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Rapid screening and diagnostic tests for human schistosomiasis in endemic areas

  • Protocol
  • Diagnostic

Authors


Abstract

This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows:

To obtain summary estimates of the diagnostic accuracy of urine reagent strip tests for haematuria/ protenuria/ leukocyturia in detecting active S. haematobium infection, using microscopy as the reference standard.  

To obtain summary estimates of the diagnostic accuracy of a POC urine CCA test (urine CCA dipstick) for the detection of an active Schistosoma infection in geographical regions endemic for S. mansoni or S. haematobium, or both, using microscopy of stool or urine, or both, as the reference standard. 

To obtain summary estimates of the diagnostic accuracy of ELISA for CCA or CAA in serum or urine for the detection of active Schistosoma infection in geographical regions endemic for S. mansoni or S. haematobium, or both.

We will investigate whether age and sex of participants, prevalence of infection, stage of infection, intensity of infection, mixed infections, effect of treatment with praziquantel and number of urine or stool samples used can explain the expected heterogeneity in test accuracy estimates.