Diagnostic Test Accuracy Protocol

PET-CT for assessing mediastinal lymph node involvement in patients with suspected resectable non-small cell lung cancer

  1. Mia Schmidt-Hansen1,*,
  2. David R Baldwin2,
  3. Elise Collins1,
  4. Javier Zamora3,
  5. Víctor Abraira3

Editorial Group: Cochrane Lung Cancer Group

Published Online: 7 DEC 2011

DOI: 10.1002/14651858.CD009519

How to Cite

Schmidt-Hansen M, Baldwin DR, Collins E, Zamora J, Abraira V. PET-CT for assessing mediastinal lymph node involvement in patients with suspected resectable non-small cell lung cancer (Protocol). Cochrane Database of Systematic Reviews 2011, Issue 12. Art. No.: CD009519. DOI: 10.1002/14651858.CD009519.

Author Information

  1. 1

    National Collaborating Centre for Cancer, Cardiff, UK

  2. 2

    Nottingham University Hospitals, City Campus, Adult Cystic Fibrosis Unit, Nottingham, UK

  3. 3

    (b) CIBER Epidemiologia y Salud Publica (CIBERESP), (a) Unidad de Bioestadística, Hospital Ramón y Cajal, Madrid, Spain

*Mia Schmidt-Hansen, National Collaborating Centre for Cancer, 2nd Floor, Park House, Greyfriars Road., Cardiff, CF10 3AF, UK. Mia.Schmidt-Hansen@wales.nhs.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 7 DEC 2011

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

To examine the accuracy of integrated PET-CT for mediastinal staging of patients with suspected or confirmed NSCLC which is potentially suitable for treatment with curative intent.   

To assess potential sources of heterogeneity including study design (e.g. retrospective/prospective, consecutive/random series), patient populations (number and characteristics, e.g. T- and N-stage, significant nodes on prior CT, country), different cut-off values for test positivity (malignancy), differences in PET-CT image acquisition and/or scanning equipment and potential differences in reference standard (mediastinoscopy/pathological or surgical staging).

See 'Secondary objectives'.