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Extracorporeal photopheresis versus standard treatment for acute graft-versus-host disease after haematopoietic stem cell transplantation in paediatric patients

  1. Marcus Weitz1,*,
  2. Brigitte Strahm2,
  3. Joerg J Meerpohl3,
  4. Dirk Bassler4

Editorial Group: Cochrane Childhood Cancer Group

Published Online: 25 FEB 2014

Assessed as up-to-date: 11 MAR 2013

DOI: 10.1002/14651858.CD009759.pub2

How to Cite

Weitz M, Strahm B, Meerpohl JJ, Bassler D. Extracorporeal photopheresis versus standard treatment for acute graft-versus-host disease after haematopoietic stem cell transplantation in paediatric patients. Cochrane Database of Systematic Reviews 2014, Issue 2. Art. No.: CD009759. DOI: 10.1002/14651858.CD009759.pub2.

Author Information

  1. 1

    University Children's Hospital, Pediatric Nephrology, Zurich, Switzerland

  2. 2

    University Medical School Freiburg, Pediatric Hematology and Oncology Centre for Pediatrics and Adolescent Medicine, Freiburg, Germany

  3. 3

    Medical Center - University of Freiburg, German Cochrane Centre, Freiburg, Germany

  4. 4

    University Children's Hospital, Department of Neonatology, Tuebingen, Germany

*Marcus Weitz, Pediatric Nephrology, University Children's Hospital, Steinwiesstrasse 75, Zurich, 8032, Switzerland.

Publication History

  1. Publication Status: New
  2. Published Online: 25 FEB 2014


This is not the most recent version of the article. View current version (15 DEC 2015)


References to studies excluded from this review

  1. References to studies excluded from this review
  2. References to ongoing studies
  3. Additional references
Apisarnthanarax 2003 {published data only}
  • Apisarnthanarax N, Donato M, Korbling M, Couriel D, Gajewski J, Giralt S, et al. Extracorporeal photopheresis therapy in the management of steroid-refractory or steroid-dependent cutaneous chronic graft-versus-host disease after allogeneic stem cell transplantation: feasibility and results. Bone Marrow Transplantation 2003;31(6):459-65.
Balda 1996 {published data only}
  • Balda B, Konstantinov A, Starz H, Gneklow A, Heidemann P. Extracorporeal photochemotherapy as an effective treatment modality in chronic graft versus host disease. Journal of the European Academy of Dermatology and Venereology 1996;7:155-62.
Besnier 1997 {published data only}
  • Besnier DP, Chabannes D, Mahe B, Mussini JM, Baranger TA, Muller JY, et al. Treatment of graft-versus-host disease by extracorporeal photochemotherapy: a pilot study. Transplantation 1997;64(1):49-54.
Biagi 2000 {published data only}
  • Biagi E, Perseghin P, Buscemi F, Dassi M, Rovelli A, Balduzzi A. Effectiveness of extracorporeal photochemotherapy in treating refractory chronic graft-versus-host disease. Haematologica 2000;85(3):329-30.
Bisaccia 2011 {published data only}
  • Bisaccia E, Palangio M, Gonzalez J. Long-term extracorporeal photochemotherapy in a pediatric patient with refractory sclerodermatous chronic graft-versus-host disease. Transfusion and Apheresis Science 2011;45(2):187-90.
Child 1999 {published data only}
  • Child FJ, Ratnavel R, Watkins P, Samson D, Apperley J, Ball J, et al. Extracorporeal photopheresis (ECP) in the treatment of chronic graft-versus-host disease (GVHD). Bone Marrow Transplantation 1999;23(9):881-7.
D'Incan 2000 {published data only}
  • D'Incan M, Kanold J, Halle P, De Lumley L, Souteyrand P, Demeocq F. Extracorporeal photopheresis as an alternative therapy for drug-resistant graft versus host disease: three cases. Annales de Dermatologie et de Venereologie 2000;127(2):166-70.
Dall'Amico 1997 {published data only}
Flowers 2008 {published data only}
  • Flowers ME, Apperley JF, van Besien K, Elmaagacli A, Grigg A, Reddy V, et al. A multicenter prospective phase 2 randomized study of extracorporeal photopheresis for treatment of chronic graft-versus-host disease. Blood. 2008;112(7):2667-74.
Foss 2003 {published data only}
  • Foss FM. Extracorporeal photopheresis in the treatment of graft-vs-host disease. Journal of Cutaneous Medicine and Surgery 2003;7(4 Suppl):13-7.
Foss 2005 {published data only}
  • Foss FM, DiVenuti GM, Chin K, Sprague K, Grodman H, Klein A, et al. Prospective study of extracorporeal photopheresis in steroid-refractory or steroid-resistant extensive chronic graft-versus-host disease: analysis of response and survival incorporating prognostic factors. Bone Marrow Transplantation 2005;35(12):1187-93.
Halle 2002 {published data only}
  • Halle P, Paillard C, D'Incan M, Bordigoni P, Piguet C, De Lumley L, et al. Successful extracorporeal photochemotherapy for chronic graft-versus-host disease in pediatric patients. Journal of Hematotherapy & Stem Cell Research 2002;11(3):501-12.
Kanold 2003 {published data only}
  • Kanold J, Paillard C, Halle P, D'Incan M, Bordgoni P, Demeocq F. Extracorporeal photochemotherapy for graft versus host disease in pediatric patients. Transfusion and Apheresis Science: official journal of the World Apheresis Association: official journal of the European Society for Haemapheresis 2003;28(1):71-80.
Kanold 2005 {published data only}
  • Kanold J, Messina C, Halle P, Locatelli F, Lanino E, Cesaro S, et al. Update on extracorporeal photochemotherapy for graft-versus-host disease treatment. Bone Marrow Transplantation 2005;35(Suppl 1):S69-71.
Looks 1997 {published data only}
  • Looks A, Fuchs D, Rulke D, Lane D, Zintl F, Wollina U. Successful treatment of acute graft versus host disease after bone marrow transplantation in 16-year old girl with extracorporeal photopheresis. Onkologie 1997;20:340-2.
Messina 2003 {published data only}
Perotti 1999 {published data only}
  • Perotti C, Torretta L, Viarengo G, Roveda L, Bernuzzi S, Carbone S, et al. Feasibility and safety of a new technique of extracorporeal photochemotherapy: experience of 240 procedures. Haematologica 1999;84(3):237-41.
Peters 2000 {published data only}
  • Peters C, Minkov M, Gadner H, Klingebiel T, Vossen J, Locatelli F, et al. Statement of current majority practices in graft-versus-host disease prophylaxis and treatment in children. Bone Marrow Transplantation 2000;26(4):405-11.
Rossetti 1995 {published data only}
  • Rossetti F, Zulian F, Dall'Amico R, Messina C, Montini G, Zacchello F. Extracorporeal photochemotherapy as single therapy for extensive, cutaneous, chronic graft-versus-host disease. Transplantation. 1995;59(1):149-51.
Rossetti 1996 {published data only}
  • Rossetti F, Dall'Amico R, Crovetti G, Messina C, Montini G, Dini G, et al. Extracorporeal photochemotherapy for the treatment of graft-versus-host disease. Bone Marrow Transplantation 1996;18(Suppl 2):175-81.
Salvaneschi 2001 {published data only}
Zecca 2000 {published data only}
  • Zecca M, Locatelli F. Management of graft-versus-host disease in paediatric bone marrow transplant recipients. Paediatric Drugs 2000;2(1):29-55.

References to ongoing studies

  1. References to studies excluded from this review
  2. References to ongoing studies
  3. Additional references
NCT 00609609 {unpublished data only}
  • A Randomized Phase II Study for the Evaluation of Extracorporeal Photopheresis (ECP) in Combination with Corticosteroids for the Initial Treatment of Acute Graft-Versus-Host Disease (GvHD). Ongoing study January 2008 to January 2015.

Additional references

  1. References to studies excluded from this review
  2. References to ongoing studies
  3. Additional references
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Fimiani 2004
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Girardi 2002
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Kjaergard 2001
Lamioni 2005
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Legitimo 2007
Locatelli 2000
Maeda 2005
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Peters 2003
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