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Hypothermia for neuroprotection in children after cardiopulmonary arrest

  1. Barnaby Scholefield1,*,
  2. Heather Duncan1,
  3. Paul Davies2,
  4. Fang Gao Smith3,
  5. Khalid Khan4,
  6. Gavin D Perkins5,
  7. Kevin Morris1

Editorial Group: Cochrane Anaesthesia Group

Published Online: 28 FEB 2013

Assessed as up-to-date: 1 DEC 2011

DOI: 10.1002/14651858.CD009442.pub2

How to Cite

Scholefield B, Duncan H, Davies P, Gao Smith F, Khan K, Perkins GD, Morris K. Hypothermia for neuroprotection in children after cardiopulmonary arrest. Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD009442. DOI: 10.1002/14651858.CD009442.pub2.

Author Information

  1. 1

    Birmingham Children's Hospital, Paediatric Intensive Care Unit, Birmingham, UK

  2. 2

    Birmingham Children's Hospital, Department of Research and Development, Birmingham, UK

  3. 3

    University of Birmingham, Perioperative, Critical Care and Trauma Trials Group, School of Clinical and Experimental Medicine, Birmingham, UK

  4. 4

    Barts and the London School of Medicine, Queen Mary, University of London, Centre for Health Sciences, London, UK

  5. 5

    Warwick Medical School and Heart of England NHS Foundation Trust, Warwick, UK

*Barnaby Scholefield, Paediatric Intensive Care Unit, Birmingham Children's Hospital, Steelhouse Lane, Birmingham, B4 6NH, UK.

Publication History

  1. Publication Status: New
  2. Published Online: 28 FEB 2013



References to studies excluded from this review

  1. References to studies excluded from this review
  2. References to ongoing studies
  3. Additional references
Abend 2009 {published data only}
  • Abend NS, Topjian A, Ichord R, Herman ST, Helfaer M, Donnelly M, et al. Electroencephalographic monitoring during hypothermia after pediatric cardiac arrest. Neurology 2009;72(22):1931-40. [PUBMED: 19487651]
Bembea 2010 {published data only}
  • Bembea MM, Nadkarni VM, Diener-West M, Venugopal V, Carey SM, Berg RA, et al. Temperature patterns in the early postresuscitation period after pediatric inhospital cardiac arrest. Pediatric Critical Care Medicine 2010;11(6):723-30.
Buttram 2009 {published data only}
  • Buttram S, Large B, Yeakel K, Williams K, Bobrow B, Dalton H. Therapeutic hypothermia after pediatric out of hospital cardiac arrest - A single center experience. Critical Care Medicine 2009;37(12 Suppl):480.
Deasy 2010 {published data only}
  • Deasy C, Bernard SA, Cameron P, Jaison A, Smith K, Harriss L, et al. Epidemiology of paediatric out-of-hospital cardiac arrest in Melbourne, Australia. Resuscitation 2010;81(9):1095-100. [PUBMED: 20627518]
Doherty 2009 {published data only}
  • Doherty DR, Parshuram CS, Gaboury I, Hoskote A, Lacroix J, Tucci M, et al. Hypothermia therapy after pediatric cardiac arrest. Circulation 2009;119(11):1492-500. [PUBMED: 19273725]
Fink 2010 {published data only}
  • Fink EL, Clark RS, Kochanek PM, Bell MJ, Watson RS. A tertiary care center's experience with therapeutic hypothermia after pediatric cardiac arrest. PediatricCritical Care Medicine 2010;11(1):66-74. [PUBMED: 19935440]
Hein 2004 {published data only}
Kessler 2011 {published data only}
  • Kessler SK, Topjian AA, Gutierrez-Colina AM, Ichord RN, Donnelly M, Nadkarni VM, et al. Short-term outcome prediction by electroencephalographic features in children treated with therapeutic hypothermia after cardiac arrest. Neurocritical Care 2011;14(1):37-43. [PUBMED: 20890677]
Kobr 2011 {published data only}
  • Kobr J, Pizingerova K, Sasek L, Fremuth J, Fikrlova S. Induced therapeutic hypothermia following cardiac arrest in children. Bratislavske Lekarske Listy 2011;112(2):92-6. [PUBMED: 21456509]
Le Guen 2011 {published data only}
  • Le Guen M, Nicolas-Robin A, Carreira S, Raux M, Leprince P, Riou B, et al. Extracorporeal life support following out-of-hospital refractory cardiac arrest. Critical Care 2011;15(1):R29. [PUBMED: 21244674]
Meert 2009 {published data only}
  • Meert KL, Donaldson A, Nadkarni V, Tieves KS, Schleien CL, Brilli RJ, et al. Multicenter cohort study of in-hospital pediatric cardiac arrest. Pediatric Critical Care Medicine 2009;10(5):544-53; 613-5.
Meert 2010 {published data only}
Moler 2009 {published data only}
  • Moler FW, Meert K, Donaldson AE, Nadkarni V, Brilli RJ, Dalton HJ, et al. In-hospital versus out-of-hospital pediatric cardiac arrest: a multicenter cohort study. Critical Care Medicine 2009;37(7):2259-67.
Moler 2011 {published data only}
  • Moler FW, Donaldson AE, Meert K, Brilli RJ, Nadkarni V, Shaffner DH, et al. Multicenter cohort study of out-of-hospital pediatric cardiac arrest. Critical Care Medicine 2011;39(1):141-50.
Sanada 1998 {published data only}
  • Sanada T, Ueki M, Tokudome M, Okamura T, Nishiki S, Niimura A, et al. [Recovery from out-of-hospital cardiac arrest after mild hypothermia: report of two cases]. Masui. The Japanese Journal of Anesthesiology 1998;47(6):742-5. [PUBMED: 9691597]
Silfvast 2003 {published data only}
Takeda 2009 {published data only}
  • Takeda Y, Shiraishi K, Naito H, Morimoto N, Morita K. A randomized controlled trial of pharyngeal cooling system during cardiopulmonary resuscitation. Intensive Care Medicine 2009;35:143.
Topjian 2011 {published data only}
  • Topjian A, Hutchins L, DiLiberto MA, Abend NS, Ichord R, Helfaer M, et al. Induction and maintenance of therapeutic hypothermia after pediatric cardiac arrest: efficacy of a surface cooling protocol. Pediatric Critical Care Medicine 2011;12(3):e127-35. [PUBMED: 20431502]

References to ongoing studies

  1. References to studies excluded from this review
  2. References to ongoing studies
  3. Additional references
NCT00754481 {published data only}
  • NCT00754481. Hypothermia for Cardiac Arrest in Paediatrics (HypCAP). NCT00754481.
NCT00797680 {published data only}
  • NCT00797680. Duration of Hypothermia for Neuroprotection After Paediatric Cardiac Arrest. NCT00797680.
NCT00878644 {published data only}
  • NCT00878644. Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Paediatric Patients-(THAPCA-OH) (Out of Hospital) Trial. NCT00878644.
NCT00880087 {published data only}
  • NCT00880087. Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Paediatric Patients-(THAPCA-IH) (In Hospital) Trial. NCT00880087.

Additional references

  1. References to studies excluded from this review
  2. References to ongoing studies
  3. Additional references
Arrich 2012
Atkins 2009
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  • Azzopardi DV, Strohm B, Edwards AD, Dyet L, Halliday HL, Juszczak E, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. The New England Journal of Medicine 2009;361(14):1349-58. [PUBMED: 19797281]
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