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Pre-referral rectal artesunate for severe malaria

  1. Joseph Okebe1,*,
  2. Michael Eisenhut2

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 29 MAY 2014

Assessed as up-to-date: 21 MAY 2014

DOI: 10.1002/14651858.CD009964.pub2


How to Cite

Okebe J, Eisenhut M. Pre-referral rectal artesunate for severe malaria. Cochrane Database of Systematic Reviews 2014, Issue 5. Art. No.: CD009964. DOI: 10.1002/14651858.CD009964.pub2.

Author Information

  1. 1

    Medical Research Council Unit, Banjul, Gambia

  2. 2

    Luton & Dunstable University Hospital NHS Foundation Trust, Paediatric Department, Luton, UK

*Joseph Okebe, Medical Research Council Unit, P.O. Box 273, Banjul, Gambia. jokebe@mrc.gm.

Publication History

  1. Publication Status: New
  2. Published Online: 29 MAY 2014

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Gomes 2009 {published data only}
  • Gomes MF, Faiz MA, Gyapong JO, Warsame M, Agbenyega T, Babiker A, et al. Pre-referral rectal artesunate to prevent death and disability in severe malaria: a placebo-controlled trial. Lancet 2009;373:557-66.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Aceng 2005 {published data only}
  • Aceng JR, Byarugaba JS, Tumwine JK. Rectal artemether versus intravenous quinine for the treatment of cerebral malaria in children in Uganda: randomised clinical trial. British Medical Journal (Clinical Research ed.) 2005;330(7487):334.
Barnes 2004 {published data only}
  • Early rectal artesunate is more effective at reducing parasite density compared with intramuscular quinine in people with moderately severe malaria. Evidence-Based Healthcare and Public Health. Vol. 8, 2004:375-6.
  • Barnes KI, Mwenechanya J, Tembo M, McIlleron H, Folb PI, Ribeiro I, et al. Efficacy of rectal artesunate compared with parenteral quinine in initial treatment of moderately severe malaria in African children and adults: a randomised study. Lancet 2004;363(9421):1598-605.
Gomes 2010 {published data only}
  • Gomes MF, Warsame M, Nasemba N, Singlovic J, Kapinga A, Mwankuyse S, et al. Gaining time: early treatment of severe pediatric malaria in Tanzania. Drug Development Research 2010;71(1):92-8.
Karunajeewa 2006 {published data only}
  • Karunajeewa HA, Reeder J, Lorry K, Dabod E, Hamzah J, Page-Sharp M, et al. Artesunate suppositories versus intramuscular artemether for treatment of severe malaria in children in Papua New Guinea. Antimicrobial Agents and Chemotherapy 2006;50(3):968-74.
Kitua 2010 {published data only}
  • Kitua A, Folb P, Warsame M, Binka F, Faiz A, Ribeiro I, et al. The use of placebo in a trial of rectal artesunate as initial treatment for severe malaria patients en route to referral clinics: ethical issues. Journal of Medical Ethics 2010;36(2):116-20.
Krishna 2001 {published data only}
  • Krishna S, Planche T, Agbenyega T, Woodrow C, Agranoff D, Bedu-Addo G, et al. Bioavailability and preliminary clinical efficacy of intrarectal artesunate in Ghanaian children with moderate malaria. Antimicrobial Agents and Chemotherapy 2001;45(2):509-16.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Awad 2003
  • Awad MI, Alkadru AM, Behrens RH, Baraka OZ, Eltayeb IB. Descriptive study on the efficacy and safety of artesunate suppository in combination with other antimalarials in the treatment of severe malaria in Sudan. The American Journal of Tropical Medicine and Hygiene 2003;68(2):153-8.
Bello 2009
Dondorp 2005
Dondorp 2010
  • Dondorp AM, Fanello CI, Hendriksen IC, Gomes E, Seni A, Chhaganlal KD, et al. Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial. Lancet 2010;376:1647-57.
German 2008
Gomes 2008
  • Gomes M, Ribeiro I, Warsame M, Karunajeewa H, Petzold M. Rectal artemisinins for malaria: a review of efficacy and safety from individual patient data in clinical studies. BioMed Central Infectious Diseases 2008;8:39.
Gomes 2011
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Karunajeewa 2004
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