Intervention Protocol

Closure versus medical therapy for preventing recurrent stroke in patients with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

  1. Jie Li,
  2. Ming Liu*,
  3. Shihong Zhang,
  4. Zilong Hao,
  5. Canfei Zhang,
  6. Jing Zhang

Editorial Group: Cochrane Stroke Group

Published Online: 11 JUL 2012

Assessed as up-to-date: 29 NOV 2011

DOI: 10.1002/14651858.CD009938

How to Cite

Li J, Liu M, Zhang S, Hao Z, Zhang C, Zhang J. Closure versus medical therapy for preventing recurrent stroke in patients with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack (Protocol). Cochrane Database of Systematic Reviews 2012, Issue 7. Art. No.: CD009938. DOI: 10.1002/14651858.CD009938.

Author Information

  1. West China Hospital, Sichuan University, Department of Neurology, Chengdu, Sichuan, China

*Ming Liu, Department of Neurology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, Sichuan, 610041, China. wyplmh@hotmail.com.

Publication History

  1. Publication Status: New
  2. Published Online: 11 JUL 2012

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

The first objective is to compare the safety and efficacy of transcatheter device closure (TDC) with best medical therapy alone for the prevention of recurrent stroke (fatal or not) or TIA in patients with PFO and a history of cryptogenic stroke or TIA. The second objective is to identify specific subgroups of patients most likely to benefit from closure for secondary prevention and to assess the cost-effectiveness of this strategy, if possible.