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FSH replaced by low-dose hCG in the late follicular phase versus continued FSH for assisted reproductive techniques

  1. Wellington P Martins*,
  2. Andrea DD Vieira,
  3. Jaqueline BP Figueiredo,
  4. Carolina O Nastri

Editorial Group: Cochrane Gynaecology and Fertility Group

Published Online: 28 MAR 2013

Assessed as up-to-date: 5 FEB 2013

DOI: 10.1002/14651858.CD010042.pub2


How to Cite

Martins WP, Vieira ADD, Figueiredo JBP, Nastri CO. FSH replaced by low-dose hCG in the late follicular phase versus continued FSH for assisted reproductive techniques. Cochrane Database of Systematic Reviews 2013, Issue 3. Art. No.: CD010042. DOI: 10.1002/14651858.CD010042.pub2.

Author Information

  1. University of Sao Paulo, Department of Obstetrics and Gynecology, Medical School of Ribeirao Preto, Ribeirao Preto, Sao Paulo, Brazil

*Wellington P Martins, Department of Obstetrics and Gynecology, Medical School of Ribeirao Preto, University of Sao Paulo, Hospital das Clinicas da FMRP-USP, 8 andar, Campus Universitario da USP, Ribeirao Preto, Sao Paulo, 14048-900, Brazil. wpmartins@gmail.com.

Publication History

  1. Publication Status: New
  2. Published Online: 28 MAR 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Aflatoonian 2012 {published data only}
  • Aflatoonian A, Yousefnejad F, Eftekhar M, Mohammadian F. Efficacy of low-dose hCG in late follicular phase in controlled ovarian stimulation using GnRH agonist protocol. Archives of Gynecology and Obstetrics 2012;286(3):771-5. [PUBMED: 22619027]
Ashrafi 2011 {published data only}
  • Ashrafi M,  Kiani K,  Ghasemi A,  Rastegar F,  Nabavi M. The effect of low dose human chorionic gonadotropin on follicular response and oocyte maturation in PCOS patients undergoing IVF cycles: a randomized clinical trial of efficacy and safety. Archives of Gynecology and Obstetrics 2011;284(6):1431-8. [PUBMED: 21210134]
Blockeel 2009 {published data only}
  • Blockeel C,  De Vos M,  Verpoest W,  Stoop D,  Haentjens P,  Devroey P. Can 200 IU of hCG replace recombinant FSH in the late follicular phase in a GnRH-antagonist cycle? A pilot study. Human Reproduction 2009;24(11):2910-6. [PUBMED: 19617207]
Filicori 2005a {published data only}
  • Filicori M, Cognigni GE, Parmegiani L, Taraborrelli S, Gamberini E, Bernardi S. Stimulation of folliculogenesis with low-dose human chorionic gonadotropin(hCG) alone in ovulation induction. Fertility and Sterility. 2004; Vol. 82:S3.
  • Filicori M,  Cognigni GE,  Gamberini E,  Parmegiani L,  Troilo E,  Roset B. Efficacy of low-dose human chorionic gonadotropin alone to complete controlled ovarian stimulation. Fertility and Sterility 2005;84(2):394-401. [PUBMED: 16084880]
  • Filicori M,  Cognigni GE,  Parmegiani L,  Taraborrelli S, Tabarelli C, Gamberini E, et al. Efficacy of low-dose hCG in ovarian stimulation. Human Reproduction. 2004; Vol. 19 Suppl 1:i119-20.
Gomes 2007 {published data only}
  • Gomes MK,  Vieira CS,  Moura MD,  Manetta LA,  Leite SP,  Reis RM,  et al. Controlled ovarian stimulation with exclusive FSH followed by stimulation with hCG alone, FSH alone or hMG. European Journal of Obstetrics, Gynecology, and Reproductive Biology 2007;130(1):99-106. [PUBMED: 16835006]

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Beretsos 2009 {published data only}
  • Beretsos P,  Partsinevelos GA,  Arabatzi E,  Drakakis P,  Mavrogianni D,  Anagnostou E,  et al. "hCG priming" effect in controlled ovarian stimulation through a long protocol. Reproductive Biology and Endocrinology 2009;31(7):91. [PUBMED: 19719843]
Berkkanoglu 2007 {published data only}
  • Berkkanoglu M,  Isikoglu M,  Aydin D,  Ozgur K. Clinical effects of ovulation induction with recombinant follicle-stimulating hormone supplemented with recombinant luteinizing hormone or low-dose recombinant human chorionic gonadotropin in the midfollicular phase in microdose cycles in poor responders. Fertility and Sterility 2007;88(3):665-9. [PUBMED: 17292895]
Check 2009 {published data only}
  • Check JH, Davies E, Brasile D, Choe JK, Amui J. A prospective comparison of in vitro fertilization (IVF) outcome following controlled ovarian hyperstimulation (COH) regimens using follitropin alpha exclusively or with the addition of low dose human chorionic gonadotropin (hCG) and ganirelix. Clinical and Experimental Obstetrics & Gynecology 2009;36(4):217-8. [PUBMED: 20101851]
Dehghani-Firouzabady 2006 {published data only}
  • Dehghani-Firouzabady R, Asgharnia M, Tayebi N, Kalantar SM. Use of low-dose human chorionic gonadotropin (hCG) for final follicular maturation in ovulatory women treated by intrauterine insemination. Middle East Fertility Society Journal 2006;11(3):201-5.
Drakakis 2009 {published data only}
  • Drakakis P,  Loutradis D,  Beloukas A,  Sypsa V,  Anastasiadou V,  Kalofolias G,  et al. Early hCG addition to rFSH for ovarian stimulation in IVF provides better results and the cDNA copies of the hCG receptor may be an indicator of successful stimulation. Reproductive Biology and Endocrinology 2009;13(7):110. [PUBMED: 19825188]
Filicori 1999 {published data only}
  • Filicori M,  Cognigni GE,  Taraborrelli S,  Spettoli D,  Ciampaglia W,  de Fatis CT,  et al. Luteinizing hormone activity supplementation enhances follicle-stimulating hormone efficacy and improves ovulation induction outcome. The Journal of Clinical Endocrinology and Metabolism 1999;84(8):2659-63. [PUBMED: 10443656]
Filicori 2002 {published data only}
  • Filicori M,  Cognigni GE,  Tabarelli C,  Pocognoli P,  Taraborrelli S,  Spettoli D,  Ciampaglia W. Stimulation and growth of antral ovarian follicles by selective LH activity administration in women. The Journal of Clinical Endocrinology and Metabolism 2002;87(3):1156-61. [PUBMED: 11889180]
Filicori 2005b {published data only}
  • Filicori M, Cognini GE, Ferlini F, Ciampaglia W, Pocognoli P, Parmegiani L, Troilo E, Bernardi S, Gamberini E. Prospective randomized, dose finding study of low-dose human chorionic gonadotropin (hCG) administration in controlled ovarian stimulation (COS). Abstracts of the 21st Annual Meeting of the ESHRE. 2005:i64-5.
Koichi 2006 {published data only}
  • Koichi K,  Yukiko N,  Shima K,  Sachiko S. Efficacy of low-dose human chorionic gonadotropin (hCG) in a GnRH antagonist protocol. Journal of Assisted Reproduction and Genetics 2006;23(5):223-8. [PUBMED: 16786420]
  • Kyono K, Fuchinoue K, Nakajo Y, Yagi A, Sasaki K. A prospective randomized study of three ovulation induction protocols for IVF: GnRH agonist versus antagonist with and without low dose hCG. Fertility and Sterility. 2004; Vol. 82:s31.
Lossl 2008 {published data only}
  • Lossl K,  Andersen CY,  Loft A,  Freiesleben NL,  Bangsbøll S,  Andersen AN. Short-term androgen priming by use of aromatase inhibitor and hCG before controlled ovarian stimulation for IVF. A randomized controlled trial. Human Reproduction 2008;23(8):1820-9. [PUBMED: 18487212]
Mendes 2005 {published data only}
  • Mendes IR, Kotecki JA, Caldeira G, Lazar F, Serafini PC, Motta EL. Will the administration of low-dose hCG for ovulation induction in association with bromocriptine aid in the prevention of OHSS?. Fertility and Sterility. 2005; Vol. 84:S313.
Serafini 2006 {published data only}
  • Serafini P,  Yadid I,  Motta EL,  Alegretti JR,  Fioravanti J,  Coslovsky M. Ovarian stimulation with daily late follicular phase administration of low-dose human chorionic gonadotropin for in vitro fertilization: a prospective, randomized trial. Fertility and Sterility 2006;86(4):830-8. [PUBMED: 16963040]
Thuesen 2012 {published data only}
  • Thuesen LL, Loft A, Egeberg AN, Smitz J, Petersen JH, Nyboe Andersen A. A randomized controlled dose-response pilot study of addition of hCG to recombinant FSH during controlled ovarian stimulation for in vitro fertilization. Human Reproduction 2012;27(10):3074-84. [PUBMED: 22791754]
  • Thuesen LL, Loft A, Egeberg AN, Smitz J, Petersen JH, Nyboe Andersen A. Supplementation with hCG to recombinant FSH during controlled ovarian stimulation for in vitro fertilisation: a randomised controlled dose-finding study. Human Reproduction. 2011; Vol. 26 Suppl 1:i27-8.
Van Horne 2007 {published data only}
  • Van Horne AK,  Bates GW Jr,  Robinson RD,  Arthur NJ,  Propst AM. Recombinant follicle-stimulating hormone (rFSH) supplemented with low-dose human chorionic gonadotropin compared with rFSH alone for ovarian stimulation for in vitro fertilization. Fertility and Sterility 2007;88(4):1010-3. [PUBMED: 17434503]

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Aleyamma 2011
Checa 2012
  • Checa MA,  Espinós JJ,  Requena A. Efficacy and safety of human chorionic gonadotropin for follicular phase stimulation in assisted reproduction: a systematic review and meta-analysis. Fertility and Sterility 2012;97(6):1343-50. [PUBMED: 22464087]
Filicori 2002a
  • Filicori M, Cognigni GE, Samara A, Melappioni S, Perri T, Cantelli B, et al. The use of LH activity to drive folliculogenesis: exploring uncharted territories in ovulation induction. Human Reproduction Update 2002;8(6):543-57. [PUBMED: 12498424]
Filicori 2002b
  • Filicori M, Cognigni GE, Tabarelli C, Pocognoli P, Taraborrelli S, Spettoli D, et al. Stimulation and growth of antral ovarian follicles by selective LH activity administration in women. The Journal of Clinical Endocrinology and Metabolism 2002;87(3):1156-61. [PUBMED: 11889180]
Gnoth 2011
Higgins 2011
  • Higgins J, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Kosmas 2009
  • Kosmas IP, Zikopoulos K, Georgiou I, Paraskevaidis E, Blockeel C, Tournaye H, et al. Low-dose HCG may improve pregnancy rates and lower OHSS in antagonist cycles: a meta-analysis. Reproductive Biomedicine Online 2009;19(5):619-30. [PUBMED: 20021711]
Macklon 2006
  • Macklon NS,  Stouffer RL,  Giudice LC,  Fauser BC. The science behind 25 years of ovarian stimulation for in vitro fertilization. Endocrine Reviews 2006;27(2):170-207. [PUBMED: 16434510]
Nastri 2010
  • Nastri CO, Ferriani RA, Rocha IA, Martins WP. Ovarian hyperstimulation syndrome: pathophysiology and prevention. Journal of Assisted Reproduction and Genetics 2010;27(2-3):121-8. [PUBMED: 20140640]
Pelinck 2006
  • Pelinck MJ, Vogel NE, Hoek A, Simons AH, Arts EG, Mochtar MH, et al. Cumulative pregnancy rates after three cycles of minimal stimulation IVF and results according to subfertility diagnosis: a multicentre cohort study. Human Reproduction 2006;21(9):2375-83. [PUBMED: 16751647]
Ross 1977
  • Ross GT. Clinical relevance of research on the structure of human chorionic gonadotropin. American Journal of Obstetrics and Gynecology 1977;129(7):795-808. [PUBMED: 343593]
Shima 1987
  • Shima K, Kitayama S, Nakano R. Gonadotropin binding sites in human ovarian follicles and corpora lutea during the menstrual cycle. Obstetrics and Gynecology 1987;69(5):800-6. [PUBMED: 3106871]
Takao 1997
  • Takao Y, Honda T, Ueda M, Hattori N, Yamada S, Maeda M, et al. Immunohistochemical localization of the LH/HCG receptor in human ovary: hCG enhances cell surface expression of LH/HCG receptor on luteinizing granulosa cells in vitro. Molecular Human Reproduction 1997;3(7):569-78. [PUBMED: 9268134]
Thoma 2013
  • Thoma ME,  McLain AC,  Louis JF,  King RB,  Trumble AC,  Sundaram R,  et al. Prevalence of infertility in the United States as estimated by the current duration approach and a traditional constructed approach. Fertility and Sterility 2013;in press. [PUBMED: 23290741]
Verberg 2009
Zegers-Hochschild 2009
  • Zegers-Hochschild F, Adamson GD, de Mouzon J, Ishihara O, Mansour R, Nygren K, et al. International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Human Reproduction 2009;24(11):2683-7. [PUBMED: 19828144]