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Isoflavones for hypercholesterolaemia in adults

  1. Yu Qin1,
  2. Kai Niu2,
  3. Yuan Zeng1,
  4. Peng Liu1,
  5. Long Yi1,
  6. Ting Zhang1,
  7. Qian Yong Zhang1,
  8. Jun Dong Zhu1,
  9. Man Tian Mi1,*

Editorial Group: Cochrane Metabolic and Endocrine Disorders Group

Published Online: 6 JUN 2013

Assessed as up-to-date: 30 SEP 2012

DOI: 10.1002/14651858.CD009518.pub2

How to Cite

Qin Y, Niu K, Zeng Y, Liu P, Yi L, Zhang T, Zhang QY, Zhu JD, Mi MT. Isoflavones for hypercholesterolaemia in adults. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD009518. DOI: 10.1002/14651858.CD009518.pub2.

Author Information

  1. 1

    Third Military Medical University, Nutrition, Chongqing, Chongqing, China

  2. 2

    Third Military medical University, Cancer, Xinqiao Hospital, Chongqing, China

*Man Tian Mi, Nutrition, Third Military Medical University, No 30, Gaotanyan Street, Chongqing, Chongqing, 400038, China.

Publication History

  1. Publication Status: New
  2. Published Online: 6 JUN 2013



References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Aubertin-Leheudre 2008 {published data only}
  • Aubertin-Leheudre M, Lord C, Khalil A, Dionne IJ. Effect of 6 months of exercise and isoflavone supplementation on clinical cardiovascular risk factors in obese postmenopausal women: a randomized, double-blind study. Menopause 2007;14(4):624-9. [MEDLINE: 17290158]
  • Aubertin-Leheudre M, Lord C, Khalil A, Dionne IJ. Isoflavones and clinical cardiovascular risk factors in obese postmenopausal women: a randomized double-blind placebo-controlled trial. Journal of Womens Health 2008;17:1363-9.
Dewell 2002 {published data only}
  • Dewell A, Hollenbeck CB, Bruce B. The effects of soy-derived phytoestrogens on serum lipids and lipoproteins in moderately hypercholesterolemic postmenopausal women. Journal of Clinical Endocrinology and Metabolism 2002;87(1):118-21. [MEDLINE: 11788633]
Gardner 2001 {published data only}
  • Gardner CD, Newell KA, Cherin R, Haskell WL. The effect of soy protein with or without isoflavones relative to milk protein on plasma lipids in hypercholesterolemic postmenopausal women. American Journal of Clinical Nutrition 2001;73(4):728-35. [MEDLINE: 11273847]
Mackey 2000 {published data only}
Wang 2005 {published data only}
  • Wang YS, Zhang GR, Liu YJ, Zhuo HX, Xia FL. Effects of isoflavones on blood lipid profiles in perimenopausal women [大豆异黄酮对女性围绝经期血脂代谢的影响]. Zhong Hua Xian Dai Zhong Xi Yi Za Zhi 2005;3(19):1738-9.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Atkinson 2004 {published data only}
  • Atkinson C, Oosthuizen W, Scollen S, Loktionov A, Day NE, Bingham SA. Modest protective effects of isoflavones from a red clover-derived dietary supplement on cardiovascular disease risk factors in perimenopausal women, and evidence of an interaction with ApoE genotype in 49-65 year-old women. Journal of Nutrition 2004;134(7):1759-64. [MEDLINE: 15226466]
Badeau 2007 {published data only}
  • Badeau R, Jauhiainen M, Metso J, Nikander E, Tikkanen MJ, Ylikorkala O, et al. Effect of isolated isoflavone supplementation on ABCA1-dependent cholesterol efflux potential in postmenopausal women. Menopause 2007;14(2):293-9. [MEDLINE: 17224860]
Blakesmith 2003 {published data only}
  • Blakesmith SJ, Lyons-Wall PM, George C, Joannou GE, Petocz P, Samman S. Effects of supplementation with purified red clover (Trifolium pratense) isoflavones on plasma lipids and insulin resistance in healthy premenopausal women. British Journal of Nutrition 2003;89(4):467-74. [MEDLINE: 12654164]
Cancellieri 2007 {published data only}
  • Cancellieri F, De Leo V, Genazzani AD, Nappi C, Parenti GL, Polatti F, et al. Efficacy on menopausal neurovegetative symptoms and some plasma lipids blood levels of an herbal product containing isoflavones and other plant extracts. Maturitas 2007;56(3):249-56. [MEDLINE: 17275225]
Chedraui 2008 {published data only}
  • Chedraui P, San Miguel G, Hidalgo L, Morocho N, Ross S. Effect of Trifolium pratense-derived isoflavones on the lipid profile of postmenopausal women with increased body mass index. Gynecological Endocrinology 2008;24(11):620-4. [MEDLINE: 19031218]
Cheng 2007 {published data only}
Cianci 2012 {published data only}
  • Cianci A, Cicero AF, Colacurci N, Matarazzo MG, De Leo V. Activity of isoflavones and berberine on vasomotor symptoms and lipid profile in menopausal women. Gynecological Endocrinology 2012;28:699-702. [MEDLINE: 22313171]
Colacurci 2005 {published data only}
  • Colacurci N, Chiàntera A, Fornaro F, de Novellis V, Manzella D, Arciello A. Effects of soy isoflavones on endothelial function in healthy postmenopausal women. Menopause 2005;12(3):299-307. [MEDLINE: 15879919]
Dent 2001 {published data only}
  • Dent SB, Peterson CT, Brace LD, Swain JH, Reddy MB, Hanson KB, et al. Soy protein intake by perimenopausal women does not affect circulating lipids and lipoproteins or coagulation and fibrinolytic factors. Journal of Nutrition 2001;131(9):2280-7. [MEDLINE: 11533267]
Fornaro 2006 {published data only}
  • Fornaro F, Carotenuto V, Bisogni C, Trabucco E, Russo C, Manzella D, et al. Brachial reactivity in postmenopausal women: Impact of soy isoflavone administration. Italian Journal of Gynaecology and Obstetrics 2006;18:106-10. [EMBASE: 44822700]
Gallagher 2004 {published data only}
Garrido 2006 {published data only}
Gonzalez 2007 {published data only}
Han 2002 {published data only}
Hidalgo 2005 {published data only}
  • Hidalgo LA, Chedraui PA, Morocho N, Ross S, San Miguel G. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Gynecological Endocrinology 2005;21(5):257-64. [MEDLINE: 16373244]
Ho 2007 {published data only}
  • Ho SC, Chen YM, Ho SS, Woo JL. Soy isoflavone supplementation and fasting serum glucose and lipid profile among postmenopausal Chinese women: a double-blind, randomized, placebo-controlled trial. Menopause 2007;14(5):905-12. [MEDLINE: 17413839]
Jiang 2008 {published data only}
  • Jiang M, Xu YF, Miao ZL, Zhong XM, Zhang M, Liu N. Effects of isoflavones on blood lipid profiles in perimenopausal women [大豆异黄酮对围绝经期妇女血脂水平的影响]. ZhongGuo Shi Yong Yi Yao 2008;3(17):49-50.
Lee 2012 {published data only}
  • Lee M, Chae S, Cha Y, Park Y. Supplementation of Korean fermented soy paste doenjang reduces visceral fat in overweight subjects with mutant uncoupling protein-1 allele. Nutrition Research 2012;32:8-14. [MEDLINE: 22260858]
Liang 2007 {published data only}
  • Liang SP, Zhang DP. Observation and analysis of the lipid-lowering effects of oat soy flour [燕麦大豆粉降脂作用的观察与分析]. ZhongGuo Wu Zhen Xue Za Zhi 2007;7(3):466.
Llaneza 2010 {published data only}
  • Llaneza P, Gonzalez C, Fernandez-Iñarrea J, Alonso A, Diaz-Fernandez MJ, Arnott I, et al. Soy isoflavones, Mediterranean diet, and physical exercise in postmenopausal women with insulin resistance. Menopause 2010;17(2):372-8. [EMBASE: 2010168638; MEDLINE: 20216276]
Marini 2010 {published data only}
  • Marini H, Bitto A, Altavilla D, Burnett BP, Polito F, Di Stefano V, et al. Efficacy of genistein aglycone on some cardiovascular risk factors and homocysteine levels: a follow-up study. Nutrition Metabolism and Cardiovascular Diseases 2010;20(5):332-40. [MEDLINE: 19631515]
Nikander 2004 {published data only}
  • Nikander E, Tiitinen A, Laitinen K, Tikkanen M, Ylikorkala O. Effects of isolated isoflavonoids on lipids, lipoproteins, insulin sensitivity, and ghrelin in postmenopausal women. Journal of Clinical Endocrinology and Metabolism 2004;89(7):3567-72. [MEDLINE: 15240647]
Oliveira 2012 {published data only}
  • Oliveira LP, de Jesus RP, Boulhosa RS, Mendes CM, Gnoatto MC, Lemaire DC, et al. Effect of soy protein supplementation in patients with chronic hepatitis C: a randomized clinical trial. World Journal of Gastroenterology 2012;18(18):2203-11. [MEDLINE: 22611313]
Ozturk 2009 {published data only}
  • OzturkTurhan N, Iltemir Duvan C, Bolkan F, Onaran Y. Effect of isoflavone on plasma nitrite/nitrate, homocysteine, and lipid levels in Turkish women in the early postmenopausal period: a randomized controlled trial. Turkish Journal of Medical Sciences 2009;39:367-75. [EMBASE: 354824750]
Petri Nahas 2004 {published data only}
  • Petri Nahas E, Nahás Neto J, De Luca L, Traiman P, Pontes A, Dalben I. Benefits of soy germ isoflavones in postmenopausal women with contraindication for conventional hormone replacement therapy. Maturitas 2004;48(4):372-80. [MEDLINE: 15283929]
Rios 2008 {published data only}
  • Rios DR, Rodrigues ET, Cardoso AP, Montes MB, Franceschini SA, Toloi MR. Lack of effects of isoflavones on the lipid profile of Brazilian postmenopausal women. Nutrition 2008;24(11-12):1153-8. [MEDLINE: 18842392]
Schult 2004 {published data only}
Swain 2002 {published data only}
  • Swain JH, Alekel DL, Dent SB, Peterson CT, Ready MB. Iron indexes and total antioxidant status in response to soy protein intake in perimenopausal women. American Journal of Clinical Nutrition 2002;76:165-71. [EMBASE: 34686562]
Terzic 2009 {published data only}
Törmälä 2006 {published data only}
  • Törmälä RM, Nikander E, Tiitinen A, Väisänen-Tommiska M, Ylikorkala O, Mikkola TS. Serum cholesterol efflux potential in postmenopausal women treated with isolated isoflavones. Menopause 2006;13(1):96-101. [MEDLINE: 16607104]
Uesugi 2003 {published data only}
  • Uesugi T, Toda T, Okuhira T, Chen JT. Evidence of estrogenic effect by the three-month-intervention of isoflavone on vaginal maturation and bone metabolism in early postmenopausal women. Endocrine Journal 2003;50:613-9. [MEDLINE: 14614218]
Villa 2009 {published data only}
  • Villa P, Costantini B, Suriano R, Perri C, Macrì F, Ricciardi L, et al. The differential effect of the phytoestrogen genistein on cardiovascular risk factors in postmenopausal women: relationship with the metabolic status. Journal of Clinical Endocrinology and Metabolism 2009;94(2):552-8. [MEDLINE: 19017760]
Wong 2012 {published data only}
  • Wong JM, Kendall CW, Marchie A, Liu Z, Vidgen E, Holmes C, et al. Equol status and blood lipid profile in hyperlipidemia after consumption of diets containing soy foods. American Journal of Clinical Nutrition 2012;95(3):564-71. [MEDLINE: 22301925]
Woo 2003 {published data only}
  • Woo J, Lau E, Ho SC, Cheng F, Chan C, Chan AS, et al. Comparison of Pueraria lobata with hormone replacement therapy in treating the adverse health consequences of menopause. Menopause 2003;10(4):352-61. [MEDLINE: 12851519]
Wu 2006a {published data only}
Wu 2006b {published data only}
  • Wu J, Oka J, Higuchi M, Tabata I, Toda T, Fujioka M, et al. Cooperative effects of isoflavones and exercise on bone and lipid metabolism in postmenopausal Japanese women: a randomized placebo-controlled trial. Metabolism: Clinical and Experimental 2006;55(4):423-33. [MEDLINE: 16546471]
Xiao 2003 {published data only}
  • Xiao LZ, Jiang ZP, Xu X, Huang Z, Lai SY, Hu BH. Effects of isoflavones on blood lipid profiles and endothelial function in postmenopausal women [大豆异黄酮对绝经后X综合征患者血脂及内皮功能的影响]. Lin Chung Xin Xue Guan Bing Za Zhi 2003;19(5):302-3.
Ye 2012 {published data only}
  • Ye YB, Wang ZL, Zhuo SY, Lu W, Liao HF, Verbruggen M, et al. Soy germ isoflavones improve menopausal symptoms but have no effect on blood lipids in early postmenopausal Chinese women: a randomized placebo-controlled trial. Menopause 2012;19:791-8. [MEDLINE: 22278344]
Yildiz 2005 {published data only}
  • Yildiz MF, Kumru S, Godekmerdan A, Kutlu S. Effects of raloxifene, hormone therapy, and soy isoflavone on serum high-sensitive C-reactive protein in postmenopausal women. International Journal of Gynaecology and Obstetrics 2005;90(2):128-33. [MEDLINE: 15970291]

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Albertazzi 2005
Badimon 2011
Chun 2007
Duncan 2000
  • Duncan AM, Merz-Demlow BE, Xu X, Phipps WR, Kurzer MS. Premenopausal equol excretors show plasma hormone profiles associated with lowered risk of breast cancer. Cancer Epidemiology, Biomarkers and Prevention 2000;9(6):581-6. [PUBMED: 10868692]
Farzadfar 2011
  • Farzadfar F, Finucane MM, Danaei G, Pelizzari PM, Cowan MJ, Paciorek, et al. National, regional, and global trends in serum total cholesterol since 1980: systematic analysis of health examination surveys and epidemiological studies with 321 country-years and 3.0 million participants. Lancet 2011;377(9765):578-86. [PUBMED: 21295847]
Ford 2007
  • Ford ES, Ajani UA, Croft JB, Critchley JA, Labarthe DR, Kottke TE, et al. Explaining the decrease in U.S. deaths from coronary disease, 1980-2000. New England Journal of Medicine 2007;356(23):2388-98. [PUBMED: 17554120]
He 2004
  • He J, Gu D, Reynolds K, Wu X, Muntner P, Zhao J, et al. Serum total and lipoprotein cholesterol levels and awareness, treatment, and control of hypercholesterolemia in China. Circulation 2004;110(4):405-11. [PUBMED: 15238453]
Higgins 2002
Higgins 2003
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from
Jackson 2011
Kang 2010
  • Kang X, Zhang Q, Wang S, Huang X, Jin S. Effect of soy isoflavones on breast cancer recurrence and death for patients receiving adjuvant endocrine therapy. Canadian Medical Association Journal 2010;182(17):1857-62. [PUBMED: 20956506]
Keinan 2002
  • Keinan-Boker L, Peeters PH, Mulligan AA, Navarro C, Slimani N, Mattisson I, et al. Soy product consumption in 10 European countries: the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Public Health Nutrition 2002;5(6B):1217-26. [PUBMED: 12639228]
Kreijkamp 2005
  • Kreijkamp-Kaspers S, Kok L, Bots ML, Grobbee DE, Lampe JW, Van der Schouw YT. Randomized controlled trial of the effects of soy protein containing isoflavones on vascular function in postmenopausal women. American Journal of Clinical Nutrition 2005;81(1):189-95. [PUBMED: 15640479]
Laatikainen 2005
  • Laatikainen T, Critchley J, Vartiainen E, Salomaa V, Ketonen M, Capewell S. Explaining the decline in coronary heart disease mortality in Finland between 1982 and 1997. American Journal of Epidemiology 2005;162(8):764-73. [PUBMED: 16150890]
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Liberati 2009
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Liu 2006
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Liu 2010
  • Liu B, Qin L, Liu A, Uchiyama S, Ueno T, Li X, et al. Prevalence of the equol-producer phenotype and its relationship with dietary isoflavone and serum lipids in healthy Chinese adults. Journal of Epidemiology 2010;20(5):377-84. [PUBMED: 20671375]
Setchell 2002
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Setchell 2010
Shimazu 2010
  • Shimazu T, Inoue M, Sasazuki S, Iwasaki M, Sawada N, Yamaji T, et al. Isoflavone intake and risk of lung cancer: a prospective cohort study in Japan. American Journal of Clinical Nutrition 2010;91(3):722-8. [PUBMED: 20071645]
Sterne 2001
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Taku 2007
  • Taku K, Umegaki K, Sato Y, Taki Y, Endoh K, Watanabe S. Soy isoflavones lower serum total and LDL cholesterol in humans: a meta-analysis of 11 randomized controlled trials. American Journal of Clinical Nutrition 2007;85(4):1148-56. [PUBMED: 17413118]
Taku 2008
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Unfer 2004
  • Unfer V, Casini ML, Costabile L, Mignosa M, Gerli S, Di Renzo GC. Endometrial effects of long-term treatment with phytoestrogens: a randomized, double-blind, placebo-controlled study. Fertility and Sterility 2004;82(1):145-8. [PUBMED: 15237003]
Weggemans 2003
Zhan 2005
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Zhuo 2004
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