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Anticholinergic medication for non-clozapine neuroleptic-induced hypersalivation in people with schizophrenia

  1. Adib Essali1,*,
  2. Anas Rihawi2,
  3. Mohammad Altujjar3,
  4. Bishr Alhafez4,
  5. Amjad Tarboush4,
  6. Nahla Alhaj Hasan4

Editorial Group: Cochrane Schizophrenia Group

Published Online: 19 DEC 2013

Assessed as up-to-date: 7 DEC 2012

DOI: 10.1002/14651858.CD009546.pub2


How to Cite

Essali A, Rihawi A, Altujjar M, Alhafez B, Tarboush A, Alhaj Hasan N. Anticholinergic medication for non-clozapine neuroleptic-induced hypersalivation in people with schizophrenia. Cochrane Database of Systematic Reviews 2013, Issue 12. Art. No.: CD009546. DOI: 10.1002/14651858.CD009546.pub2.

Author Information

  1. 1

    Modern Psychiatry Hospital, Psychiatry Centre, Damascus, Syrian Arab Republic

  2. 2

    St.Elizabeth's Medical Center, Internal Medicine, Brighton, Massachusetts, USA

  3. 3

    Aleppo University, Faculty of Medicine, Aleppo, Syrian Arab Republic

  4. 4

    Damascus University, Faculty of Medicine, Damascus, Syrian Arab Republic

*Adib Essali, Psychiatry Centre, Modern Psychiatry Hospital, 27 Al Zahrawi Street, Rawda, Damascus, Syrian Arab Republic. adib-essali@hotmail.com. adib-essali@hotmail.com.

Publication History

  1. Publication Status: New
  2. Published Online: 19 DEC 2013

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Characteristics of excluded studies [ordered by study ID]

StudyReason for exclusion

Bai 2001Allocation: randomised.

Participants: people with clozapine-induced hypersalivation.

Hui 2002Allocation: randomised.

Participants: people with schizophrenia, mood disorders or other mental disorders and patients with clozapine-induced and non-clozapine-induced hypersalivation.

Interventions.

  1. Radix Codonopsis Pilosulae (Dang Shen), Rhizoma Atractylodis Macrocephalae (Bai Zhu), Sclerotium Poriae Cocos (Fu Ling), Pericarpium Citri Reticulatae (Chen Pi), lime processed Rhizoma Pinelliae Ternatae (Ban Xia) and Radix Glycyrrhizae (Gan Cao).
  2. Artane or phenergan.

ISRCTN47146067 2010Allocation: randomised.

Participants: people with clozapine-induced hypersalivation.

Reinstein 1999Allocation: randomised.

Participants: people with clozapine-induced hypersalivation.

 
Table 1. Prevalence of Increased Salivation, Short-term Results (by 12 Weeks or Less) (adopted from Ozbilen 2009)

CompoundnRCTs% (95% CI)

Placebo403107.7 (5 to 11)

Clozapine5591632.7 (29 to 37)

Zotepine53141.5 (29 to 55)

Zuclopenthixol hydrochloride66224.2 (16 to 36)

Haloperidol11151218.4 (16 to 21)

Thioridazine66215.2 (8 to 26)

Chlorpromazine4991214.2 (11 to 18)

Trifluoperazine44613.6 (6 to 27)

Molindone4229.5 (4 to 22)

Bromperidol depot2713.7 (1 to 18)

Olanzapine185758.2 (7 to 10)

Fluphenazine hydrochloride11028.2 (4 to 15)

Amisulpride11517.8 (4 to 14)

Sulpiride15467.1 (4 to 12)

Risperidone depot31725.7 (4 to 9)

Perphenazine7435.4 (2 to 13)

Risperidone32533.7 (2 to 6)