Intervention Review

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Pre-referral rectal artesunate for severe malaria

  1. Joseph Okebe1,*,
  2. Michael Eisenhut2

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 29 MAY 2014

Assessed as up-to-date: 21 MAY 2014

DOI: 10.1002/14651858.CD009964.pub2


How to Cite

Okebe J, Eisenhut M. Pre-referral rectal artesunate for severe malaria. Cochrane Database of Systematic Reviews 2014, Issue 5. Art. No.: CD009964. DOI: 10.1002/14651858.CD009964.pub2.

Author Information

  1. 1

    Medical Research Council Unit, Banjul, Gambia

  2. 2

    Luton & Dunstable University Hospital NHS Foundation Trust, Paediatric Department, Luton, UK

*Joseph Okebe, Medical Research Council Unit, P.O. Box 273, Banjul, Gambia. jokebe@mrc.gm.

Publication History

  1. Publication Status: New
  2. Published Online: 29 MAY 2014

SEARCH

[Figure 1]
Figure 1. Risk of bias summary: review authors' judgements about each risk of bias item for the included trial.
[Figure 2]
Figure 2. Search results and article selection.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Pre-referral artesunate vs Placebo, Outcome 1 All cause mortality (all enrolled).
[Analysis 1.2]
Analysis 1.2. Comparison 1 Pre-referral artesunate vs Placebo, Outcome 2 All cause mortality (young children).
[Analysis 1.3]
Analysis 1.3. Comparison 1 Pre-referral artesunate vs Placebo, Outcome 3 All cause mortality (older children/adults).
[Analysis 1.4]
Analysis 1.4. Comparison 1 Pre-referral artesunate vs Placebo, Outcome 4 Neurodisability (all participants).
[Analysis 1.5]
Analysis 1.5. Comparison 1 Pre-referral artesunate vs Placebo, Outcome 5 Severe malaria on admission (coma, repeated convulsions or prostration).
[Analysis 1.6]
Analysis 1.6. Comparison 1 Pre-referral artesunate vs Placebo, Outcome 6 Proportion with parasitaemia on admission.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Pre-referral artesunate vs Placebo, Outcome 7 Proportion reaching a hospital within 6 hours.