Xpert MTB/RIF test for detection of pulmonary tuberculosis and rifampicin resistance

  • Protocol
  • Diagnostic

Authors


Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

Primary objectives

Review question A: To obtain summary estimates of the diagnostic accuracy of Xpert MTB/RIF for the diagnosis of pulmonary TB, using solid or liquid culture as a reference standard.

Purpose of index test:

A.1 Xpert MTB/RIF as a replacement test for smear microscopy.

A.2. Xpert MTB/RIF as an add-on test after smear microscopy.

Review question B: To obtain summary estimates of the diagnostic accuracy of Xpert MTB/RIF for detection of rifampicin resistance, using solid or liquid culture as a reference standard (WHO 2008).  

Purpose of index test:

B.1 Xpert MTB/RIF as a replacement test for WHO-approved tests for detection of rifampicin resistance.

  1. To summarize evidence on time to treatment initiation.

  2. To summarize evidence on time to diagnosis.

Although these secondary outcomes will not be systematically reviewed, we will extract data when present in the included accuracy studies.

We will investigate whether HIV-infection status; sputum smear status; country income status; setting; or storage conditions of specimen can explain the expected heterogeneity in estimates of test sensitivity and specificity.