Diagnostic Test Accuracy Protocol

Polymerase chain reaction blood tests for the diagnosis of invasive aspergillosis in immunocompromised patients

  1. Mario Cruciani1,*,
  2. Carlo Mengoli2,
  3. Juergen Loeffler3,
  4. Peter Donnelly4,
  5. Rosemary Barnes5,
  6. Brian L Jones6,
  7. Lena Klingspor7,
  8. Oliver Morton8,
  9. Johan Maertens9

Editorial Group: Cochrane Gynaecological Cancer Group

Published Online: 18 JAN 2012

Assessed as up-to-date: 24 NOV 2011

DOI: 10.1002/14651858.CD009551


How to Cite

Cruciani M, Mengoli C, Loeffler J, Donnelly P, Barnes R, Jones BL, Klingspor L, Morton O, Maertens J. Polymerase chain reaction blood tests for the diagnosis of invasive aspergillosis in immunocompromised patients (Protocol). Cochrane Database of Systematic Reviews 2012, Issue 1. Art. No.: CD009551. DOI: 10.1002/14651858.CD009551.

Author Information

  1. 1

    ULSS 20 Verona, Center of Community Medicine and Infectious Diseases Service, Verona, Italy

  2. 2

    Università di Padova, Department of Histology, Microbiology and Medical Biotechnology, PADOVA, Italy

  3. 3

    Julius-Maximilians-Universitat, Medizinische Klinik II, Wurzburg, Germany

  4. 4

    Nijmegen Institute for Infection, Department of Haematology, Nijmegen, Netherlands

  5. 5

    School of Medicine Cardiff University, Infection, Immunity and Biochemistry, Cardiff, Wales, UK

  6. 6

    Glasgow Royal Infirmary & University of Glasgow, Department of Medical Microbiology, Glasgow, UK

  7. 7

    Division of Clinical Microbiology, Department of Laboratory Medicine, Stockholm, Sweden

  8. 8

    Trinity College Dublin, Department of Clinical Microbiology, Dublin, Ireland

  9. 9

    Acute Leukemia and Stem Cell Transplantation Unit, Department of Hematology, Leuven, Belgium

*Mario Cruciani, Center of Community Medicine and Infectious Diseases Service, ULSS 20 Verona, Via Germania, 20, Verona, 37135, Italy. crucianimario@virgilio.it.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 18 JAN 2012

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

To provide an overall summary of the diagnostic accuracy of PCR-based tests on blood specimens for the diagnosis of IA in the immunocompromised host.

When studies included in the analysis also compare the diagnostic performance of PCR techniques and the GM-ELISA assay, we will comparatively evaluate the diagnostic performance of PCR-based tests and GM-ELISA assays. However, since is not an objective of this review to identify all the studies dealing with GM-ELISA assays and IA, only within-study comparisons will be included in the review.

If sufficient data are available, we will explore possible sources of heterogeneity and subgroup differences.