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Intermittent oral iron supplementation during pregnancy

  1. Juan Pablo Peña-Rosas1,*,
  2. Luz Maria De-Regil1,
  3. Therese Dowswell2,
  4. Fernando E Viteri3

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 11 JUL 2012

Assessed as up-to-date: 12 JUN 2012

DOI: 10.1002/14651858.CD009997


How to Cite

Peña-Rosas JP, De-Regil LM, Dowswell T, Viteri FE. Intermittent oral iron supplementation during pregnancy. Cochrane Database of Systematic Reviews 2012, Issue 7. Art. No.: CD009997. DOI: 10.1002/14651858.CD009997.

Author Information

  1. 1

    World Health Organization, Evidence and Programme Guidance, Department of Nutrition for Health and Development, Geneva, Switzerland

  2. 2

    The University of Liverpool, Cochrane Pregnancy and Childbirth Group, Department of Women's and Children's Health, Liverpool, UK

  3. 3

    Children's Hospital and Oakland Research Institute, Oakland, CA, USA

*Juan Pablo Peña-Rosas, Evidence and Programme Guidance, Department of Nutrition for Health and Development, World Health Organization, 20 Avenue Appia, Geneva, 1211, Switzerland. penarosasj@who.int.

Publication History

  1. Publication Status: New
  2. Published Online: 11 JUL 2012

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[Figure 1]
Figure 1. Study flow diagram.
[Figure 2]
Figure 2. 'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 3]
Figure 3. 'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 1 Low birthweight (less than 2500 g) (ALL).
[Analysis 2.2]
Analysis 2.2. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 2 Low birthweight (less than 2500 g) SUBGROUP ANALYSIS by weekly dose of iron.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 3 Low birthweight (less than 2500 g) SUBGROUP ANALYSIS by anaemia status.
[Analysis 2.4]
Analysis 2.4. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 4 Low birthweight (less than 2500 g) SUBGROUP ANALYSIS by gestational age.
[Analysis 2.5]
Analysis 2.5. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 5 Low birthweight (less than 2500 g) SUBGROUP ANALYSIS by intermittent regimen.
[Analysis 2.6]
Analysis 2.6. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 6 Birthweight (g) (ALL).
[Analysis 2.7]
Analysis 2.7. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 7 Birthweight (g) SUBGROUP ANALYSIS by gestational age.
[Analysis 2.8]
Analysis 2.8. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 8 Birthweight (g) SUBGROUP ANALYSIS by anaemia status.
[Analysis 2.9]
Analysis 2.9. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 9 Birthweight (g) SUBGROUP ANALYSIS by weekly dose of iron.
[Analysis 2.10]
Analysis 2.10. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 10 Birthweight (g) SUBGROUP ANALYSIS by intermittent regimen.
[Analysis 2.11]
Analysis 2.11. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 11 Premature birth (less than 37 weeks of gestation) (ALL).
[Analysis 2.12]
Analysis 2.12. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 12 Premature birth (less than 37 weeks' gestation) SUBGROUP ANALYSIS by gestational age.
[Analysis 2.13]
Analysis 2.13. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 13 Premature birth (less than 37 weeks' gestation) SUBGROUP ANALYSIS by anaemia status.
[Analysis 2.14]
Analysis 2.14. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 14 Premature birth (less than 37 weeks' gestation) SUBGROUP ANALYSIS by weekly dose of iron.
[Analysis 2.15]
Analysis 2.15. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 15 Premature birth (less than 37 weeks' gestation) SUBGROUP ANALYSIS by intermittent regimen.
[Analysis 2.18]
Analysis 2.18. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 18 Maternal anaemia at term (Hb less than 110 g/L at 37 weeks' gestation or more) (ALL).
[Analysis 2.19]
Analysis 2.19. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 19 Maternal anaemia at term (Hb less than 110 g/L at 37 weeks' gestation or more) SUBGROUP ANALYSIS by gestational age.
[Analysis 2.20]
Analysis 2.20. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 20 Maternal anaemia at term (Hb less than 110 g/L at 37 weeks' gestation or more) SUBGROUP ANALYSIS by anaemia status.
[Analysis 2.21]
Analysis 2.21. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 21 Maternal anaemia at term (Hb less than 110 g/L at 37 weeks' gestation or more) SUBGROUP ANALYSIS by weekly dose of iron.
[Analysis 2.22]
Analysis 2.22. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 22 Maternal anaemia at term (Hb less than 110 g/L at 37 weeks' gestation or more) SUBGROUP ANALYSIS by intermittent regimen.
[Analysis 2.24]
Analysis 2.24. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 24 Maternal iron deficiency anaemia at term (Hb less than 110 g/L and at least one additional laboratory indicators at 37 weeks gestation or more) (ALL).
[Analysis 2.26]
Analysis 2.26. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 26 Side effects (any reported throughout intervention period) (ALL).
[Analysis 2.27]
Analysis 2.27. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 27 Side effects (any reported throughout intervention period) SUBGROUP ANALYSIS by gestational age.
[Analysis 2.28]
Analysis 2.28. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 28 Side effects (any reported throughout intervention period) SUBGROUP ANALYSIS by anaemia status.
[Analysis 2.29]
Analysis 2.29. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 29 Side effects (any reported throughout intervention period)SUBGROUP ANALYSIS by weekly dose of iron.
[Analysis 2.30]
Analysis 2.30. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 30 Side effects (any reported throughout intervention period) SUBGROUP ANALYSIS by intermittent regimen.
[Analysis 2.31]
Analysis 2.31. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 31 Severe anaemia at any time during second and third trimester (Hb less than 70 g/L) (ALL).
[Analysis 2.32]
Analysis 2.32. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 32 Severe anaemia at any time during the 2nd and 3rd trimesters SUBGROUP ANALYSIS by gestational age.
[Analysis 2.33]
Analysis 2.33. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 33 Severe anaemia at any time during the 2nd and 3rd trimesters SUBGROUP ANALYSIS by anaemia status.
[Analysis 2.34]
Analysis 2.34. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 34 Severe anaemia at any time during the 2nd and 3rd trimesters SUBGROUP ANALYSIS by weekly dose of iron.
[Analysis 2.35]
Analysis 2.35. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 35 Severe anaemia at any time during the 2nd and 3rd trimesters SUBGROUP ANALYSIS by intermittent regimen.
[Analysis 2.38]
Analysis 2.38. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 38 Very low birthweight (less than 1500 g) (ALL).
[Analysis 2.39]
Analysis 2.39. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 39 Very premature birth (less than 34 weeks of gestation) (ALL).
[Analysis 2.40]
Analysis 2.40. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 40 Infant ferritin concentration in the first 6 months (μg/L, counting the last reported measure after birth within this period) (ALL).
[Analysis 2.41]
Analysis 2.41. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 41 Maternal anaemia at or near term (Hb less than 110 g/L at 34 weeks gestation or more) (ALL).
[Analysis 2.42]
Analysis 2.42. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 42 Maternal iron deficiency at or near term (based on any indicator of iron status at 34 weeks' gestation or more) (ALL).
[Analysis 2.43]
Analysis 2.43. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 43 Maternal iron deficiency anaemia at or near term (Hb less than 110 g/L and at least one additional laboratory indicators at 34 weeks gestation or more) (ALL).
[Analysis 2.44]
Analysis 2.44. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 44 Maternal haemoglobin concentration at or near term (in g/L at 34 weeks' gestation or more) (ALL).
[Analysis 2.45]
Analysis 2.45. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 45 Maternal high haemoglobin concentrations during second or third trimester (Hb more than 130 g/L) (ALL).
[Analysis 2.46]
Analysis 2.46. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 46 Moderate anaemia at any time during second or third trimester (Hb between 70 and 99 g/L)(ALL).
[Analysis 2.47]
Analysis 2.47. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 47 Severe anaemia at term (Hb less than 70 g/L at 37 weeks' gestation or more) (ALL).
[Analysis 2.48]
Analysis 2.48. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 48 Severe anaemia at or near term (Hb less than 70 g/L at 34 weeks' gestation or more) (ALL).
[Analysis 2.49]
Analysis 2.49. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 49 Severe anaemia at postpartum (Hb less than 80 g/L) (ALL).
[Analysis 2.50]
Analysis 2.50. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 50 Antepartum haemorrhage (ALL).
[Analysis 2.51]
Analysis 2.51. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 51 Diarrhoea (ALL).
[Analysis 2.52]
Analysis 2.52. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 52 Constipation (ALL).
[Analysis 2.53]
Analysis 2.53. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 53 Nausea (ALL).
[Analysis 2.54]
Analysis 2.54. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 54 Heartburn (ALL).
[Analysis 2.55]
Analysis 2.55. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 55 Vomiting (ALL).
[Analysis 2.56]
Analysis 2.56. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 56 Placental abruption (ALL).
[Analysis 2.57]
Analysis 2.57. Comparison 2 Any intermittent iron regimen (with or without other vitamins and minerals) compared with daily regimen (with same vitamins and minerals), Outcome 57 Premature rupture of membranes (ALL).
[Analysis 6.1]
Analysis 6.1. Comparison 6 Intermittent oral iron alone supplementation versus daily iron alone supplementation, Outcome 1 Low birthweight (less than 2500 g) (ALL).
[Analysis 6.2]
Analysis 6.2. Comparison 6 Intermittent oral iron alone supplementation versus daily iron alone supplementation, Outcome 2 Birthweight (g) (ALL).
[Analysis 6.3]
Analysis 6.3. Comparison 6 Intermittent oral iron alone supplementation versus daily iron alone supplementation, Outcome 3 Premature birth (less than 37 weeks of gestation) (ALL).
[Analysis 6.6]
Analysis 6.6. Comparison 6 Intermittent oral iron alone supplementation versus daily iron alone supplementation, Outcome 6 Maternal anaemia at term (Hb less than 110 g/L at 37 weeks' gestation or more) (ALL).
[Analysis 6.10]
Analysis 6.10. Comparison 6 Intermittent oral iron alone supplementation versus daily iron alone supplementation, Outcome 10 Side effects (any reported throughout intervention period) (ALL).
[Analysis 6.11]
Analysis 6.11. Comparison 6 Intermittent oral iron alone supplementation versus daily iron alone supplementation, Outcome 11 Maternal severe anaemia at any time during second and third trimester (Hb less than 70 g/L) (ALL).
[Analysis 6.14]
Analysis 6.14. Comparison 6 Intermittent oral iron alone supplementation versus daily iron alone supplementation, Outcome 14 Maternal anaemia at or near term (Hb less than 110 g/L at 34 weeks gestation or more) (ALL).
[Analysis 6.15]
Analysis 6.15. Comparison 6 Intermittent oral iron alone supplementation versus daily iron alone supplementation, Outcome 15 Maternal haemoglobin concentration at or near term (in g/L at 34 weeks' gestation or more) (ALL).
[Analysis 6.16]
Analysis 6.16. Comparison 6 Intermittent oral iron alone supplementation versus daily iron alone supplementation, Outcome 16 Maternal high haemoglobin concentrations during second or third trimester (Hb more than 130 g/L) (ALL).
[Analysis 7.1]
Analysis 7.1. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 1 Low birthweight (less than 2500 g) (ALL).
[Analysis 7.2]
Analysis 7.2. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 2 Low birthweight (less than 2500 g) SUBGROUP ANALYSIS by gestational age.
[Analysis 7.3]
Analysis 7.3. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 3 Low birthweight (less than 2500 g) SUBGROUP ANALYSIS by anaemia status.
[Analysis 7.4]
Analysis 7.4. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 4 Low birthweight (less than 2500 g) SUBGROUP ANALYSIS by weekly dose of iron.
[Analysis 7.5]
Analysis 7.5. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 5 Low birthweight (less than 2500 g) SUBGROUP ANALYSIS by intermittent regimen.
[Analysis 7.6]
Analysis 7.6. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 6 Birthweight (g) (ALL).
[Analysis 7.7]
Analysis 7.7. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 7 Birthweight (g) SUBGROUP ANALYSIS by gestational age.
[Analysis 7.8]
Analysis 7.8. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 8 Birthweight (g) SUBGROUP ANALYSIS by anaemia status.
[Analysis 7.9]
Analysis 7.9. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 9 Birthweight (g) SUBGROUP ANALYSIS by weekly dose of iron.
[Analysis 7.10]
Analysis 7.10. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 10 Birthweight (g) SUBGROUP ANALYSIS by intermittent regimen.
[Analysis 7.11]
Analysis 7.11. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 11 Premature birth (less than 37 weeks of gestation) (ALL).
[Analysis 7.14]
Analysis 7.14. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 14 Maternal anaemia at term (Hb less than 110 g/L at 37 weeks' gestation or more) (ALL).
[Analysis 7.15]
Analysis 7.15. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 15 Maternal anaemia at term (Hb less than 110 g/L at 37 weeks' gestation or more) SUBGROUP ANALYSIS by gestational age.
[Analysis 7.16]
Analysis 7.16. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 16 Maternal anaemia at term (Hb less than 110 g/L at 37 weeks' gestation or more) SUBGROUP ANALYSIS by anaemia status.
[Analysis 7.17]
Analysis 7.17. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 17 Maternal anaemia at term (Hb less than 110 g/L at 37 weeks' gestation or more) SUBGROUP ANALYSIS by weekly dose of iron.
[Analysis 7.18]
Analysis 7.18. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 18 Maternal anaemia at term (Hb less than 110 g/L at 37 weeks' gestation or more) SUBGROUP ANALYSIS by intermittent regimen.
[Analysis 7.20]
Analysis 7.20. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 20 Maternal iron deficiency anaemia at term (Hb less than 110 g/L and at least one additional laboratory indicator at 37 weeks' gestation or more (ALL).
[Analysis 7.22]
Analysis 7.22. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 22 Side effects (any reported throughout intervention period) (ALL).
[Analysis 7.23]
Analysis 7.23. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 23 Side effects (any reported throughout intervention period) SUBGROUP ANALYSIS by gestational age.
[Analysis 7.24]
Analysis 7.24. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 24 Side effects (any reported throughout intervention period) SUBGROUP ANALYSIS by anaemia status.
[Analysis 7.25]
Analysis 7.25. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 25 Side effects (any reported throughout intervention period) SUBGROUP ANALYSIS by weekly dose of iron.
[Analysis 7.26]
Analysis 7.26. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 26 Side effects (any reported throughout intervention period) SUBGROUP ANALYSIS by intermittent regimen.
[Analysis 7.27]
Analysis 7.27. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 27 Severe anaemia at any time during second and third trimester (Hb less than 70 g/L) (ALL).
[Analysis 7.28]
Analysis 7.28. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 28 Severe anaemia at any time during the 2nd and 3rd trimesters (Hb less than 70 g/L) SUBGROUP ANALYSIS by gestational age.
[Analysis 7.29]
Analysis 7.29. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 29 Severe anaemia at any time during the 2nd and 3rd trimesters (Hb less than 70 g/L) SUBGROUP ANALYSIS by anaemia status.
[Analysis 7.30]
Analysis 7.30. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 30 Severe anaemia at any time during the 2nd and 3rd trimesters (Hb less than 70 g/L) SUBGROUP ANALYSIS by intermittent regimen.
[Analysis 7.31]
Analysis 7.31. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 31 Severe anaemia at any time during the 2nd and 3rd trimesters (Hb less than 70 g/L) SUBGROUP ANALYSIS by weekly dose of iron.
[Analysis 7.34]
Analysis 7.34. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 34 Very low birthweight (less than 1500 g) (ALL).
[Analysis 7.35]
Analysis 7.35. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 35 Very premature birth (less than 34 weeks of gestation) (ALL).
[Analysis 7.36]
Analysis 7.36. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 36 Infant ferritin concentration in the first 6 months (μg/L, counting the last reported measured after birth within this period) (ALL).
[Analysis 7.37]
Analysis 7.37. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 37 Maternal anaemia at or near term (Hb less than 110 g/L at 34 weeks' gestation or more) (ALL).
[Analysis 7.38]
Analysis 7.38. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 38 Maternal iron deficiency anaemia at or near term (Hb less than 110 g/L and at least one additional laboratory indicators at 34 weeks gestation or more) (ALL).
[Analysis 7.39]
Analysis 7.39. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 39 Maternal haemoglobin concentration at or near term (g/L, at 34 weeks' gestation or more) (ALL).
[Analysis 7.40]
Analysis 7.40. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 40 Maternal high haemoglobin concentrations during second or third trimester (Hb more than 130 g/L) (ALL).
[Analysis 7.41]
Analysis 7.41. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 41 Moderate anaemia at any time during second or third trimester (Hb between 70 and 99 g/L)(ALL).
[Analysis 7.42]
Analysis 7.42. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 42 Moderate anaemia at postpartum (Hb between 80 and 109 g/L) (ALL).
[Analysis 7.43]
Analysis 7.43. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 43 Severe anaemia at term (Hb less than 70 g/L at 37 weeks' gestation or more) (ALL).
[Analysis 7.44]
Analysis 7.44. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 44 Severe anaemia at postpartum (Hb less than 80 g/L) (ALL).
[Analysis 7.45]
Analysis 7.45. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 45 Antepartum haemorrhage (ALL).
[Analysis 7.46]
Analysis 7.46. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 46 Diarrhoea (ALL).
[Analysis 7.47]
Analysis 7.47. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 47 Constipation (ALL).
[Analysis 7.48]
Analysis 7.48. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 48 Nausea (ALL).
[Analysis 7.49]
Analysis 7.49. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 49 Heartburn (ALL).
[Analysis 7.50]
Analysis 7.50. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 50 Vomiting (ALL).
[Analysis 7.51]
Analysis 7.51. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 51 Placental abruption (ALL).
[Analysis 7.52]
Analysis 7.52. Comparison 7 Intermittent oral iron+folic acid supplementation versus daily iron+folic acid supplementation, Outcome 52 Premature rupture of membranes (ALL).
[Analysis 8.6]
Analysis 8.6. Comparison 8 Intermittent oral iron+vitamins and minerals supplementation versus daily iron+vitamins and minerals supplementation, Outcome 6 Maternal anaemia at term (Hb less than 110 g/L at 37 weeks' gestation or more) (ALL).
[Analysis 8.10]
Analysis 8.10. Comparison 8 Intermittent oral iron+vitamins and minerals supplementation versus daily iron+vitamins and minerals supplementation, Outcome 10 Side effects (any reported throughout intervention period) (ALL).
[Analysis 8.13]
Analysis 8.13. Comparison 8 Intermittent oral iron+vitamins and minerals supplementation versus daily iron+vitamins and minerals supplementation, Outcome 13 Very premature birth (less than 34 weeks of gestation) (ALL).
[Analysis 8.14]
Analysis 8.14. Comparison 8 Intermittent oral iron+vitamins and minerals supplementation versus daily iron+vitamins and minerals supplementation, Outcome 14 Maternal anaemia at or near term (Hb less than 110 g/L at 34 weeks' gestation or more) (ALL).
[Analysis 8.15]
Analysis 8.15. Comparison 8 Intermittent oral iron+vitamins and minerals supplementation versus daily iron+vitamins and minerals supplementation, Outcome 15 Maternal iron deficiency at or near term (based on any indicator of iron status at 34 weeks' gestation or more) (ALL).
[Analysis 8.16]
Analysis 8.16. Comparison 8 Intermittent oral iron+vitamins and minerals supplementation versus daily iron+vitamins and minerals supplementation, Outcome 16 Maternal haemoglobin concentration at or near term (g/L, at 34 weeks' gestation or more) (ALL).
[Analysis 8.17]
Analysis 8.17. Comparison 8 Intermittent oral iron+vitamins and minerals supplementation versus daily iron+vitamins and minerals supplementation, Outcome 17 Maternal high haemoglobin concentrations during second or third trimester (Hb more than 130 g/L) (ALL).
[Analysis 8.18]
Analysis 8.18. Comparison 8 Intermittent oral iron+vitamins and minerals supplementation versus daily iron+vitamins and minerals supplementation, Outcome 18 Severe anaemia at term (Hb less than 70 g/L at 37 weeks' gestation or more) (ALL).
[Analysis 8.19]
Analysis 8.19. Comparison 8 Intermittent oral iron+vitamins and minerals supplementation versus daily iron+vitamins and minerals supplementation, Outcome 19 Severe anaemia at any time during second and third trimester (Hb less than 70 g/L) (ALL).