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Red cell transfusion management for patients undergoing cardiac surgery for congenital heart disease

  1. Kirstin L Wilkinson1,*,
  2. Susan J Brunskill2,
  3. Carolyn Doree2,
  4. Marialena Trivella3,
  5. Ravi Gill4,
  6. Michael F Murphy5

Editorial Group: Cochrane Heart Group

Published Online: 7 FEB 2014

Assessed as up-to-date: 11 DEC 2013

DOI: 10.1002/14651858.CD009752.pub2


How to Cite

Wilkinson KL, Brunskill SJ, Doree C, Trivella M, Gill R, Murphy MF. Red cell transfusion management for patients undergoing cardiac surgery for congenital heart disease. Cochrane Database of Systematic Reviews 2014, Issue 2. Art. No.: CD009752. DOI: 10.1002/14651858.CD009752.pub2.

Author Information

  1. 1

    Southampton University NHS Hospital, Paediatric and Adult Cardiothoracic Anaesthesia, Southampton, UK

  2. 2

    NHS Blood and Transplant, Systematic Review Initiative, Oxford, Oxon, UK

  3. 3

    University of Oxford, Centre for Statistics in Medicine, Oxford, UK

  4. 4

    Southampton University Hospital NHS Trust, Department of Anaesthetics, Southampton, Hampshire, UK

  5. 5

    John Radcliffe Hospital, NHS Blood and Transplant, Oxford, UK

*Kirstin L Wilkinson, Paediatric and Adult Cardiothoracic Anaesthesia, Southampton University NHS Hospital, Tremona Road, Southampton, SO16 6YD, UK. kirstinwilkinson@hotmail.com.

Publication History

  1. Publication Status: New
  2. Published Online: 7 FEB 2014

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[Figure 1]
Figure 1. Study flow diagram.
[Figure 2]
Figure 2. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 3]
Figure 3. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Comparisons of red cell transfusion at the time of cardiac surgery in people with congenital heart disease, Outcome 1 All-cause mortality: short term (30 days post surgery).
[Analysis 1.2]
Analysis 1.2. Comparison 1 Comparisons of red cell transfusion at the time of cardiac surgery in people with congenital heart disease, Outcome 2 All-cause mortality: long term - at 2 years.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Comparisons of red cell transfusion at the time of cardiac surgery in people with congenital heart disease, Outcome 3 Severe adverse events: cardiac events.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Comparisons of red cell transfusion at the time of cardiac surgery in people with congenital heart disease, Outcome 4 Severe adverse events: acute lung injury.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Comparisons of red cell transfusion at the time of cardiac surgery in people with congenital heart disease, Outcome 5 Severe adverse event: thromboembolism.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Comparisons of red cell transfusion at the time of cardiac surgery in people with congenital heart disease, Outcome 6 Severe adverse events: renal failure (needing renal replacement therapy).
[Analysis 1.7]
Analysis 1.7. Comparison 1 Comparisons of red cell transfusion at the time of cardiac surgery in people with congenital heart disease, Outcome 7 Severe adverse events: infection.
[Analysis 1.8]
Analysis 1.8. Comparison 1 Comparisons of red cell transfusion at the time of cardiac surgery in people with congenital heart disease, Outcome 8 Severe adverse events: haemorrhage (return to theatre for bleeding).
[Analysis 1.9]
Analysis 1.9. Comparison 1 Comparisons of red cell transfusion at the time of cardiac surgery in people with congenital heart disease, Outcome 9 Haematocrit (%)/haemoglobin (g/dL) levels postoperatively.
[Analysis 1.10]
Analysis 1.10. Comparison 1 Comparisons of red cell transfusion at the time of cardiac surgery in people with congenital heart disease, Outcome 10 Volume or number of red cell units transfused.
[Analysis 1.11]
Analysis 1.11. Comparison 1 Comparisons of red cell transfusion at the time of cardiac surgery in people with congenital heart disease, Outcome 11 Number of participants receiving fresh frozen plasma.
[Analysis 1.12]
Analysis 1.12. Comparison 1 Comparisons of red cell transfusion at the time of cardiac surgery in people with congenital heart disease, Outcome 12 Number of participants receiving a platelet transfusion.
[Analysis 1.13]
Analysis 1.13. Comparison 1 Comparisons of red cell transfusion at the time of cardiac surgery in people with congenital heart disease, Outcome 13 Volume or number of other blood products transfused: platelets.
[Analysis 1.14]
Analysis 1.14. Comparison 1 Comparisons of red cell transfusion at the time of cardiac surgery in people with congenital heart disease, Outcome 14 Volume or number of other blood products transfused: cryoprecipitate.
[Analysis 1.15]
Analysis 1.15. Comparison 1 Comparisons of red cell transfusion at the time of cardiac surgery in people with congenital heart disease, Outcome 15 Volume or number of other blood products transfused: fresh frozen plasma.
[Analysis 1.16]
Analysis 1.16. Comparison 1 Comparisons of red cell transfusion at the time of cardiac surgery in people with congenital heart disease, Outcome 16 Postoperative chest drain output.
[Analysis 1.17]
Analysis 1.17. Comparison 1 Comparisons of red cell transfusion at the time of cardiac surgery in people with congenital heart disease, Outcome 17 Duration of mechanical ventilation.
[Analysis 1.18]
Analysis 1.18. Comparison 1 Comparisons of red cell transfusion at the time of cardiac surgery in people with congenital heart disease, Outcome 18 Duration of intensive care unit stay.
[Analysis 1.19]
Analysis 1.19. Comparison 1 Comparisons of red cell transfusion at the time of cardiac surgery in people with congenital heart disease, Outcome 19 Lactate Levels (mmol/L).
[Analysis 1.20]
Analysis 1.20. Comparison 1 Comparisons of red cell transfusion at the time of cardiac surgery in people with congenital heart disease, Outcome 20 Sodium (Na+) levels (mmol/L).
[Analysis 1.21]
Analysis 1.21. Comparison 1 Comparisons of red cell transfusion at the time of cardiac surgery in people with congenital heart disease, Outcome 21 Potassium (K+) levels (mmol/L).
[Analysis 1.22]
Analysis 1.22. Comparison 1 Comparisons of red cell transfusion at the time of cardiac surgery in people with congenital heart disease, Outcome 22 Blood glucose (mg/dL).