This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows:
To examine the accuracy of integrated PET-CT for mediastinal staging of patients with suspected or confirmed NSCLC which is potentially suitable for treatment with curative intent.
To assess potential sources of heterogeneity including study design (e.g. retrospective/prospective, consecutive/random series), patient populations (number and characteristics, e.g. T- and N-stage, significant nodes on prior CT, country), different cut-off values for test positivity (malignancy), differences in PET-CT image acquisition and/or scanning equipment and potential differences in reference standard (mediastinoscopy/pathological or surgical staging).
See 'Secondary objectives'.