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Addition of anti-leukotriene agents to inhaled corticosteroids in children with persistent asthma

  1. Bhupendrasinh F Chauhan1,*,
  2. Raja Ben Salah1,
  3. Francine M Ducharme2,3

Editorial Group: Cochrane Airways Group

Published Online: 2 OCT 2013

Assessed as up-to-date: 12 JAN 2013

DOI: 10.1002/14651858.CD009585.pub2


How to Cite

Chauhan BF, Ben Salah R, Ducharme FM. Addition of anti-leukotriene agents to inhaled corticosteroids in children with persistent asthma. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD009585. DOI: 10.1002/14651858.CD009585.pub2.

Author Information

  1. 1

    Research Centre, CHU Sainte-Justine, Clinical Research Unit on Childhood Asthma, Montreal, Canada

  2. 2

    University of Montreal, Department of Paediatrics, Montreal, Québec, Canada

  3. 3

    CHU Sainte-Justine, Research Centre, Montreal, Canada

*Bhupendrasinh F Chauhan, Clinical Research Unit on Childhood Asthma, Research Centre, CHU Sainte-Justine, 3175, Cote Sainte-Catherine, Montreal, Canada. bhupendra_chauhan@rediffmail.com. bhupendrasinh.chauhan@recherche-ste-justine.qc.ca.

Publication History

  1. Publication Status: New
  2. Published Online: 2 OCT 2013

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[Figure 1]
Figure 1. Study selection diagram
[Figure 2]
Figure 2. 'Risk of bias' summary: review authors' judgements about each 'Risk of bias' item for each included study
[Figure 3]
Figure 3. Forest plot of comparison: 1 Anti-leukotrienes and ICS versus same dose of ICS, outcome: 1.1 Participants with one or more exacerbations requiring oral corticosteroids
[Figure 4]
Figure 4. Forest plot of comparison: 2 Anti-leukotrienes and ICS versus higher dose of ICS, outcome: 2.1 Participants with one or more exacerbations requiring oral corticosteroids
[Analysis 1.1]
Analysis 1.1. Comparison 1 Anti-leukotrienes and inhaled corticosteroids versus same dose of inhaled corticosteroids, Outcome 1 Participants with 1 or more exacerbations requiring oral corticosteroids.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Anti-leukotrienes and inhaled corticosteroids versus same dose of inhaled corticosteroids, Outcome 2 Participants with exacerbations requiring hospital admission.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Anti-leukotrienes and inhaled corticosteroids versus same dose of inhaled corticosteroids, Outcome 3 Change from baseline FEV₁ (%).
[Analysis 1.4]
Analysis 1.4. Comparison 1 Anti-leukotrienes and inhaled corticosteroids versus same dose of inhaled corticosteroids, Outcome 4 Change from baseline AM PEFR (L/min).
[Analysis 1.5]
Analysis 1.5. Comparison 1 Anti-leukotrienes and inhaled corticosteroids versus same dose of inhaled corticosteroids, Outcome 5 Change from baseline PM PEFR (L/min).
[Analysis 1.6]
Analysis 1.6. Comparison 1 Anti-leukotrienes and inhaled corticosteroids versus same dose of inhaled corticosteroids, Outcome 6 Overall withdrawals.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Anti-leukotrienes and inhaled corticosteroids versus same dose of inhaled corticosteroids, Outcome 7 Withdrawal because of specific reasons.
[Analysis 1.8]
Analysis 1.8. Comparison 1 Anti-leukotrienes and inhaled corticosteroids versus same dose of inhaled corticosteroids, Outcome 8 Serious adverse effects.
[Analysis 1.9]
Analysis 1.9. Comparison 1 Anti-leukotrienes and inhaled corticosteroids versus same dose of inhaled corticosteroids, Outcome 9 Death.
[Analysis 1.10]
Analysis 1.10. Comparison 1 Anti-leukotrienes and inhaled corticosteroids versus same dose of inhaled corticosteroids, Outcome 10 Overall adverse effects.
[Analysis 1.11]
Analysis 1.11. Comparison 1 Anti-leukotrienes and inhaled corticosteroids versus same dose of inhaled corticosteroids, Outcome 11 Specific adverse effects.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Anti-leukotrienes and inhaled corticosteroids versus higher dose of inhaled corticosteroids, Outcome 1 Participants with 1 or more exacerbations requiring oral corticosteroids.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Anti-leukotrienes and inhaled corticosteroids versus higher dose of inhaled corticosteroids, Outcome 2 Participants with exacerbations requiring hospital admission.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Anti-leukotrienes and inhaled corticosteroids versus higher dose of inhaled corticosteroids, Outcome 3 Overall withdrawals.