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Diagnostic Test Accuracy Protocol

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Xpert MTB/RIF test for detection of pulmonary tuberculosis and rifampicin resistance

  1. Hojoon Sohn2,
  2. Madhukar Pai3,
  3. Nandini Dendukuri4,
  4. Lorie A Kloda5,
  5. Catharina C Boehme6,
  6. Karen R Steingart1,*

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 18 JAN 2012

DOI: 10.1002/14651858.CD009593

How to Cite

Sohn H, Pai M, Dendukuri N, Kloda LA, Boehme CC, Steingart KR. Xpert MTB/RIF test for detection of pulmonary tuberculosis and rifampicin resistance (Protocol). Cochrane Database of Systematic Reviews 2012, Issue 1. Art. No.: CD009593. DOI: 10.1002/14651858.CD009593.

Author Information

  1. 1

    University of Washington, School of Public Health, Department of Health Services, Seattle, Washington, USA

  2. 2

    McGill University, Department of Epidemiology & Biostatistics, Montreal, Quebec, Canada

  3. 3

    McGill University, Dept of Epidemiology and Biostatistics, Montreal, QC, Canada

  4. 4

    McGill University, Department of Epidemiology, Biostatistics, and Occupational Health, Montreal, Canada

  5. 5

    McGill University, Life Sciences Library, Montreal, Quebec, Canada

  6. 6

    FIND, Geneva, Switzerland

*Karen R Steingart, Department of Health Services, University of Washington, School of Public Health, Seattle, Washington, 98195-7230, USA. karenst@uw.edu.

Publication History

  1. Publication Status: New
  2. Published Online: 18 JAN 2012

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

Primary objectives

Review question A: To obtain summary estimates of the diagnostic accuracy of Xpert MTB/RIF for the diagnosis of pulmonary TB, using solid or liquid culture as a reference standard.

Purpose of index test:

A.1 Xpert MTB/RIF as a replacement test for smear microscopy.

A.2. Xpert MTB/RIF as an add-on test after smear microscopy.

Review question B: To obtain summary estimates of the diagnostic accuracy of Xpert MTB/RIF for detection of rifampicin resistance, using solid or liquid culture as a reference standard (WHO 2008).  

Purpose of index test:

B.1 Xpert MTB/RIF as a replacement test for WHO-approved tests for detection of rifampicin resistance.

  1. To summarize evidence on time to treatment initiation.
  2. To summarize evidence on time to diagnosis.

Although these secondary outcomes will not be systematically reviewed, we will extract data when present in the included accuracy studies.

We will investigate whether HIV-infection status; sputum smear status; country income status; setting; or storage conditions of specimen can explain the expected heterogeneity in estimates of test sensitivity and specificity.