Intervention Review

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Interventions for preventing delirium in older people in institutional long-term care

  1. Andrew Clegg1,*,
  2. Najma Siddiqi2,
  3. Anne Heaven3,
  4. John Young4,
  5. Rachel Holt1

Editorial Group: Cochrane Dementia and Cognitive Improvement Group

Published Online: 31 JAN 2014

Assessed as up-to-date: 21 APR 2013

DOI: 10.1002/14651858.CD009537.pub2


How to Cite

Clegg A, Siddiqi N, Heaven A, Young J, Holt R. Interventions for preventing delirium in older people in institutional long-term care. Cochrane Database of Systematic Reviews 2014, Issue 1. Art. No.: CD009537. DOI: 10.1002/14651858.CD009537.pub2.

Author Information

  1. 1

    University of Leeds, Academic Unit of Elderly Care and Rehabilitation, Leeds, UK

  2. 2

    Bradford District Care Trust & University of Leeds, Academic Unit of Psychiatry and Behavioural Sciences, Keighley, UK

  3. 3

    Bradford District Care Trust, Bradford Institute for Health Research, Bradford, UK

  4. 4

    Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Trust, Academic Unit of Elderly Care and Rehabilitation, Bradford, UK

*Andrew Clegg, Academic Unit of Elderly Care and Rehabilitation, University of Leeds, Leeds, LS2 9JT, UK. andrewpaulclegg@yahoo.co.uk. a.p.clegg@leeds.ac.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 31 JAN 2014

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Culp 2003 {published data only}
Lapane 2011 {published data only}
  • Lapane KL, Hughes CM, Daiello LA, Cameron KA, Feinberg J. Effect of a pharmacist-led multicomponent intervention focusing on the medication monitoring phase to prevent potential adverse drug events in nursing homes. Journal of the American Geriatrics Society 2011;59(7):1238-45.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Greendyke 1986 {published data only}
  • Greendyke RM, Kanter DR, Schuster DB, Verstreate S, Wootton J. Propranolol treatment of assaultive patients with organic brain disease. a double-blind crossover, placebo-controlled study. Journal of Nervous and Mental Disease 1986;174(5):290-4.
Grover 2011 {published data only}
  • Grover S, Kumar V, Chakrabarti S. Comparative efficacy study of haloperidol, olanzapine and risperidone in delirium. Journal of Psychosomatic Research 2011;71(4):277-81.
Hofferberth 1989 {published data only}
  • Hofferberth B. The effect of Ginkgo biloba extract on neurophysiological and psychometric measurement results in patients with psychotic organic brain syndrome. A double-blind study against placebo. Arzneimittel-Forschung 1989;39(8):918-22.
Isaia 2009 {published data only}
  • Isaia G, Astengo MA, Tibaldi V, Zanocchi M, Bardelli B, Obialero R, et al. Delirium in elderly home-treated patients: a prospective study with 6-month follow-up. Age 2009;31(2):109-17.
Kim 2010 {published data only}
Marcantonio 2010 {published data only}
Mittal 2004 {published data only}
  • Mittal D, Jimerson NA, Neely EP, Johnson WD, Kennedy RE, Torres RA, et al. Risperidone in the treatment of delirium: results from a prospective open-label trial. Journal of Clinical Psychiatry 2004;65(5):662-7.
Moretti 2004 {published data only}
  • Moretti R, Torre P, Antonello RM, Cattaruzza T, Cazzato G. Cholinesterase inhibition as a possible therapy for delirium in vascular dementia: a controlled, open 24-month study of 246 patients. American Journal of Alzheimer's Disease and Other Dementias 2004;19(6):333-9.
Overshott 2010 {published data only}
  • Overshott R, Vernon M, Morris J, Burns A. Rivastigmine in the treatment of delirium in older people: a pilot study. International Psychogeriatrics 2010;22(5):812-8.
Pellfolk 2010 {published data only}
Tahir 2010 {published data only}
  • Tahir TA, Eeles E, Karapareddy V, Muthuvelu P, Chapple S, Phillips B, et al. A randomized controlled trial of quetiapine versus placebo in the treatment of delirium. Journal of Psychosomatic Research 2010;69(5):485-90.
Ushijima 2008 {published data only}
Yoon 2011 {published data only}

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Siddiqi 2012 {published data only}
  • Siddiqi N. PiTSTOP: Pilot trial of 'Stop Delirium!' in older people. ISRCTN27972532 2012.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Alagiakrishnan 2004
Ames 2005
  • Ames D. Nursing homes. Psychiatry 2005;4(2):79-82.
APA 1980
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APA 1987
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APA 1994
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APA 2013
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Armstrong-Esther 1996
Clark 1996
  • Clark CM, Ewbank DC. Performance of the Dementia Severity Rating Scale: a caregiver questionnaire for rating severity in Alzheimer disease. Alzheimer Disease and Associated Disorders 1996;10(1):31-9.
Clegg 2011
Cochrane 2011
  • Higgins JPT, Altman DG (editors). Chapter 8. Assessing risk of bias in included studies in: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Cole 2012
Dosa 2007
Hshieh 2008
  • Hshieh TT, Fong TJ, Marcantonio ER, Inouye SK. Cholinergic deficiency hypothesis in delirium: synthesis of current evidence. Journal of Gerontology: Medical Sciences 2008;63A(7):764-72.
Inouye 1990
  • Inouye SK, Van Dyck CH, Alessi CA, Balkin S, Siegal AP, Horwitz RI. Clarifying confusion: the confusion assessment method. A new method for detection of delirium. Annals of Internal Medicine 1990;113(12):941-8.
Inouye 1996
Inouye 1998
Inouye 1999
  • Inouye SK, Bogardus ST Jr, Charpentier PA, Leo-Summers L, Acampora D, et al. A multicomponent intervention to prevent delirium in hospitalized older patients. New England Journal of Medicine 1999;340(9):669-76.
Inouye 2006
Kalisvaart 2005
Leslie 2008
  • Leslie DL, Marcantonio ER, Zhang Y, Leo-Summers L, Inouye SK. One year health-care costs associated with delirium in the elderly population. Archives of Internal Medicine 2008;168(1):27-32.
Marcantonio 2001
McCusker 2011
  • McCusker J, Cole MG, Voyer P, Monette J, Champoux N, Ciampi A, et al. Prevalence and incidence of delirium in long-term care. International Journal of Geriatric Psychiatry 2011;26(11):1152-61.
McCusker 2013
Morris 1993
Neelon 1996
NICE 2010
  • National Institute for Health and Clinical Excellence (NICE). Delirium: diagnosis, prevention and management. NICE Clinical Guideline 103. www.nice.org.uk/nicemedia/live/13060/49909/49909.pdf (accessed 16th January 2014) 2010.
RevMan 2012 [Computer program]
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Rockwood 1999
Siddiqi 2007
Siddiqi 2009
  • Siddiqi N, Clegg A, Young J. Delirium in care homes. Reviews in Clinical Gerontology 2009;19:309-16.
Soule 2005
  • Soule A, Babb P, Evandrou M, Balchin S, Zealey L. Focus on older people. www.statistics.gov.uk/downloads/theme_compendia/foop05/Olderpeople2005.pdf (accessed 16th January 2014) 2005; Vol. National Statistics: Department for Work and Pensions. London, UK.
Tabet 2009
Trzepacz 1988
Voyer 2010
  • Voyer P, Richard S, Doucet L, Cyr N, Carmichael PH. Examination of the multifactorial model of delirium among long-term care residents with dementia. Geriatric Nursing 2010;31(2):105-14.
WHO 1992
  • World Health Organization. The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines. Vol. 10, Geneva: World Health Organization, 1992.
Witlox 2010
  • Witlox J, Eurelings LSM, De Jonghe JFM, Kalisvaart KJ, Van Gool WA. Delirium in elderly patients and the risk of post-discharge mortality, institutionalization, and dementia. JAMA 2010;304(4):443-51.

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Clegg 2012
  • Clegg A, Siddiqi N, Holt R, Young J. Interventions for preventing delirium in older people in institutional long-term care (protocol). Cochrane Database of Systematic Reviews 2012, Issue 1. [DOI: 10.1002/14651858.CD009537]