. How useful are systematic reviews for informing palliative care practice? Survey of 25 Cochrane systematic reviews. BMC Palliative Care 2008;7:13.