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Naproxen with or without an antiemetic for acute migraine headaches in adults

  1. Simon Law1,
  2. Sheena Derry2,*,
  3. R Andrew Moore2

Editorial Group: Cochrane Pain, Palliative and Supportive Care Group

Published Online: 20 OCT 2013

Assessed as up-to-date: 22 MAY 2013

DOI: 10.1002/14651858.CD009455.pub2


How to Cite

Law S, Derry S, Moore RA. Naproxen with or without an antiemetic for acute migraine headaches in adults. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD009455. DOI: 10.1002/14651858.CD009455.pub2.

Author Information

  1. 1

    Gloucester Hospitals NHS Foundation Trust, Department of Anaesthetics, Gloucestershire, UK

  2. 2

    University of Oxford, Pain Research and Nuffield Department of Clinical Neurosciences, Oxford, Oxfordshire, UK

*Sheena Derry, Pain Research and Nuffield Department of Clinical Neurosciences, University of Oxford, Pain Research Unit, Churchill Hospital, Oxford, Oxfordshire, OX3 7LE, UK. sheena.derry@ndcn.ox.ac.uk.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 20 OCT 2013

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[Figure 1]
Figure 1. Study flow diagram.
[Figure 2]
Figure 2. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 3]
Figure 3. Forest plot of comparison: 1 Pain, outcome: 1.1 Pain-free response at two hours.
[Figure 4]
Figure 4. L'Abbé plot for pain-free response at two hours. Size of circle proportional to size of study (see inset scale). Cream = naproxen 500 mg, blue = naproxen 825 mg.
[Figure 5]
Figure 5. Forest plot of comparison: 1 Pain, outcome: 1.4 Headache relief at two hours.
[Figure 6]
Figure 6. L'Abbé plot for headache relief at two hours. Size of circle proportional to size of study (see inset scale). Cream = naproxen 500 mg, blue = naproxen 825 mg.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Naproxen versus placebo, Outcome 1 Pain-free response at 2 h.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Naproxen versus placebo, Outcome 2 Headache relief at 2 h.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Naproxen versus placebo, Outcome 3 24-h sustained pain-free.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Naproxen versus placebo, Outcome 4 24-h sustained headache relief.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Naproxen versus placebo, Outcome 5 Any adverse event.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Naproxen versus placebo, Outcome 6 Use of rescue medication.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Naproxen versus placebo, Outcome 7 Relief of associated symptoms.
[Analysis 1.8]
Analysis 1.8. Comparison 1 Naproxen versus placebo, Outcome 8 Relief of functional disability.