Intervention Review

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Clonidine premedication for postoperative analgesia in children

  1. Paul Lambert1,
  2. Allan M Cyna1,*,
  3. Nicholas Knight2,
  4. Philippa Middleton3

Editorial Group: Cochrane Anaesthesia, Critical and Emergency Care Group

Published Online: 28 JAN 2014

Assessed as up-to-date: 21 DEC 2012

DOI: 10.1002/14651858.CD009633.pub2


How to Cite

Lambert P, Cyna AM, Knight N, Middleton P. Clonidine premedication for postoperative analgesia in children. Cochrane Database of Systematic Reviews 2014, Issue 1. Art. No.: CD009633. DOI: 10.1002/14651858.CD009633.pub2.

Author Information

  1. 1

    Women's and Children's Hospital, Department of Women's Anaesthesia, Adelaide, South Australia, Australia

  2. 2

    Royal Adelaide Hospital, Department of Anaesthesia, Adelaide, SA, Australia

  3. 3

    The University of Adelaide, ARCH: Australian Research Centre for Health of Women and Babies, The Robinson Institute, Discipline of Obstetrics and Gynaecology, Adelaide, South Australia, Australia

*Allan M Cyna, Department of Women's Anaesthesia, Women's and Children's Hospital, 72 King William Road, Adelaide, South Australia, 5006, Australia. allan.cyna@health.sa.gov.au.

Publication History

  1. Publication Status: New
  2. Published Online: 28 JAN 2014

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[Figure 1]
Figure 1. Study flow diagram.
[Figure 2]
Figure 2. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Figure 3]
Figure 3. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Clonidine versus placebo or no treatment, Outcome 1 Number requiring additional analgesia at any time postoperatively.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Clonidine versus placebo or no treatment, Outcome 2 Number pain-free in PACU.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Clonidine versus placebo or no treatment, Outcome 3 Postoperative pain score.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Clonidine versus midazolam, Outcome 1 Number pain-free in PACU.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Clonidine versus midazolam, Outcome 2 Nausea and vomiting.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Clonidine versus midazolam, Outcome 3 Postoperative shivering.
[Analysis 2.4]
Analysis 2.4. Comparison 2 Clonidine versus midazolam, Outcome 4 Time to discharge from PACU.
[Analysis 3.1]
Analysis 3.1. Comparison 3 High dose versus low dose clonidine, Outcome 1 Number requiring additional analgesia required postoperatively.