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Closure versus medical therapy for preventing recurrent stroke in patients with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

  • Protocol
  • Intervention

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Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

The first objective is to compare the safety and efficacy of transcatheter device closure (TDC) with best medical therapy alone for the prevention of recurrent stroke (fatal or not) or TIA in patients with PFO and a history of cryptogenic stroke or TIA. The second objective is to identify specific subgroups of patients most likely to benefit from closure for secondary prevention and to assess the cost-effectiveness of this strategy, if possible.

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