Intervention Review

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Non pharmacological interventions for spasticity in multiple sclerosis

  1. Bhasker Amatya1,*,
  2. Fary Khan1,2,3,
  3. Loredana La Mantia4,
  4. Marina Demetrios1,
  5. Derick T Wade5

Editorial Group: Cochrane Multiple Sclerosis and Rare Diseases of the Central Nervous System Group

Published Online: 28 FEB 2013

Assessed as up-to-date: 19 MAY 2012

DOI: 10.1002/14651858.CD009974.pub2


How to Cite

Amatya B, Khan F, La Mantia L, Demetrios M, Wade DT. Non pharmacological interventions for spasticity in multiple sclerosis. Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD009974. DOI: 10.1002/14651858.CD009974.pub2.

Author Information

  1. 1

    Royal Melbourne Hospital, Royal Park Campus, Department of Rehabilitation Medicine, Melbourne, Victoria, Australia

  2. 2

    Monash University, School of Public Health and Preventive Medicine, Melbourne, Victoria, Australia

  3. 3

    University of Melbourne, Department of Medicine, Dentistry & Health Sciences, Melbourne, Victoria, Australia

  4. 4

    I.R.C.C.S. Santa Maria Nascente Fondazione Don Gnocchi, Unit of Neurology - Multiple Sclerosis Center, Milano, Italy

  5. 5

    University of Oxford, Oxford Centre for Enablement, Oxford, UK

*Bhasker Amatya, Department of Rehabilitation Medicine, Royal Melbourne Hospital, Royal Park Campus, Poplar Road, Parkville, Melbourne, Victoria, 3052, Australia. Bhasker.Amatya@mh.org.au.

Publication History

  1. Publication Status: New
  2. Published Online: 28 FEB 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Giovannelli 2007 {published data only}
  • Giovannelli M, Borriello G, Castri P, Prosperini L, Pozzilli C. Early physiotherapy after injection of botulinum toxin increases the beneficial effects on spasticity in patients with multiple sclerosis. Clinical Rehabilitation 2007;21(4):331-7.
Lappin 2003 {published data only}
  • Lappin MS, Lawrie FW, Richards TL, Kramer ED. Effects of a pulsed electromagnetic therapy on multiple sclerosis fatigue and quality of life: a double-blind, placebo controlled trial. Alternative Therapies in Health and Medicine 2003;9:38-48.
Miller 2007 {published data only}
  • Miller L, Mattison P, Paul L, Wood L. The effects of Transcutaneous Electrical Nerve Stimulation (TENS) on spasticity in Multiple Sclerosis. Multiple Sclerosis 2007;13:527-33.
Mori 2010 {published data only}
Mori 2011 {published data only}
  • Mori F, Ljoka C, Magni E, Codeca C, Kusayanagi H, Monteleone F, et al. Transcranial magnetic stimulation primes the effects of exercise therapy in multiple sclerosis. Journal of Neurology 2011;258(7):1281-7.
Nielsen 1996 {published data only}
  • Nielsen JF, Sinkjaer T, Jakobsen J. Treatment of spasticity with repetitive magnetic stimulation; a double-blind placebo-controlled study. Multiple Sclerosis 1996;2(5):227-32.
Richards 1997 {published data only}
  • Richards TL, Lappin MS, Acosta-Urquidi J, Kraft GH, Heide AC, Lawrie FW, et al. Double-blind study of pulsing magnetic field effects on multiple sclerosis. Journal of Alternative & Complementary Medicine 1997;3(1):21-9.
Schyns 2009 {published data only}
  • Schyns F, Paul L, Finlay K, Ferguson C, Noble E. Vibration therapy in multiple sclerosis: a pilot study exploring its effects on tone, muscle force, sensation and functional performance. Clinical Rehabilitation 2009;23(9):771-81.
Velkonja 2010 {published data only}
  • Velikonja O, Curic K, Ozura A, Jazbec SS. Influence of sports climbing and yoga on spasticity, cognitive function, mood and fatigue in patients with multiple sclerosis. Clinical Neurology & Neurosurgery 2010;112(7):597-601.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Bernhardt 2011 {published data only}
  • Bernhardt L, Marziniak M. Specific resistance training for patients with multiple sclerosis. Multiple Sclerosis 2011;17:S465.
Castro-Sanchez 2012 {published data only}
  • Castro-Sanchez AM, Mataran-Penarrocha GA, Lara-Palomo I, Saavedra-Hernandez M, Arroyo-Morales M, Moreno-Lorenzo C. Hydrotherapy for the treatment of pain in people with Multiple Sclerosis: a randomized controlled trial.. Evidence-Based Complementary and Alternatative Medicine 2012;[Epub ahead of print]:DOI: 10.1155/2012/473963.
Chiara 1998 {published data only}
  • Chiara T, Carlos J Jr, Martin D, Miller R, Nadeau S. Cold effect on oxygen uptake, perceived exertion, and spasticity in patients with Multiple Sclerosis. Archives of Physical Medicine & Rehabilitation 1998;79:523-8.
Farenelli 1999 {published data only}
  • Farinelli M, Baratto L, Betti E, Morasso P Capra R, Spada G. Acupuncture improves postural control in patients with lower limbs spasticity: a randomized controlled trial. Giornale Italiano di Riflessoterapia ed Agopuntura 1999;11:71-4.
Huges 2009 {published data only}
  • Hughes CM, Smyth S, Lowe-Strong AS. Reflexology for the treatment of pain in people with multiple sclerosis: a double-blind randomised sham-controlled clinical trial. Multiple Sclerosis 2009;15:1329-38.
Leocani 2012 {published data only}
  • Leocani L, Nuara A, Formenti A, Rossi P, Zangen A, Comola M, et al. Deep rTMS with H-Coil associated with rehabilitation enhances improvement of walking abilities in patients with progressive multiple sclerosis: randomized, controlled, double blind study. Neurology 2012;259(Suppl 1):S1–S236.
Livesley 1992 {published data only}
  • Livesley E. Effects of electrical neuromuscular stimulation on functional performance in patients with Multiple Sclerosis. Physiotherapy 1992;78:914-7.
Shaygannejad 2011 {published data only}
  • Shaygannejad V, Ashtari F, Haghighi S, Vaezi A. The effect of Transcutaneous Electrical Nerve Stimulations on spasticity in Multiple Sclerosis patients in comparison with baclofen: a randomised single-blinded clinical trial. Multiple Sclerosis 2011;17:S246.
Sosnoff 2009 {published data only}
  • Sosnoff J, Motl RW, Snook EM, Wynn D. Effect of a 4-week period of unloaded leg cycling exercise on spasticity in multiple sclerosis. Neurorehabilitation 2009;24:327-31.
Szecsi 2009 {published data only}
  • Szecsi J, Schlick C, Schiller M, Pollmann W, Koenig N, Straube A. Functional electrical stimulation-assisted cycling of patients with Multiple Sclerosis: biomechanical and functional outcome - a pilot study. Journal of Rehabilitation Medicine 2009;41:674-80.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Ansari 2008
  • Ansari NN, Naghdi S, Hasson S, Azarsa MH, Azarnia S. The Modified Tardieu Scale for the measurement of elbow flexor spasticity in adult patients with hemiplegia. Brain Injury 2008;22(13-14):1007-12.
Ansari 2009
  • Ansari NN, Naghdi S, Hasson S, Fakhari Z, Mashayekhi M, Herasi M. Assessing the reliability of the Modified Modified Ashworth Scale between two physiotherapists in adult patients with hemiplegia. NeuroRehabilitation 2009;25(4):235-40.
Ashford 2010
  • Ashford S, Turner-Stokes L, Nair A. Poster 19: Psychometric evaluation of the Arm Activity Measure (ArmA) – A measure of active and passive function in the hemiparetic arm. Physical Medicine and Rehabilitation 2010;2(9 Suppl):S13-4.
Ashworth 1964
Beard 2003
  • Beard S, Hunn A, Wight J. Treatments for spasticity and pain in multiple sclerosis: a systematic review. Health Technology Assessment 2003;7:1-111.
Bhakta 1996
Bohannon 1987
Brashear 2002
  • Brashear A, Gordon M, Elovic E, Kassicieh D, Marciniak C, Lee C, et al. Intramuscular injection of botulinum toxin for the treatment of wrist and finger spasticity after stroke. New England Journal of Medicine 2002;347(6):395-400.
Buetefisch 1995
  • Buetefisch C, Hummelsheim H, Denzler P, Mauritz KH. Repetitive training of isolated movements improves the outcome of motor rehabilitation of the centrally paretic hand. Journal of Neurological Sciences 1995;130:59–68.
De Paiva 1999
  • De Paiva A, Meuniere FA, Molgo J, Aoki KR, Dolly JO. Functional repair of motor endplates after botulinum neurotoxin type A poisoning: biphasic switch of synaptic activity between nerve sprouts and their parent terminals. Proceedings of the National Academy of Sciences, United States of America. 1999; Vol. 16, issue 96:3200-5.
Demetrios 2012
  • Demetrios M, Turner-Stokes L, Brand C, McSweeney S, Khan F. Multidisciplinary rehabilitation following botulinum toxin and other focal intramuscular treatment for post-stroke spasticity. Cochrane Database of Systematic Reviews 2012, Issue 3. [DOI: 10.1002/14651858.CD009689]
Egger 1998
Goetzsche 1987
  • Goetzsche PC. Reference bias in reports of drug trials. British Medical Journal 1987;295:654-6.
Green 2002
Harned 2011
  • Harned ME, Salles SS, Grider JS. An introduction to trialing intrathecal baclofen in patients with hemiparetic spasticity: a description of 3 cases. Pain Physician 2011;14(5):483-9.
Haselkorn 2005
  • Haselkorn Jk, Little JW, Balsdon Richer CB, Miller JR, Fry-Welch D, Herndon RM, et al. Spasticity management in Multiple Sclerosis. Journal of Spinal Cord Medicine 2005;28(2):167-99.
Henze 2006
  • Henze T, Rieckmann P, Toyka KV. Symptomatic treatment of multiple sclerosis (Multiple Sclerosis Therapy Consensus Group (MSTCG) of the German Multiple Sclerosis Society). European Neurology 2006;56:78–105.
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from: www.cochrane-handbook.org.
Hobart 2006
  • Hobart JC, Riazi A, Thompson AJ, Styles IM, Ingram W, Vickery PJ, et al. Getting the measure of spasticity in multiple sclerosis: The Multiple Sclerosis Spasticity Scale (MSSS-88). Brain 2006;129:224-34.
Kesiktas 2004
Khan 2007
  • Khan F, Turner-Stokes L, Ng L, Kilpatrick T, Amatya B. Multidisciplinary rehabilitation for adults with multiple sclerosis. Cochrane Database of Systematic Reviews 2007, Issue 2. [DOI: 10.1002/14651858.CD006036]
Khan 2010
  • Khan F, Gray O. Disability management and rehabilitation for persons with multiple sclerosis. Neural Regeneration Research 2010;5(4):301-9.
Kurtzke 1983
Lance 1980
  • Lance JW. Spasticity: disordered motor control. In: Feldman RG, Young RR, Koella WP editor(s). Symposium Synopsis. Chicago: Year Book Medical Publishers, 1980:485-94.
Langhorne 2011
Lockley 2006
  • Lockley LJ, Buchanan K. Physical management of spasticity. In: Stevenson VL, Jarrett L editor(s). Spasticity Management: a Practical Multidisciplinary Guide. London: Informa Healthcare, 2006:37-58.
Lublin 1996
  • Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 1996;46(4):907-11.
Lyle 1981
Mahoney 1965
  • Mahoney FI, Barthel D. Functional evaluation: the Barthel Index. Maryland State Medical Journal 1965;14:56-61.
Mc Donald 2001
Mecomber 1971
  • Mecomber SA, Herman RM. Effects of local hypothermia on reflex and voluntary activity. Physical Therapy 1971;51(3):271-81.
Mehrholz 2005
  • Mehrholz J, Wagner K, Meissner D, Grundmann K, Zange C, Koch R, et al. Reliability of the Modified Tardieu Scale and the Modified Ashworth Scale in adult patients with severe brain injury: a comparison study. Clinical Rehabilitation 2005;19:751-9.
Monaghan 2011
  • Monaghan K, Horgan F, Blake C, Cornall C, Hickey PPM, Lyons BE, et al. Physical treatment interventions for managing spasticity after stroke. Cochrane Database of Systematic Reviews 2011, Issue 7. [DOI: 10.1002/14651858.CD009188]
MS Australia 2009
  • MS Australia. Spasticity and multiple sclerosis. MS Practice: June 2009; Vol. ISBN: 978-0-9806637-4-7.
Mukherjee 2010
  • Mukherjee A, Chakravarty A. Spasticity mechanisms – for the clinician. Frontiers in Neurology 2010;149:1-9.
O'Dwyer 1996
Pandyan 2005
  • Pandyan AD, Gregoric M, Barnes MP, Wood D, Van Wijck F, Burridge J, et al. Spasticity: clinical perceptions, neurological realities and meaningful measurement. Disability and Rehabilitation 2005;27(1-2):2-6.
Penn 1989
Pfleger 2010
  • Pfleger CC, Flachs EM, Koch-Henriksen N. Social consequences of multiple sclerosis (1): early pension and temporary unemployment--a historical prospective cohort study. Multiple Sclerosis 2010;16:121-6.
Pfleger 2010a
  • Pfleger CC, Flachs EM, Koch-Henriksen N. Social consequences of multiple sclerosis. Part 2. Divorce and separation: a historical prospective cohort study. Multiple Sclerosis 2010;16:878-82.
Podsiadlo 1991
  • Podsiadlo D, Richardson S. The timed 'up and go': a test of basic functional mobility for frail elderly persons. Journal of the American Geriatrics Society 1991;39:142-8.
Polman 2005
Poser 1993
Rekand 2010
RevMan 2011
  • The Nordic Cochrane Centre,The Cochrane Collaboration. Review Manager (RevMan). 5.1. Copenhagen: The Nordic Cochrane Centre,The Cochrane Collaboration, 2011.
Rietberg 2007
Rizzo 2004
Robinson 1983
Shakespeare 2003
  • Shakespeare D, Boggild M, Young CA. Anti-spasticity agents for multiple sclerosis. Cochrane Database of Systematic Reviews 2003, Issue 4. [DOI: 10.1002/14651858.CD001332]
Sheean 1998
  • Sheean G. Pathophysiology of spasticity. In: Sheean G editor(s). Spasticity Rehabilitation. First Edition. London: Churchill Communications Europe LTD, 1998:17-38.
Steins 2002
  • Steins S, O'Young B, Young M. Person-centred rehabilitation: interdisciplinary intervention to enhance patient enablement. In: O'Young B, Young M, Steins S editor(s). Physical Medicine and Rehabilitation Secrets. United States of America: Hanley & Belfus, 2002:4-9.
Stevenson 2010
Turner-Stokes 2011
Van der Lee 2004
van Tulder 1997
  • van Tulder MW, Assendelft WJ, Koes BW, Bouter LM. Method guidelines for systematic reviews in the Cochrane Collaborations Back Review Group for Spinal Disorders. Spine 1997;22:2323-30.
Van Tulder 2003
Vickrey 1997
  • Vickrey BG, Hays RD, Genovese BJ, Myers LW, Ellison GW. Comparison of a generic to disease-targeted health-related quality-of-life measures for multiple sclerosis. Journal of Clinical Epidemiology 1997;50(5):557-69.
Wade 2010
Weinshenker 1989
  • Weinshenker BG, Bass B, Rice GP, Noseworthy J, Carriere W, Baskerville J, et al. The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability. Brain 1989;112:133-46.
WHO 2001
  • World Health Organization. International Classification of Functioning Disability and Health (ICF). Geneva: WHO 2001.
WHO 2004
  • World Health Organization. Atlas: country resources for neurological disorders. Programme for Neurological Diseases and Neuroscience, Geneva 2004.