Intervention Review

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Topical anti-inflammatory agents for seborrhoeic dermatitis of the face or scalp

  1. Helena Kastarinen1,*,
  2. Tuija Oksanen1,
  3. Enembe O Okokon2,
  4. Vesa V Kiviniemi3,
  5. Kristiina Airola4,
  6. Johanna Jyrkkä1,
  7. Tuomas Oravilahti1,
  8. Piia K Rannanheimo1,
  9. Jos H Verbeek5

Editorial Group: Cochrane Skin Group

Published Online: 19 MAY 2014

Assessed as up-to-date: 18 SEP 2013

DOI: 10.1002/14651858.CD009446.pub2


How to Cite

Kastarinen H, Oksanen T, Okokon EO, Kiviniemi VV, Airola K, Jyrkkä J, Oravilahti T, Rannanheimo PK, Verbeek JH. Topical anti-inflammatory agents for seborrhoeic dermatitis of the face or scalp. Cochrane Database of Systematic Reviews 2014, Issue 5. Art. No.: CD009446. DOI: 10.1002/14651858.CD009446.pub2.

Author Information

  1. 1

    Finnish Medicines Agency Fimea, Assessment of Pharmacotherapies, Fimea, Finland

  2. 2

    University of Calabar Teaching Hospital, Department of Community Medicine, Calabar, Cross River State, Nigeria

  3. 3

    Finnish Medicines Agency, Assessment of Pharmacotherapies, Kuopio, Finland

  4. 4

    Finnish Medicines Agency Fimea, Assessment of Medicinal Products, Fimea, Finland

  5. 5

    Finnish Institute of Occupational Health, Cochrane Occupational Safety and Health Review Group, Kuopio, Finland

*Helena Kastarinen, Assessment of Pharmacotherapies, Finnish Medicines Agency Fimea, P.O. Box 55, Fimea, 00034, Finland. helena.kastarinen@fimnet.fi.

Publication History

  1. Publication Status: New
  2. Published Online: 19 MAY 2014

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Attila 1992 {published data only}
  • Attila P, Förström L, Hannuksela M, Karvonen J, Lehtonen L, Salo OP. Clotrimazole-hydrocortisone, hydrocortisone and propylene glycol liniment in the treatment of seborrhoeic dermatitis of the scalp. Journal of Dermatological Treatment 1992;3(4):185-8. [EMBASE: 1993020255]
Basak 2001 {published data only}
Cicek 2009 {published data only}
  • Cicek D, Kandi B, Bakar S, Turgut D. Pimecrolimus 1% cream, methylprednisolone aceponate 0.1% cream and metronidazole 0.75% gel in the treatment of seborrhoeic dermatitis: a randomized clinical study. Journal of Dermatological Treatment 2009;20(6):344-9. [MEDLINE: 19954391]
Cornell 1986 {published data only}
  • Cornell RC. Atrophogenic potential of alclometasone dipropionate ointment 0.05% vs hydrocortisone ointment 1.0%. Current Therapeutic Research Clinical & Experimental 1986;39(2):260-8. [EMBASE: 1987091141]
Cornell 1989 {published data only}
  • Cornell RC, Ellis CN. Comparison of the efficacy and safety of amcinonide lotion 0.1% with those of betamethasone valerate lotion 0.1% in patients with seborrheic dermatitis. Current Therapeutic Research Clinical & Experimental 1989;46(3):577-86. [EMBASE: 1989232568]
Cornell 1993 {published data only}
  • Cornell RC, Baker MD. Dermal safety comparison of 0.05% desonide cream and 1.0% hydrocortisone cream. Current Therapeutic Research Clinical & Experimental 1993;53(4):356-9. [EMBASE: 1993234707]
Dreno 2002a {published data only}
  • Dreno B, Moyse D. Lithium gluconate in the treatment of seborrhoeic dermatitis: a multicenter, randomised, double-blind study versus placebo. European Journal of Dermatology 2002;12(6):549-52. [EMBASE: 2002448306]
  • Dreno B, Revuz J, Chosidow O, Bayrou O, Beylot C, Bonnetblanc JM, et al. Lithium gluconate 8% ointment in the treatment of moderate to severe seborrhoeic dermatitis. Journal of the European Academy of Dermatology & Venereology 2002;16(Suppl 1):153.
Dreno 2003 {published data only}
  • Dreno B, Chosidow O, Revuz J. Lithium vs ketoconazole in seborrheic dermatitis: a multicenter, randomized, controlled study. Annales of Dermatology & Venereology 2002;129(1):S696.
  • Dreno B, Chosidow O, Revuz J, Moyse D, Study Investigator Group. Lithium gluconate 8% vs. ketoconazole 2% in the treatment of seborrhoeic dermatitis: a multicentre, randomized study. British Journal of Dermatology 2003;148(6):1230-6. [MEDLINE: 12828753]
Elewski 2009a {published data only}
  • Elewski B. An investigator-blind, randomized, 4-week, parallel-group, multicenter pilot study to compare the safety and efficacy of a nonsteroidal cream (Promiseb Topical Cream) and desonide cream 0.05% in the twice-daily treatment of mild to moderate seborrheic dermatitis of the face. Clinics in Dermatology 2009;27(6 Suppl):S48-53. [MEDLINE: 19878781]
Faergemann 1986 {published data only}
Firooz 2006 {published data only}
  • Firooz A, Solhpour A, Gorouhi F, Daneshpazhooh M, Balighi K, Farsinejad K, et al. Pimecrolimus cream, 1%, vs hydrocortisone acetate cream, 1%, in the treatment of facial seborrheic dermatitis: a randomized, investigator-blind, clinical trial. Archives of Dermatology 2006;142(8):1066-7. [MEDLINE: 16924062]
Fredriksson 1978 {published data only}
  • Fredriksson T. A comparison between hydrocortisone 17-butyrate and betamethasone 17α-valerate in seborrhoeic dermatitis of the scalp. IRCS Medical Science: Clinical Medicine; Clinical Pharmacology and Therapeutics; Connective Tissue, Skin and Bone 1978;6(2):70. [EMBASE: 0979014893]
General Practitioner 1982 {published data only}
  • General Practitioner Research Group. Topical corticosteroids in seborrhoeic dermatitis. A report from the general practitioner research group. Practitioner 1982;226(1368):1178-9. [EMBASE: 1982217563]
Gip 1979 {published data only}
  • Gip L. A study to compare the efficacy of hydrocortisone 17-butyrate (Locoid) 0.1% scalp lotion and betamethasone 17-valerage (Betnovate) 0.1% lotion in the treatment of seborrhoeic dermatitis of the scalp. Current Therapeutic Research Clinical & Experimental 1979;26(5):607-10. [EMBASE: 1980112442]
Harris 1972 {published data only}
  • Harris JJ. A national double-blind clinical trial of a new corticosteroid lotion: a 12-investigator cooperative analysis. Current therapeutic research, clinical & experimental 1972;14(9):638-46. [EMBASE: 4263888]
Hersle 1996 {published data only}
  • Hersle K, Mobacken H, Nordin P. Mometasone furoate solution 0.1% compared with ketoconazole shampoo 2% for seborrheic dermatitis of the scalp. Current Therapeutic Research Clinical & Experimental 1996;57(7):516-22. [EMBASE: 1996233065]
Katsambas 1989 {published data only}
Koc 2009 {published data only}
  • Koc E, Arca E, Kose O, Akar A. An open, randomized, prospective, comparative study of topical pimecrolimus 1% cream and topical ketoconazole 2% cream in the treatment of seborrheic dermatitis. Journal of Dermatological Treatment 2009;20(1):4-9. [EMBASE: 2009111157]
Kousidou 1992 {published data only}
  • Kousidou T, Panagiotidou D, Boutli F, Mourellou O, Ioannidis D, Fotidou D, et al. A double-blind comparison of 2% ketoconazole cream and 1% hydrocortisone cream in the treatment of seborrheic dermatitis. Current Therapeutic Research, Clinical & Experimental 1992;51(5):723-9. [EMBASE: 1992159176]
Langtry 1997 {published data only}
Ludvigsen 1983 {published data only}
  • Ludvigsen K. Treatment of seborrhoeic dermatitis of the scalp. Report of a double-blind comparative trial of hydrocortisone 17-butyrate 0.1% lotion (Locoid) and betamethasone 17,21-Dipropionate 0.05% Lotion (Diproderm). Clinical Trials Journal 1983;20(6):313-8. [EMBASE: 1984018112]
Lynfield 1988 {published data only}
  • Lynfield Y, Cornell RC, Horwitz SN, Huntley AC, Millikan LE. Amcinonide lotion 0.1% in the treatment of patients with seborrheic dermatitis of the scalp and/or other hairy areas. Current Therapeutic Research Clinical & Experimental 1988;44(2):304-14. [EMBASE: 1989002094]
Medansky 1992 {published data only}
  • Medansky RS, Lepaw MI, Shavin JS, Zimmerman EH, Jones ML, Peets EA, et al. Mometasone furoate cream 0.1% vs. hydrocortisone cream 1% in the treatment of seborrhoeic dermatitis. Journal of Dermatological Treatment 1992;3(3):125-8. [EMBASE: 1992296411]
Ortonne 1992 {published data only}
  • Ortonne J-P, Lacour J-P, Vitetta A, Le Fichoux Y. Comparative Study of Ketoconazole 2% Foaming Gel and Betamethasone Dipropionate 0,05% Lotion in the Treatment of Seborrhoeic Dermatitis in Adults. Dermatology 1992;184(4):275-80. [EMBASE: 1992177939]
Ortonne 2011 {published data only}
  • Ortonne JP, Nikkels AF, Reich K, Ponce Olivera RM, Lee JH, Kerrouche N, et al. Efficacious and safe management of moderate to severe scalp seborrhoeic dermatitis using clobetasol propionate shampoo 0.05% combined with ketoconazole shampoo 2%: a randomized, controlled study. British Journal of Dermatology 2011;165(1):171-6. [EMBASE: 2011355146]
Papp 2012 {published data only}
  • Papp KA, Papp A, Dahmer B, Clark CS. Single-blind, randomized controlled trial evaluating the treatment of facial seborrheic dermatitis with hydrocortisone 1% ointment compared with tacrolimus 0.1% ointment in adults. Journal of the American Academy of Dermatology 2012;67(1):e11-5. [EMBASE: 2012342025]
Pari 1998 {published data only}
  • Pari T, Pulimood S, Jacob M, George S, Jeyaseelan L, Thomas K. Randomized double blind controlled trial 2% ketoconazole cream versus 0,05% clobetasol 17-butyrate cream in seborrhoeic dermatitis. Journal of the European Academy of Dermatology & Venereology 1998; Vol. 10, issue 1:89-90. [EMBASE: 1998052808]
Piepponen 1992 {published data only}
  • Piepponen T, Suhonen R, Rantanen T, Blomqvist K, Pajarre R, Lehtonen L. Treatment of dandruff with a ketoconazole 2% shampoo. Journal of Dermatological Treatment 1992;3(3):119-23. [EMBASE: 1992296410]
Ramirez 1993 {published data only}
  • Ramirez RG, Dorton D. Double-blind placebo-controlled multicentre study of fluocinolone acetonide shampoo (FS Shampoo) in scalp seborrhoeic dermatitis. Journal of Dermatological Treatment 1993;4(3):135-7. [EMBASE: 1993311639]
Reygagne 2007 {published data only}
  • Reygagne P, Poncet M, Sidou F, Soto P. Clobetasol propionate shampoo 0.05% in the treatment of seborrheic dermatitis of the scalp: results of a pilot study. Cutis 2007;79(5):397-403. [EMBASE: 17569404]
Rigopoulos 2004 {published data only}
  • Rigopoulos D, Ioannides D, Kalogeromitros D, Gregoriou S, Katsambas A. Pimecrolimus cream 1% vs. betamethasone 17-valerate 0.1% cream in the treatment of seborrhoeic dermatitis. A randomized open-label clinical trial. British Journal of Dermatology 2004;151(5):1071-5. [EMBASE: 2004512755]
Rudner 1970 {published data only}
  • Rudner EJ, Samovitz M. Seborrheic Dermatitis of the Face - Treated with Fluocinolone Acetonide Solution: A Double Blind Study. Cutis 1970;6:320-2.
Shin 2009 {published data only}
Stratigos 1988 {published data only}
  • Stratigos J, Antoniou C, Katsambas A, Böhler K, Fritsch P, Schmölz A, et al. Ketoconazole 2% cream versus hydrocortisone 1% cream in the treatment of seborrheic dermatitis. A double-blind comparative study. Journal of the American Academy of Dermatology 1988;19(5 Pt 1):850-3. [MEDLINE: 2973476]
Van't Veen 1998 {published data only}
  • Van't Veen AJ, Prevoo RLMA, Velders AJ, Jagtman BA, van Niel JCG, Stolz E. Betamethasone-17-valerate compared with ketoconazole for topical treatment of seborrhoeic dermatitis of the scalp in adults. Results of a Dutch multicenter study. Journal of Dermatological Treatment 1998;9(4):239-45. [EMBASE: 1999025626]
Warshaw 2007 {published data only}
  • Warshaw EM, Wohlhuter RJ, Liu A, Zeller SA, Wenner RA, Bowers S, et al. Results of a randomized, double-blind, vehicle-controlled efficacy trial of pimecrolimus cream 1% for the treatment of moderate to severe facial seborrheic dermatitis. Journal of the American Academy of Dermatology 2007;57(2):257-64. [MEDLINE: 17188780]

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Aertgeerts 1985 {published data only}
  • Aertgeerts P, Albring M, Klaschka F, Nasemann T, Patzelt-Wenczler R, Rauhut K, et al. Comparative testing of Kamillosan cream and steroidal (0.25% hydrocortisone, 0.75% fluocortin butyl ester) and non-steroidal (5% bufexamac) dermatologic agents in maintenance therapy of eczematous diseases [Vergleichende Prufung von Kamillosan Creme gegenuber steroidalen (0,25% Hydrocortison, 0,75% Fluocortinbutylester) und nichtsteroidalen (5% Bufexamac) Externa in der Erhaltungstherapie von Ekzemerkrankungen]. Zeitschrift für Hautkrankheiten 1985;60(3):270-7. [EMBASE: 3158124]
Albrecht 1986 {published data only}
  • Albrecht G. Berlin Multicenter Study on Prednicarbate Preparations in Dermatologic Practices [Das Berliner Modell. Multicenterstudie mit Prednicarbat in verschiedenen Vehikeln]. Zeitschrift für Hautkrankheiten 1986;61(Suppl 1):88-96. [MEDLINE: 2939636]
Alebiosu 2003 {published data only}
  • Alebiosu CO, Ogunledun A, Ogunleye DS. A report of clinical trial conducted on Toto ointment and soap products. Journal of the National Medical Association 2003;95(1):95-105. [MEDLINE: 12656456]
Alexander 1967 {published data only}
Amos 1994 {published data only}
  • Amos HE, MacLennan AI, Boorman GC. Clinical efficacy of Polytar AF (Fongitar) and Nizoral scalp treatments in patients with dandruff/seborrhoeic dermatitis. Journal of Dermatological Treatment 1994;5(3):127-30. [EMBASE: 1994316061]
Anonymous 1994a {published data only}
  • Anonymous. Management of seborrhoic dermatitis [Therapie der seborrhoischen Dermatitis]. Der Hautarzt 1994;45(4 Suppl):1-4. [EMBASE: 9218049]
Anonymous 1994b {published data only}
  • Anonymous. Seborrheic dermatitis: Lithium deprives the growth basis of yeast fungus [Seborrhoische Dermatitis: Lithium entzieht Hefepilz die Wachstumsgrundlage]. Therapiewoche 1994;44(18):1032-3. [EMBASE: 1994176542]
Arenas 1999 {published data only}
  • Arenas R, Monroy E, Farrera RF, Abiega CD. Double blind and aleatory study to evaluate efficacy of icthiol/octopirox/salicilic acid in seborrehic dermatitis [Estudio doble ciego, al azar, para evaluar la eficacia de ictiol/octopirox/acido salicilico en dermatitis seborreica de la piel cabelluda]. Dermatologia Revista Mexicana 1999;43(4):157-63. [EMBASE: 1999365285]
Attarzadeh 2013 {published data only}
  • Attarzadeh Y, Asilian A, Shahmoradi Z, Adibi N. Comparing the efficacy of emu oil with clotrimazole and hydrocortisone in the treatment of seborrheic dermatitis: a clinical trial. Journal of Research in Medical Sciences 2013;18(6):477-81. [MEDLINE: 24250695]
Banerjee 1975 {published data only}
  • Banerjee BN, Mandal SB, Dutta AK. Evaluation of furacin-s (nitrofurazone and hydrocortisone acetate) in the treatment of different dermatoses. Indian Journal of Dermatology, Venerology & Leprology 1975;41(6):209-14. [EMBASE: 0977052085]
Barbanoj 2005 {published data only}
  • Barbanoj MJ, Antonijoan R, Garcia-Gea C, Puntes M, Gich I, Jane F. Eberconazole cream: topical and general tolerability, sensitisation potential, and systemic availability. Methods & Findings in Experimental & Clinical Pharmacology 2005;27(4):227-34. [EMBASE: 2005220616]
Basak 1999 {published data only}
  • Başak PY, Ergin Ş. Comparative effects of calcipotriol and betamethasone 17-valerate in seborrhoeic dermatitis of the scalp [Abstract P-547]. The 8th Congress of the European Academy of Dermatology and Venereology. Amsterdam, The Netherlands 29thSept-3rd October 1999. Journal of European Adacemy of Dermatology and Venereology 1999;12(Suppl 2):S295.
Bertamino 1975 {published data only}
  • Bertamino R. A new topical corticosteroid. Its evaluation in a double-blind trial [Un nuovo Corticosteroide per uso topico. Sua valutazione in condizioni di doppia cecità]. Riforma Medica 1975;89(15):706-13. [EMBASE: 0976142422]
Binder 1972 {published data only}
  • Binder R, McCleary J. Comparison of fluocinonide in a double-blind study with betamethasone valerate. Current Therapeutic Research 1972;14(1):35-8. [EMBASE: 4257862]
Boyle 1986 {published data only}
Camarasa 1975 {published data only}
  • Camarasa G. Clinical testing of a new local corticoid: desoxymethasone [Klinische Erprobung eines neuen lokalen Kortikoids: Desoximetason]. Zeitschrift für Hautkrankheiten 1975;50(Suppl 2):21-4. [EMBASE: 132780]
Carboni 1982 {published data only}
  • Carboni G, Longhi-Gelati M, Pierfelice V. Clinical observations on two new liquid forms of clobetasol propionate in seborrhoeic eczema [Osservazioni cliniche su due nuove forme liquide di clobetasolo propionato sull'eczema seborroico]. Giornale Italiano di Dermatologia e Venereologia 1982;117(1):V-X. [EMBASE: 1982225929]
Christodoulou 1983 {published data only}
  • Christodoulou GN, Georgala S, Vareltzides A, Catsarou A. Lithium in seborrheic dermatitis. Psychiatric Journal of the University of Ottawa 1983;8(1):27-9. [EMBASE: 1983187066]
Cuelenaere 1992 {published data only}
Curley 1990 {published data only}
  • Curley RK, Vickers CF, Norris T, Glover DR. A comparative study of betamethasone dipropionate with salicylic acid and betamethasone valerate for the treatment of steroid-responsive dermatoses of the scalp. Journal of Dermatological Treatment 1990;1(4):203-6. [EMBASE: 1990343409]
Davies 1999 {published data only}
  • Davies DB, Boorman GC, Shuttleworth D. Comparative efficacy of shampoos containing coal tar (4.0% w/W;TarmedTM), coal tar (4.0% w/w) plus ciclopirox olamine (1.0% w/w; TarmedTM AF) and ketoconazole (2.0% w/w; Nizoral®) for the treatment of dandruff/seborrhoeic dermatitis. Journal of Dermatological Treatment 1999;10(3):177-83. [EMBASE: 1999324981]
de la Brassine 1984 {published data only}
  • de la Brassine M, Kint A, Lachapelle JM, Tennstedt D. Halomethasone (C 48.401-Ba) for the Topical Treatment of Common Dermatoses. Journal of International Medical Research 1984;12(5):307-9. [EMBASE: 1984244422]
Dobrev 2003 {published data only}
  • Dobrev H, Zissova L, Yankova R. Study of four antidandruff shampoos therapeutic effectiveness [Abstract P25-7]. The 12th Congress of the European Academy of Dermatology and Venereology Barcelona, Spain 15-18th October 2003. Journal of the European Academy of Dermatology & Venereology 2003;17(Suppl 3):342.
Elewski 2009b {published data only}
Elie 1983 {published data only}
  • Elie R, Durocher LP, Kavalec EC. Effect of salicylic acid on the activity of betamethasone-17,21-dipropionate in the treatment of erythematous squamous dermatoses. Journal of International Medical Research 1983;11(2):108-12. [EMBASE: 1983129354]
Eun 2009 {published data only}
  • Eun HC. Clinical efficacies of topical agents for the treatment of seborrheic dermatitis on the scalp. 67th Annual Meeting of the American Academy of Dermatology, AAD San Francisco, CA United States. Conference Start: 20090306 Conference End: 20090310. Journal of the American Academy of Dermatology 2009;60(3 Suppl 1):AB47. [EMBASE: 70141908]
Franz 2000 {published data only}
Fredriksson 1975a {published data only}
  • Fredriksson T, Gip L, Hamfelt A. Investigations of a new synthetic steroid, betamethasone-17, 21-dipropionate, in alcoholic solution. Current Therapeutic Research, Clinical & Experimental 1975;18(2):324-31. [EMBASE: 0976132342]
Fredriksson 1985 {published data only}
  • Fredriksson T. Controlled comparison of Clinitar Shampoo and Selsun Shampoo in the treatment of seborrhoeic dermatitis of the scalp. British Journal of Clinical Practice 1985;39(1):25-8. [EMBASE: 1985059997]
Freeman 2002 {published data only}
  • Freeman S, Howard A, Foley P, Rosen R, Wood G, See J-A, et al. Efficacy, cutaneous tolerance and cosmetic acceptability of desonide 0.05% lotion (Desowen®) versus vehicle in the short-term treatment of facial atopic or seborrhoeic dermatitis. Australasian Journal of Dermatology 2002;43(3):186-9. [EMBASE: 2002259552]
Fritz 1995 {published data only}
  • Fritz K, Itschert G. Topical application of 8% Lithiumsuccinat and 0.05% Zincsulfate in seborrhoic Dermatitis. [Lokaltherapie des seborrhoischen Ekzems mit 0.05% Zinksulfat und 8% Lithiumsuccinat]. H + G Zeitschrift Fur Hautkrankheiten 1995;70:155-6.
Futterer 1981 {published data only}
  • Futterer E. Evaluation of efficacy of antidandruff agents. Journal of the Society of Cosmetic Chemists of Japan 1981;32(6):327-38. [EMBASE: 1982133716]
Gayko 2006 {published data only}
  • Gayko G, Warnecke J, Zelenkova H. The use of a pale type of Ichthyol in cosmetic dermatology. Cosmetic, single-centre, controlled and randomized double blind study for proof of efficacy and tolerance of a combination of Ichthyol Pale 0.5% and ketoconazole 0.5% vs. ketoconazole 1.0% shampoo in treatment of moderate to severe dandruff. Dermatologia Kliniczna 2006;8(4):243-7. [EMBASE: 2007006167]
Gentry 1973 {published data only}
Goffin 1996 {published data only}
  • Goffin V, Pierard-Franchimont C, Pierard GE. Antidandruff shampoos and the stratum corneum. Journal of Dermatological Treatment 1996;7(4):215-8. [EMBASE: 1997028593]
Gould 1988 {published data only}
  • Gould DJ, Davies MG, Kersey PJW, Kenicer K, Green C, Strong A, et al. Topical lithium succinate - a safe and effective treatment for seborrhoeic dermatitis in adults. International Pharmaceutical Abstracts British Journal of Dermatology 1988;119:27-8.
Grossman 1997 {published data only}
  • Grossman R, Gisoldi E, Phillips S, Cauwenbergh G. A comparative efficacy study of two dandruff shampoos [Abstract 1206]. The 19th World Congress of Dermatology 15-20 June, 1997 Sydney, Australia. Australasian Journal of Dermatology 1997;38(Suppl 2):94.
High 2006 {published data only}
  • High WA, Pandya AG. Pilot trial of 1% pimecrolimus cream in the treatment of seborrheic dermatitis in African American adults with associated hypopigmentation. Journal of the American Academy of Dermatology 2006;54(6):1083-8. [EMBASE: 2006227424]
Hochman 1988 {published data only}
  • Hochman HA, Schwartz SR. A comparison of two sulfur and salicylic acid shampoos in the treatment of dandruff. Current Therapeutic Research Clinical & Experimental 1988;44(6):1071-5. [EMBASE: 1989023984]
Humke 2002 {published data only}
  • Humke S, Budde MA, Richard A, Rougier A, Krutmann J. Efficacy and tolerability of a new shampoo in the treatment of dandruff [Abstract PO425]. 20th World Congress of Dermatology Paris 1st to 5th July 2002. Annales de Dermatologie et de Venereologie 2002;129:1S454.
Jacksonville 1969 {published data only}
  • Jacksonville Dermatology Society. Hydrocortisone Alcohol in the Treatment of Seborrheic Dermatitis. Cutis 1969;5(9):1130-2.
Jafferany 2008 {published data only}
  • Jafferany M. Lithium and skin: dermatologic manifestations of lithium therapy. International Journal of Dermatology 2008; Vol. 47, issue 11:1101-11. [EMBASE: 2008520868]
Jaramillo 1992 {published data only}
  • Jaramillo Antillón O, Hernández López J, Koon Rodríguez S, Rodríguez Vindas J, Freer Bustamante E. Comparative double-blind, randomized zinc pyrithion 1.5 shampoo in the treatment of dandruff [Estudio comparativo a doble ciego y aleatoria del zinc pyrithion al 1.5% en champu en el tratamiento de la caspa]. Revista Costarricense de Ciencias Medicas 1992;13(1/2):33-6.
Jensen 2009 {published data only}
  • Jensen J, Clausen C, Folster-Holst R, Proksch E, Poblete-Gutierrez P. Seborrheic eczema responds more quickly to treatment with pimecrolimus cream than treatment with ketoconazole cream. 36th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung, ADF Heidelberg Germany. Conference Start: 20090305 Conference End: 20090307. Experimental Dermatology 2009;18(3):302. [EMBASE: 70202963]
Jensen 2010 {published data only}
  • Jensen J-M, Clausen C, Brasch J, Brautigam M, Glaser R, Schwarz T, et al. Pimecrolimus Cream Treatment Normalizes Clinical Symptoms, Skin Barrier Function and Antimicrobial Protein Expression in Seborrheic Eczema. 40th Annual Meeting of the European Society for Dermatological Research Helsinki Finland. Conference Start: 20100908 Conference End: 20100911. Journal of Investigative Dermatology 2010;130(Issue S2):S69. [EMBASE: 70263800]
Kaminester 2002 {published data only}
  • Kaminester L, Bhagwat D. Clinical efficacy of a unique 10% sulfacetamide lotion in patients with seborrheic dermatitis of the scalp [Abstract P1982]. 20th World Congress of Dermatology Paris 1st to 5th July 2002. Annales de Dermatologie et de Venereologie 2002;129:1S758.
Karsono 2010 {published data only}
  • Karsono JK, Kerr K, Darcy T, Henry J, Mizoguchi H, Schwartz J, et al. New innovations in anti-dandruff technology: Proteomics application [Abstract]. 1st Eastern Asia Dermatology Congress, EADC2010 Fukuoka Japan. Conference Start: 20100930 Conference End: 20101003. Journal of Dermatology 2010;37:97. [EMBASE: 70284716]
Kim 2012 {published data only}
  • Kim TW, Jwa SW, Song M, Kim HS, Ko HC, Kim MB, et al. How frequently should 0.1% tacrolimus ointment be used to reduce exacerbation of stabilised adult facial seborrhoeic dermatitis? Results from a randomised, double-blind, vehicle-controlled, multi-centre trial [Abstract]. 2nd Eastern Asia Dermatology Congress Beijing China. Conference Start: 20120613 Conference End: 20120615. Journal of Dermatology 2012;39(Suppl):19. [EMBASE: 70800535]
Kim 2013 {published data only}
  • Kim TW, Mun JH, Jwa SW, Song M, Kim HS, Ko HC, et al. Proactive treatment of adult facial seborrhoeic dermatitis with 0.1% tacrolimus ointment: randomized, double-blind, vehicle-controlled, multi-centre trial. Acta Dermato-Venereologica 2013;93(5):557-561. [EMBASE: 2013558915]
Kircik 2009 {published data only}
  • Kircik L. An open-label, single-center pilot study to determine the antifungal activity of a new nonsteroidal cream (Promiseb Topical Cream) after 7 days of use in healthy volunteers. Clinics in Dermatology 2009;27(6 Suppl):S44-7. [EMBASE: 19878780]
Levy 1974 {published data only}
  • Levy J, Highly FM Jr. Double-Blind Trial of a New Topical Corticosteroid in a US Naval Hospital. Military Medicine 1974;139(9):728-30. [EMBASE: 0975135470]
Li 2000 {published data only}
  • Li FC, Liu F, Wang XL. Observations to the curative effects in the treatment of 120 cases of seborrhoeic dermatitis and pityriasis capitis with triatop and coal tar lotion. Journal of Clinical Dermatology 2000;29:290.
Lin 2010 {published data only}
López Padilla 1996 {published data only}
  • López Padilla S, Carvajal A. Ketoconazole 1% shampoo vs climbazole shampoo on the treatment of seborrhoeic dermatitis in scalp skin [Ketoconazol al 1 por ciento champú vs. climbazole champú en el tratamiento de la dermatitis seborreica en piel cabelluda]. Dermatología Revista Mexina 1996;40(3):190-5.
Luo 1993 {published data only}
  • Luo QL, Shun GX, Wu XG, Li S, Tang Z. The clinical observation of 901 cases multi-effective lotion for scalp steatorrhea dermatitis (Chinese). Chinese Journal of Dermatovenereology 1993;7(2):98-9.
Marks 1974 {published data only}
  • Marks R, Bhogal B, Wilson L. The effect of betamethasone valerate on seborrhoeic dermatitis of the scalp. A clinical, histopathological and cell kinetic study. Acta Dermato-Venereologica 1974;54(5):373-5. [EMBASE: 0975122569]
Mensing 2008 {published data only}
  • Mensing CO, Mensing CH, Mensing H. Treatment with pimecrolimus cream 1% clears irritant dermatitis of the periocular region, face and neck. International Journal of Dermatology 2008; Vol. 47, issue 9:960-4. [EMBASE: 2008402864]
Nolting 1983 {published data only}
  • Nolting S, Hagemeier HH. Betamethasone-17,21-dipropionate plus salicylic acid compared with betamethasone-dipropionate solution in the therapy of erythemato-squamous dermatoses [Therapie erythrosquamoser Dermatosen. Betamethason-Dipropionat plus Salizylsaure im Vergleich zu Betamethason-Dipropionat-Losung]. Fortschritte der Medizin 1983;101(37):1679-83. [EMBASE: 6227542]
Nolting 1985 {published data only}
  • Nolting S. Treatment with topical corticosteroids in severe or resistant dermatoses [Behandlung mit Kortikosteroid-Externa bei schweren oder resistenten Dermatosen]. Dermatosen in Beruf und Umwelt 1985;33(4):140-4. [EMBASE: 1985211204]
Pierard-Franchimont 1995 {published data only}
  • Pierard-Franchimont C, Pierard P. Subjects using anti-dandruff shampoos. Journal of the European Academy of Dermatology & Venereology 1995;5(Suppl 1):S153.
Pierard-Franchimont 1999 {published data only}
  • Pierard-Franchimont C, Henry F, Uhoda I, Pierard GE. Comparative anti-dandruff efficacy between a tar and a non-tar shampoo. Journal of the European Academy of Dermatology & Venereology 1999;12:S305.
Pierard-Franchimont 2000 {published data only}
Pierard-Franchimont 2002a {published data only}
  • Pierard-Franchimont C, Goffin V, Henry F, Uhoda I, Braham C, Pierard GE. Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations. International Journal of Cosmetic Science 2002;24(5):249-56. [EMBASE: 2002427181]
Pierard-Franchimont 2002b {published data only}
  • Pierard-Franchimont C, Pierard GE. A double-blind placebo-controlled study of ketoconazole + desonide gel combination in the treatment of facial seborrheic dermatitis. Dermatology 2002;204(4):344-7. [EMBASE: 2002222909]
Pierard-Franchimont 2002c {published data only}
  • Pierard-Franchimont C, Goffin V, Decroix J, Pierard GE. A multicenter randomized trial of ketoconazole 2% and zinc pyrithione 1% shampoos in severe dandruff and seborrheic dermatitis. Skin Pharmacology & Applied Skin Physiology 2002;15(6):434-41. [EMBASE: 2003001937]
Reiffenstuhl 1973 {published data only}
  • Reiffenstuhl B, Wolf D. Clinical experiences with fluocinonide FAPG [Klinische Erfahrungen mit Fluocinonid FAPG]. Wiener Medizinische Wochenschrift 1973;123(38):555-6. [EMBASE: 4270843]
Reinhard 1974 {published data only}
  • Reinhard W, Weber G, Petres J. Comparative studies with halcinonide and fluocortolone in local administration [Vergleichende Untersuchungen mit Halcinonid und Fluocortolon bei lokaler Applikation]. Zeitschrift für Hautkrankheiten 1974;49(7):267-72. [EMBASE: 4275779]
Sohn 1978 {published data only}
  • Sohn HS, Kim YP. A Study on the Effectiveness of Clocortolone Pivalate (Purantix®) Cream on Certain Common Skin diseases. Korean Journal of Dermatology 1978;16(4):311-7. [EMBASE: 0979011221]
Tomoka 1973 {published data only}
  • Tomoka MT, Ochoa AG. Clinical effectiveness of fluocinonide in several skin diseases [Klinische Wirksamkeit des Fluocinonid bei verschiedenen Dermatosen]. Wiener medizinische Wochenschrift 1973;123(15):247-8. [EMBASE: 4267190]
Turnbull 1982 {published data only}
  • Turnbull BC. Locoid vs Betnovate lotion in the treatment of seborrhoeic and atopic dermatitis of the scalp. New Zealand Medical Journal 1982;95(718):738-40. [EMBASE: 1983057047]
Veien 1980 {published data only}
Wacker 1989 {published data only}
  • Wacker KH. Treatment of seborrhoeic dermatitis and other disorders of the scalp requiring corticosteroids using alclometasone dipropionate 0.05% solution. Results of a double-blind-study [DELONAL LOSUNG (ALCLOMETASONDIPROPIONAT 0,05%) BEI SEBORRHOISCHEM KOPFEKZEM UND ANDEREN KORTIKOIDBEDURFTIGEN KOPFHAUTERKRAMKUNGEN. ERGEBNISSE EINER DOPPELBLINDSTUDIE]. Aktuelle Dermatologie 1989;15(3):84-7. [EMBASE: 1989080414]
Weiss 2011 {published data only}
  • Weiss S, Raton B, Wyres M, Brundage T. A novel foam vehicle is consistently preferred by patients for dermatologic conditions [Abstract]. 69th Annual Meeting of the American Academy of Dermatology New Orleans, LA United States. Conference Start: 20110204 Conference End: 20110208. Journal of the American Academy of Dermatology 2011;64(2 Suppl 1):AB50. [EMBASE: 70331516]
Wollina 2006 {published data only}
Wollina 2007 {published data only}
  • Wollina U. The role of topical calcineurin inhibitors for skin diseases other than atopic dermatitis. American Journal of Clinical Dermatology 2007;8(3):157-73. [EMBASE: 2007314620]
Yawalkar 1983 {published data only}
  • Yawalkar SJ, Macarol V, Montanari C. An Overview of International Clinical Trials with Halometasone Cream. Journal of International Medical Research 1983;11(Suppl 1):1-7. [EMBASE: 1983071917]

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Fredriksson 1975b {published data only}
  • Fredriksson T. Treatment of seborrheic dermatitis: double-blind studies comparing dexamethasone 0.012% and fluocinolone acetonide 0.01%. Cutis 1975;15(5):765-8. [EMBASE: 0976065942]
Snyder 1969 {published data only}
  • Snyder BL. A double blind evaluation of fluocinolone acetonide solution in the treatment of seborrheic dermatitis of the face. Pennsylvania Medicine 1969;72(6):68-9. [EMBASE: 4239005]

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
EudraCT 2005-006208-21 {published data only}
  • 2005-006208-21. Clinical Efficacy of Pimecrolimus Cream in Seborrheic Dermatitis. Efficacy of pimecrolimus in normalizing clinical symptoms, explorative study of barrier function, hydration, lipid content and differentiation in seborrheic dermatitis: a randomized, double-blind study in adults with seborrheic dermatitis treated with 1 % pimecrolimus cream versus 2 % ketoconazole cream as control. www.clinicaltrialsregister.eu/ctr-search/search?query=eudract_number:2005-006208-21 (accessed 28 May 2013).
EudraCT 2006-003984-30 {published data only}
  • 2006-003984-30. A multicenter, randomized, double-blind, two-arm, vehicle-controlled, parallel-group, two stage study to evaluate and demonstrate the efficacy and to evaluate the safety of pimecrolimus 1% cream in the treatment of seborrhoeic dermatitis in patients 12 years of age and older. www.clinicaltrialsregister.eu/ctr-search/search?query=eudract_number:2006-003984-30 (accessed 28 May 2013).
EudraCT 2007-007088-25 {published data only}
  • 2007-007088-25. Inflammatory seborrhoeic dermatitis of the scalp in adult. www.clinicaltrialsregister.eu/ctr-search/search?query=2007-007088-25 (accessed 28 May 2013).
EudraCT 2009-013120-23 {published data only}
  • 2009-013120-23. Efficacy and safety of LBC 45 (lithium gluconate) for the treatment of seborrhoeic dermatitis of the scalp [Efficacité et tolérance du LBC 45 dans la dermite séborrhéique du cuir chevelu]. www.clinicaltrialsregister.eu/ctr-search/search?query=2009-013120-23 (accessed 28 May 2013).
EudraCT 2010-022861-93 {published data only}
  • 2010-022861-93. Confirmation of th efficacy and safety of LBC 45 (lithium gluconate) for the treatment of seborrhoeic dermatitis of the scalp [Confirmation de l'efficacité et de la tolérance du LBC 45 dans la dermite séborrhéique du cuir chevelu]. www.clinicaltrialsregister.eu/ctr-search/search?query=2010-022861-93 (accessed 28 May 2013).
NCT00403559 {published data only}
  • NCT00403559. A 4 Week Study of Elidel for the Treatment of Seborrheic Dermatitis. clinicaltrials.gov/ct2/show/NCT00403559 (accessed 28 May 2013).
NCT01011621 {published data only}
  • NCT01011621. Efficacy and Tolerability of Prednisolone Acetate 0.5% Cream Versus Betamethasone Valerate 0.1% Cream in Cortisosensitive Dermatosis. clinicaltrials.gov/ct2/show/study/NCT01011621 (accessed 28 May 2013).

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Ang-Tiu 2012
  • Ang-Tiu C, Maghrajani C, Maano C. Pimecrolimus 1% cream for the treatment of seborrheic dermatitis: a systematic review of randomized controlled trials.. Expert Review of Clinical Pharmacology 2012;5(1):91-7. [EMBASE: 2011676752]
Burton 1983
Del Rosso 2011
  • Del Rosso JQ. Adult Seborrheic Dermatitis: A Status Report on Practical Topical Management. The Journal of Clinical and Aesthetic Dermatology 2011;4(5):32-8. [PUBMED: 21607192 ]
Foley 2003
  • Foley P, Zuo Y, Plunkett A, Merlin K, Marks R. The frequency of common skin conditions in pre-school-aged children in Australia: seborrheic dermatitis and pityriasis capitis (cradle cap). Archives of Dermatology 2003;139(3):318-22. [MEDLINE: 12622623]
Gupta 2004
Halder 2003
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. Available from www.cochrane-handbook.org.
Kim 2010
  • Kim D, Lockey R. Dermatology for the allergist. World Allergy Organization Journal 2010;3(6):202-15. [MEDLINE: 23268431]
Naldi 2009
Okokon 2011
Schwartz 2006