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Adenosine and verapamil for no-reflow during primary percutaneous coronary intervention in people with acute myocardial infarction

  1. Kyaw Aung Naing1,
  2. Lang Li1,*,
  3. Qiang Su1,
  4. Taixiang Wu2

Editorial Group: Cochrane Heart Group

Published Online: 4 JUN 2013

Assessed as up-to-date: 29 FEB 2012

DOI: 10.1002/14651858.CD009503.pub2


How to Cite

Aung Naing K, Li L, Su Q, Wu T. Adenosine and verapamil for no-reflow during primary percutaneous coronary intervention in people with acute myocardial infarction. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD009503. DOI: 10.1002/14651858.CD009503.pub2.

Author Information

  1. 1

    The First Affiliated Hospital of Guangxi Medical University, Department of Cardiology, Nanning, Guangxi, China

  2. 2

    West China Hospital, Sichuan University, Chinese Clinical Trial Registry, Chinese Ethics Committee of Registering Clinical Trials, Chengdu, Sichuan, China

*Lang Li, Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, No 6, Shuang Yong Load, Nanning, Guangxi, 530021, China. drlilang@163.com.

Publication History

  1. Publication Status: New
  2. Published Online: 4 JUN 2013

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This is not the most recent version of the article. View current version (18 MAY 2015)

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Desmet 2011 {published data only}
  • Desmet W, Bogaert J, Dubois C, Sinnaeve P, Adriaenssens T, Pappas C, et al. High-dose intracoronary adenosine for myocardial salvage in patients with acute ST-segment elevation myocardial infarction. European Heart Journal 2011;32(7):867-77. [PUBMED: 21196444]
Fokkema 2009 {published data only}
  • Fokkema ML, Vlaar PJ, Vogelzang M, Gu YL, Kampinga MA, De Smet BJ, et al. Effect of high-dose intracoronary adenosine administration during primary percutaneous coronary intervention in acute myocardial infarction: a randomized controlled trial. Circulation. Cardiovascular Interventions 2009;2(4):323-9. [PUBMED: 20031735]
Grygier 2011 {published data only}
  • Grygier M, Araszkiewicz A, Lesiak M, Janus M, Kowal J, Skorupski W, et al. New method of intracoronary adenosine injection to prevent microvascular reperfusion injury in patients with acute myocardial infarction undergoing percutaneous coronary intervention. The American Journal of Cardiology 2011;107(8):1131-5. [PUBMED: 21310372]
Ji 2007 {published data only}
  • Ji ZG, Han JM, Liu G, Liu K. Effect of adenosine on ischemia-reperfusion injury during percutaneous coronary intervention. Journal of Clinical Rehabilitative Tissue Engineering Research 2007; Vol. 11, issue 51:10399-403.
Marzilli 2000 {published data only}
  • Marzilli M, Orsini E, Marraccini P, Testa R. Beneficial effects of intracoronary adenosine as an adjunct to primary angioplasty in acute myocardial infarction. Circulation 2000;101(18):2154-9. [PUBMED: 10801755]
Micari 2005 {published data only}
  • Micari A, Belcik TA, Balcells EA, Powers E, Wei K, Kaul S, et al. Improvement in microvascular reflow and reduction of infarct size with adenosine in patients undergoing primary coronary stenting. The American Journal of Cardiology 2005;96(10):1410-5. [PUBMED: 16275189]
Petronio 2005 {published data only}
  • Petronio AS, De Carlo M, Ciabatti N, Amoroso G, Limbruno U, Palagi C, et al. Left ventricular remodeling after primary coronary angioplasty in patients treated with abciximab or intracoronary adenosine. American Heart Journal 2005;150(5):1015. [PUBMED: 16290987]
Stoel 2008 {published data only}
Taniyama 1997 {published data only}
  • Taniyama Y, Ito H, Iwakura K, Masuyama T, Hori M, Takiuchi S, et al. Beneficial effect of intracoronary verapamil on microvascular and myocardial salvage in patients with acute myocardial infarction. Journal of the American College of Cardiology 1997;30(5):1193-9. [PUBMED: 9350914]
Wang 2008 {published data only}
  • Wang Xin, Ding Zhi Jian, Chen Jie Zhong. 在急诊经皮冠状动脉介入治疗中腺苷的应用研究. Journal of Clinical Medicine In Practice 2008; Vol. 12, issue 5.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Babbitt 1988 {published data only}
  • Babbitt D G, Perry J M, Forman M B. Intracoronary verapamil for reversal of refractory coronary vasospasm during percutaneous transluminal coronary angioplasty. Journal of the American College of Cardiology 1988;12:1377-81.
Dani 2009 {published data only}
  • Dani S, Prajapati J, Jain S, Joshi H, Thanvi S, Sharma K, et al. Comparative data of intracoronary nicorandil and intracoronary adenosine in no (slow) reflow after primary percutaneous transluminal coronary angioplasty. American Journal of Cardiology 2009;103 (9):4B.
De Luca 2012 {published data only}
  • De Luca G, Iorio S, Venegoni L, Marino P. Evaluation of intracoronary adenosine to prevent periprocedural myonecrosis in elective percutaneous coronary intervention (from the PREVENT-ICARUS trial). American Journal of Cardiology 2012;109:202-7.
Dillon 2001 {published data only}
Fischell 1998 {published data only}
Forman 2008 {published data only}
  • Forman M B, Hou D M, Jackson E K. Treating acute "no-reflow" with intracoronary adenosine in 4 patients during percutaneous coronary intervention. Texas Heart Institute Journal 2008;35:439-46.
Garratt 1998 {published data only}
  • Garratt KN, Holmes DR Jr, Molina-Viamonte V, Reeder GS, Hodge DO, Bailey KR, et al. Intravenous adenosine and lidocaine in patients with acute mycocardial infarction. American Heart Journal 1998; Vol. 136, issue 2:196-204.
Granger 1997 {published data only}
Hang 2005 {published data only}
  • Hang CL, Wang CP, Yip HK, Yang CH, Guo GB, Wu CJ, et al. Early administration of intracoronary verapamil improves myocardial perfusion during percutaneous coronary interventions for acute myocardial infarction. Chest 2005;128(4):2593-8.
Harding 2006 {published data only}
Heidland 2000 {published data only}
  • Heidland UE, Heintzen MP, Michel CJ, Strauer BE. Effect of adjunctive intracoronary adenosine on myocardial ischemia, hemodynamic function and left ventricular performance during percutaneous transluminal coronary angioplasty: clinical access to ischemic preconditioning?. Coronary Artery Disease 2000, issue 5:421-8.
Ibrahim 2002 {published data only}
  • Ibrahim D, Huseyin Y, Cengiz E, Oktay S. Treatment of no-reflow phenomenon with verapamil after primary stent deployment during myocardial infarction. Japanese Heart Journal 2002;43:573-80.
Kelly 2005 {published data only}
Kim 2009 {published data only}
  • Kim SJ, Kim W, Park SH, Kim JT, Hwang SH, Gang DG, et al. Effect on myocardial protection of intracoronary adenosine and nicorandil injection in patients undergoing nonurgent percutaneous coronary intervention. American Journal of Cardiology 2009;103(9):18B.
Kloner 2006 {published data only}
  • Kloner RA, Forman MB, Gibbons RJ, Ross AM, Alexander RW, Stone GW. Impact of time to therapy and reperfusion modality on the efficacy of adenosine in acute myocardial infarction: the AMISTAD-2 trial. European Heart Journal 2006;27(20):2400-5.
Kopecky 2003 {published data only}
  • Kopecky SL, Aviles RJ, Bell MR, Lobl JK, Tipping D, Frommell G, et al. A randomized, double-blinded, placebo-controlled, dose-ranging study measuring the effect of an adenosine agonist on infarct size reduction in patients undergoing primary percutaneous,transluminal under coronary angioplasty: The ADMIRE (AmP579 Delivery for Myocardial Infarction REduction) study. American Heart Journal 2003;146(1):146-52.
Lee 2007 {published data only}
  • Lee CH, Low A, Tai BC, Co M, Chan MY, Lim J, et al. Pretreatment with intracoronary adenosine reduces the incidence of myonecrosis after non-urgent percutaneous coronary intervention - A prospective randomized study. European Heart Journal 2007; Vol. 28, issue 1:19-25.
Lim 2004 {published data only}
  • Lim SY, Bae EH, Jeong MH, Kang DG, Lim YS, Kim KH, et al. Effect of combined intracoronary adenosine and nicorandil on no-reflow phenomenon during percutaneous coronary intervention. Circulation Journal 2004;68(10):928-32.
Masaya 2004 {published data only}
  • Masaya K, Keigo D, Shota S, Hiroaki T, Seiji H, Daiji H. Intracoronary verapamil rapidly terminates reperfusion tachyarrhythmias in acute myocardial infarction. Chest 2004;126(3):702-8.
Matsuo 2007 {published data only}
  • Matsuo H, Watanabe S, Watanabe T, Warita S, Kojima T, Hirose T, et al. Prevention of no-reflow/slow-flow phenomenon during rotational atherectomy - A prospective randomized study comparing intracoronary continuous infusion of verapamil and nicorandil. American Heart Journal 2007; Vol. 154, issue 5:994. e1-6.
Michaels 2002 {published data only}
  • Michaels AD, Appleby M, Otten MH, Dauterman K, Ports TA, Chou TM, et al. Pretreatment with intragraft verapamil prior to percutaneous coronary intervention of saphenous vein graft lesions: results of the randomized, controlled vasodilator prevention on no-reflow (VAPOR) trial. Journal of Invasive Cardiology 2002;14(6):299-302.
Parikh 2004 {published data only}
  • Parikh K, Shah HD, Chag M, Shah U, Baxi H, Chandarana A, et al. Improvement in MACE by sequential administration of boluses or intracoronary adenosine and sodium nitroprusside during percutaneous coronary interventions. European Heart Journal 2004;25:518-9.
Parikh 2007 {published data only}
  • Parikh KH, Chag MC, Shah KJ, Shah UG, Baxi HA, Chandarana AH, et al. Intracoronary boluses of adenosine and sodium nitroprusside in combination reverses slow/no-reflow during angioplasty: a clinical scenario of ischemic preconditioning. Canadian Journal of Physiology and Pharmacology 2007;85:476-82.
Rezkalla 2010 {published data only}
Ross 2005 {published data only}
  • Ross AM, Gibbons RJ, Stone GW, Kloner RA, Alexander RW, Investigators Amistad-II. A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD-II). Journal of the American College of Cardiology 2005;45(11):1775-80.
Sakuma 2010 {published data only}
  • Tadamichi S, Chikaaki M, Takehito T, Toshiharu O, Hiromichi T, Takenori O, et al. Exogenous adenosine triphosphate disodium administration during primary percutaneous coronary intervention reduces no-reflow and preserves left ventricular function in patients with acute anterior myocardial infarction: a study using myocardial contrast echocardiography. International Journal of Cardiology 2010;140(2):200-9.
Tian 2008 {published data only}
  • Tian F, Chen YD, Lü SZ, Song XT, Yuan F, Fang F, et al. Intracoronary adenosine improves myocardial perfusion in late reperfused myocardial infarction. Chinese Medical Journal 2008;121(3):195-9.
Tsao 2009 {published data only}
  • Tsao TP, Cheng SM, Cheng CC, Yang SP. Comparison of intracoronary adenosine and isosorbide dinitrate on no-reflow/slow flow during rotational atherectomy. Acta Cardiologica 2009;64(2):225-30.
Vijayalakshmi 2006 {published data only}
  • Vijayalakshmi K, Whittaker VJ, Kunadian B, Graham J, Wright RA, Hall JA, et al. Prospective, randomised, controlled trial to study the effect of intracoronary injection of verapamil and adenosine on coronary blood flow during percutaneous coronary intervention in patients with acute coronary syndromes. Heart (British Cardiac Society) 2006;92(9):1278-84. [PUBMED: 16449518]
Werner 2002 {published data only}
  • Werner GS, Lang K, Kuehnert H, Figulla HR. Intracoronary verapamil for reversal of no-reflow during coronary angioplasty for acute myocardial infarction. Catheterization and Cardiovascular Interventions 2002; Vol. 57, issue 4:444-51.
Wilkinson 2010 {published data only}
  • Wilkinson JR, Wragg A, Kapur A, Dymond DS. A single centre experience of pharmacological pre-treatment of saphenous vein grafts to prevent no reflow post intervention. EuroIntervention Conference: EuroPCR. 2010.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Huang 2009 {published data only}
  • Huang D, Ma J, Zhang F, Wang X, Ge L, Qian J, et al. Effects of different vasodilators on no-reflow phenomenon during percutaneous coronary intervention in patients with acute myocardial infarction. European Heart Journal 2009;30:248-9.
Jing 2010 {published data only}
  • Jing W, Yun-Dai C, Xiao Z, Guang Z. Adenosine improves myocardial perfusion in patients treated with percutaneous coronary intervention for first acute myocardial infarction. Circulation 2010;122 (2):e162.
Micari 2004 {published data only}
  • Micari A, Belcik T, Balcells E, Kaul S, Wei K, Powers ER, et al. Intravenous adenosine improves microvascular reflow assessed by contrast echocardiography in patients with acute myocardial infarction. Circulation 2004;110:718.
Zhen-Guo 2010 {published data only}
  • Zhen-Guo J, Jian-Miao H, Gang L. Myocardial protective effect of adenosine during percutaneous coronary intervention. Circulation 2010;122 (2):e247.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Garcia-Dorado 2008 {published data only}
  • Myocardial protection during reperfusion in patients with acute coronary syndrome with ST segment elevation submitted to primary angioplasty: Effect of intracoronary adenosine on infarct size and ventricular remodeling.. Ongoing study October 2008.
Gershlick 2011 {published data only}
  • Randomized controlled trial comparing intracoronary administration of adenosine or sodium nitroprusside to control for attenuation of microvascular obstruction during primary percutaneous coronary intervention. Ongoing study 27/04/2011.
Niccoli 2009b {published data only}
  • Niccoli G, D'amario D, Spaziani C, Cosentino N, Marino M, Rigattieri S, et al. Randomized evaluation of intracoronary nitroprusside vs. adenosine after thrombus aspiration during primary percutaneous coronary intervention for the prevention of no-reflow in acute myocardial infarction: the REOPEN-AMI study protocol. Journal of Cardiovascular Medicine 2009;10(7):585-92. [PUBMED: 19384242]

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Akhtar 1989
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Berne 1980
Boersma 2006
  • Boersma E. Does time matter? A pooled analysis of randomized clinical trials comparing primary percutaneous coronary intervention and in-hospital fibrinolysis in acute myocardial infarction patients. European Heart Journal 2006;27(7):779-88. [PUBMED: 16513663]
Boissel 1999
  • Boissel JP, Cucherat M, Li W, Chatellier G, Gueyffier F, Buyse M, et al. The problem of therapeutic efficacy indices. 3. Comparison of the indices and their use. Therapie 1999;54(4):405-11.
Cochrane Handbook
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Eeckhout 2001
Egger 1997
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Forman 2006
Henriques 2003
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Higgins 2003
Huikuri 2001
Ikeda 1981
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Keeley 2003
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Kunadian 2008
  • Kunadian V, Zorkun C, Williams SP, Biller LH, Palmer AM, Ogando KJ, et al. Intracoronary pharmacotherapy in the management of coronary microvascular dysfunction. Journal of Thrombosis and Thrombolysis 2008;26(3):234-42. [PUBMED: 18818881]
Lefebvre 2011
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Minamino 1998
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Morishima 1995
  • Morishima I, Sone T, Mokuno S, Taga S, Shimauchi A, Oki Y, et al. Clinical significance of no-reflow phenomenon observed on angiography after successful treatment of acute myocardial infarction with percutaneous transluminal coronary angioplasty. American Heart Journal 1995;130(2):239-43. [PUBMED: 7631601]
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Rezkalla 2008
Simes 1995
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Thygesen 2007
Van de Werf 2008
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Weaver 1997
  • Weaver WD, Simes RJ, Betriu A, Grines CL, Zijlstra F, Garcia E, et al. Comparison of primary coronary angioplasty and intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review. JAMA 1997;278(23):2093-8. [PUBMED: 9403425]
White 2008
Zijlstra 1993
  • Zijlstra F, De Boer MJ, Hoorntje JC, Reiffers S, Reiber JH, Suryapranata H. A comparison of immediate coronary angioplasty with intravenous streptokinase in acute myocardial infarction. New England Journal of Medicine 1993;328(10):680-4. [PUBMED: 8433726]