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The role of maintenance therapy in acute promyelocytic leukemia in the first complete remission

  1. Eli Muchtar1,*,
  2. Liat Vidal1,
  3. Ron Ram2,
  4. Anat Gafter-Gvili1,
  5. Ofer Shpilberg2,
  6. Pia Raanani2

Editorial Group: Cochrane Haematological Malignancies Group

Published Online: 28 MAR 2013

Assessed as up-to-date: 17 JUL 2012

DOI: 10.1002/14651858.CD009594.pub2


How to Cite

Muchtar E, Vidal L, Ram R, Gafter-Gvili A, Shpilberg O, Raanani P. The role of maintenance therapy in acute promyelocytic leukemia in the first complete remission. Cochrane Database of Systematic Reviews 2013, Issue 3. Art. No.: CD009594. DOI: 10.1002/14651858.CD009594.pub2.

Author Information

  1. 1

    Beilinson Hospital, Rabin Medical Center, Department of Medicine E, Petah Tikva, Israel

  2. 2

    Beilinson Hospital, Rabin Medical Center, Institute of Hematology, Davidoff Center, Petah Tikva, Israel

*Eli Muchtar, Department of Medicine E, Beilinson Hospital, Rabin Medical Center, 39 Jabotinski Street, Petah Tikva, 49100, Israel. muchtare@gmail.com. elim2@clalit.org.il.

Publication History

  1. Publication Status: New
  2. Published Online: 28 MAR 2013

SEARCH

[Figure 1]
Figure 1. Flow diagram.
[Figure 2]
Figure 2. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Figure 3]
Figure 3. Forest plot of comparison: 1 any maintenance compared to observation, outcome: 1.1 Overall survival.
[Figure 4]
Figure 4. Forest plot of comparison: 1 any maintenance compared to observation, outcome: 1.2 Disease-free survival.
[Figure 5]
Figure 5. Forest plot of comparison: 2 ATRA-based maintenance compared to non-ATRA based maintenance, outcome: 2.1 Overall survival.
[Figure 6]
Figure 6. Forest plot of comparison: 2 ATRA-based maintenance compared to non-ATRA based maintenance, outcome: 2.2 Disease-free survival.
[Figure 7]
Figure 7. Forest plot of comparison: 3 Maintenance with ATRA alone compared to maintenance with ATRA and chemotherapy, outcome: 3.1 Overall survival.
[Figure 8]
Figure 8. Forest plot of comparison: 3 Maintenance with ATRA alone compared to maintenance with ATRA and chemotherapy, outcome: 3.2 Disease-free survival.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Any maintenance compared to observation, Outcome 1 Overall survival.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Any maintenance compared to observation, Outcome 2 Disease-free survival.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Any maintenance compared to observation, Outcome 3 Relapse rate.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Any maintenance compared to observation, Outcome 4 Low intensity maintenance vs. observation: Overall survival.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Any maintenance compared to observation, Outcome 5 Low intensity maintenance vs. observation: Disease-free survival.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Any maintenance compared to observation, Outcome 6 Low intensity maintenance vs. observation: Relapse rate.
[Analysis 2.1]
Analysis 2.1. Comparison 2 ATRA-based maintenance compared to non-ATRA based maintenance, Outcome 1 Overall survival.
[Analysis 2.2]
Analysis 2.2. Comparison 2 ATRA-based maintenance compared to non-ATRA based maintenance, Outcome 2 Disease-free survival.
[Analysis 2.3]
Analysis 2.3. Comparison 2 ATRA-based maintenance compared to non-ATRA based maintenance, Outcome 3 Relapse rate.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Maintenance with ATRA alone compared to maintenance with ATRA and chemotherapy, Outcome 1 Overall survival.
[Analysis 3.2]
Analysis 3.2. Comparison 3 Maintenance with ATRA alone compared to maintenance with ATRA and chemotherapy, Outcome 2 Disease-free survival.
[Analysis 4.1]
Analysis 4.1. Comparison 4 ATRA alone maintenance compared to ATRA and chemotherapy maintenance in pediatric patients, Outcome 1 Overall survival.
[Analysis 4.2]
Analysis 4.2. Comparison 4 ATRA alone maintenance compared to ATRA and chemotherapy maintenance in pediatric patients, Outcome 2 Disease-free survival.
[Analysis 5.1]
Analysis 5.1. Comparison 5 Subgroup analysis: overall survival by type of remission confirmation, Outcome 1 Any maintenance compare to observation.
[Analysis 5.2]
Analysis 5.2. Comparison 5 Subgroup analysis: overall survival by type of remission confirmation, Outcome 2 ATRA based maintenance compare to non-ATRA based maintenance.
[Analysis 5.3]
Analysis 5.3. Comparison 5 Subgroup analysis: overall survival by type of remission confirmation, Outcome 3 ATRA alone maintenance compare to ATRA and chemotherapy maintenance.
[Analysis 6.1]
Analysis 6.1. Comparison 6 Subgroup analysis: disease-free survival by type of remission confirmation, Outcome 1 Any maintenance compare to observation.
[Analysis 6.2]
Analysis 6.2. Comparison 6 Subgroup analysis: disease-free survival by type of remission confirmation, Outcome 2 ATRA based maintenance compare to non-ATRA based maintenance.
[Analysis 6.3]
Analysis 6.3. Comparison 6 Subgroup analysis: disease-free survival by type of remission confirmation, Outcome 3 ATRA alone maintenance compare to ATRA and chemotherapy maintenance.
[Analysis 7.1]
Analysis 7.1. Comparison 7 Subgroup analysis: overall survival by type of prior anthracycline use, Outcome 1 Any maintenance compare to observation.
[Analysis 7.2]
Analysis 7.2. Comparison 7 Subgroup analysis: overall survival by type of prior anthracycline use, Outcome 2 ATRA based maintenance compare to non-ATRA based maintenance.
[Analysis 7.3]
Analysis 7.3. Comparison 7 Subgroup analysis: overall survival by type of prior anthracycline use, Outcome 3 ATRA alone maintenance compare to ATRA and chemotherapy maintenance.
[Analysis 8.1]
Analysis 8.1. Comparison 8 Subgroup analysis: disease-free survival by type of prior anthracycline use, Outcome 1 Any maintenance compare to observation.
[Analysis 8.2]
Analysis 8.2. Comparison 8 Subgroup analysis: disease-free survival by type of prior anthracycline use, Outcome 2 ATRA based maintenance compare to non-ATRA based maintenance.
[Analysis 8.3]
Analysis 8.3. Comparison 8 Subgroup analysis: disease-free survival by type of prior anthracycline use, Outcome 3 ATRA alone maintenance compare to ATRA and chemotherapy maintenance.
[Analysis 9.1]
Analysis 9.1. Comparison 9 Sensitivity analysis: overall survival by method of allocation concealment, allocation generation, Outcome 1 ATRA based maintenance compare to non-ATRA based maintenance.
[Analysis 10.1]
Analysis 10.1. Comparison 10 Sensitivity analysis: disease-free survival by method of allocation concealment, allocation generation, Outcome 1 ATRA based maintenance compare to non-ATRA based maintenance.
[Analysis 11.1]
Analysis 11.1. Comparison 11 Sensitivity analysis: overall survival by duration of follow-up, Outcome 1 Any maintenance compare to observation.
[Analysis 11.2]
Analysis 11.2. Comparison 11 Sensitivity analysis: overall survival by duration of follow-up, Outcome 2 ATRA based maintenance compare to non-ATRA based maintenance.
[Analysis 11.3]
Analysis 11.3. Comparison 11 Sensitivity analysis: overall survival by duration of follow-up, Outcome 3 ATRA alone maintenance compare to ATRA and chemotherapy maintenance.
[Analysis 12.1]
Analysis 12.1. Comparison 12 Sensitivity analysis: disease-free survival by duration of follow-up, Outcome 1 Any maintenance compare to observation.
[Analysis 12.2]
Analysis 12.2. Comparison 12 Sensitivity analysis: disease-free survival by duration of follow-up, Outcome 2 ATRA based maintenance compare to non-ATRA based maintenance.
[Analysis 12.3]
Analysis 12.3. Comparison 12 Sensitivity analysis: disease-free survival by duration of follow-up, Outcome 3 ATRA alone maintenance compare to ATRA and chemotherapy maintenance.
[Analysis 13.1]
Analysis 13.1. Comparison 13 Sensitivity analysis by overall survival (OS) measure method, Outcome 1 ATRA based maintenance compare to non-ATRA based maintenance.
[Analysis 13.2]
Analysis 13.2. Comparison 13 Sensitivity analysis by overall survival (OS) measure method, Outcome 2 ATRA alone maintenance compare to ATRA and chemotherapy maintenance.
[Analysis 14.1]
Analysis 14.1. Comparison 14 Sensitivity analysis by disease-free survival (DFS) measure method, Outcome 1 ATRA based maintenance compare to non-ATRA based maintenance.
[Analysis 15.1]
Analysis 15.1. Comparison 15 Subgroup analysis: survival by subtype of maintenance compared to observation, Outcome 1 Overall survival.
[Analysis 15.2]
Analysis 15.2. Comparison 15 Subgroup analysis: survival by subtype of maintenance compared to observation, Outcome 2 Disease-free survival.