Intervention Review

You have free access to this content

Mechanical insufflation-exsufflation for people with neuromuscular disorders

  1. Brenda Morrow1,*,
  2. Marco Zampoli2,
  3. Helena van Aswegen3,
  4. Andrew Argent4

Editorial Group: Cochrane Neuromuscular Disease Group

Published Online: 30 DEC 2013

Assessed as up-to-date: 7 OCT 2013

DOI: 10.1002/14651858.CD010044.pub2


How to Cite

Morrow B, Zampoli M, van Aswegen H, Argent A. Mechanical insufflation-exsufflation for people with neuromuscular disorders. Cochrane Database of Systematic Reviews 2013, Issue 12. Art. No.: CD010044. DOI: 10.1002/14651858.CD010044.pub2.

Author Information

  1. 1

    University of Cape Town, Department of Paediatrics, Cape Town, South Africa

  2. 2

    Red Cross War Memorial Children's Hospital and University of Cape Town, Pulmonology, and Paediatric Medicine, Cape Town, South Africa

  3. 3

    University of the Witwatersrand, Physiotherapy Department, Faculty of Health Sciences, Johannesburg, South Africa

  4. 4

    Red Cross War Memorial Children's Hospital and University of Cape Town, Pediatric Intensive Care, Division of Pediatric Critical Care and Children's Heart Disease, Cape Town, South Africa

*Brenda Morrow, Department of Paediatrics, University of Cape Town, 5th Floor ICH Building, Red Cross Memorial Children's Hospital, Klipfontein Road, Rondebosch, 7700, Cape Town, South Africa. Brenda.morrow@uct.ac.za.

Publication History

  1. Publication Status: New
  2. Published Online: 30 DEC 2013

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Chatwin 2003 {published data only (unpublished sought but not used)}
  • Chatwin M, Ross E, Hart N, Nickol AH, Polkey MI, Simonds AK. Cough augmentation with mechanical insufflation/exsufflation in patients with neuromuscular weakness. European Respiratory Journal 2003;21(3):502-8. [PUBMED: 12662009]
Chatwin 2009 {published data only}
  • Chatwin M, Simonds AK. The addition of mechanical insufflation/exsufflation shortens airway-clearance sessions in neuromuscular patients with chest infection. Respiratory Care 2009;54(11):1473-9. [PUBMED: 19863831]
Mustfa 2003 {published data only}
  • Mustfa N, Aiello M, Lyall RA, Nikoletou D, Olivieri D, Leigh PN, et al. Cough augmentation in amyotrophic lateral sclerosis. Neurology 2003;61(9):1285-7. [PUBMED: 14610141]
Senent 2011 {published data only}
  • Senent C, Golmard JL, Salachas F, Chiner E, Morelot-Panzini C, Meninger V, et al. A comparison of assisted cough techniques in stable patients with severe respiratory insufficiency due to amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis 2011;12(1):26-32. [PUBMED: 21091398]
Sivasothy 2001 {published data only}
  • Sivasothy P, Brown L, Smith IE, Shneerson JM. Effect of manually assisted cough and mechanical insufflation on cough flow of normal subjects, patients with chronic obstructive pulmonary disease (COPD), and patients with respiratory muscle weakness. Thorax 2001;56(6):438-44. [PUBMED: 11359958]

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Sancho 2003 {published data only}
  • Sancho J, Servera E, Vergara P, Marín J. Mechanical insufflation-exsufflation vs. tracheal suctioning via tracheostomy tubes for patients with amyotrophic lateral sclerosis: a pilot study. American Journal of Physical Medicine and Rehabiltation 2003;82(10):750-3. [PUBMED: 14508404]
Trebbia 2005 {published data only}
  • Trebbia G, Lacombe M, Fermanian C, Falaize L, Lejaille M, Louis A, et al. Cough determinants in patients with neuromuscular disease. Respiratory Physiology & Neurobiology 2005;146(2-3):291-300. [PUBMED: 15766917]
Vitacca 2010 {published data only}
  • Vitacca M, Paneroni M, Trainini D, Bianchi L, Assoni G, Saleri M, et al. At home and on demand mechanical cough assistance program for patients with amyotrophic lateral sclerosis. American Journal of Physical Medicine & Rehabilitation 2010;89(5):401-6. [PUBMED: 20407305]

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
NCT01518439 {published data only (unpublished sought but not used)}
  • Instrumental and Manual Increase of Couch [sic] in Neuromuscular Patients. Ongoing study January 2012.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Albuali 2007
  • Albuali WH, Singh RN, Fraser DD, Seabrook JA, Kavanagh BP, Parshuram CS, et al. Have changes in ventilation practice improved outcome in children with acute lung injury?. Pediatric Critical Care Medicine 2007;8(4):324-30.
Anderson 2005
  • Anderson JL, Hasney KM, Beaumont NE. Systematic review of techniques to enhance peak cough flow and maintain vital capacity in neuromuscular disease: the case for mechanical insufflation-exsufflation. Physical Therapy Reviews 2005;10(1):25-33.
Bach 1993
  • Bach JR. Mechanical insufflation-exsufflation. Comparison of peak expiratory flows with manually assisted and unassisted coughing techniques. Chest 1993;104(5):1533-62.
Bach 1995
Bach 1996
  • Bach JR. A historical perspective on the use of noninvasive ventilatory support alternatives. Respiratory Care Clinics of North America 1996;2(2):161-81.
Bach 1997
Bach 2000
Bach 2003
Bannister 1985
  • Bannister R. Brain's Clinical Neurology. 6th Edition. Oxford: Oxford University Press, 1985:427-467.
Barach 1952
  • Barach AL, Beck GJ, Bickerman HA, Seanor HE, Smith W. Physical methods simulating mechanisms of the human cough. Journal of Applied Physiology 1952;5(2):85-91.
Boitano 2006
Boitano 2009
Bott 2009
  • Bott J, Blumenthal S, Buxton M, Ellum S, Falconer C, Garrod R, et al. Guidelines for the physiotherapy management of the adult, medical, spontaneously breathing patient. Thorax 2009;64 Suppl 1:i1-51.
Boyer 2006
  • Boyer F, Morrone I, Laffont I, Dizien O, Etienne JC, Novella JL. Health related quality of life in people with hereditary neuromuscular diseases: an investigation of test-retest agreement with comparison between two generic questionnaires, the Nottingham health profile and the short form-36 items. Neuromuscular Disorders 2006;16(2):99-106.
Chatwin 2011
  • Chatwin M, Bush A, Simonds AK. Outcome of goal-directed non-invasive ventilation and mechanical insufflation/exsufflation in spinal muscular atrophy type I. Archives of Diseases in Childhood 2011;96(5):426-32.
Deeks 2011
  • Deeks JJ, Higgins JPT, Altman DG (editors). Chapter 9: Analysing data and undertaking meta-analyses. In: Higgins JPT, Green S editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Fauroux 2008
  • Fauroux B, Guillemot N, Aubertin G, Nathan N, Labit A, Cément A, et al. Physiologic benefits of mechanical insufflation-exsufflation in children with neuromuscular diseases. Chest 2008;133(1):161-8.
Finder 2004
  • Finder JD, Birnkrant D, Carl J, Farber HJ, Gonzal D, Iannaccone ST, et al. American Thoracic Society. Respiratory care of the patient with Duchenne muscular dystrophy: ATS consensus statement. American Journal of Respiratory and Critical Care Medicine 2004;170(4):456-65.
Finder 2010
Gattinoni 2003
  • Gattinoni L, Carlesso E, Cadringher P, Valenza F, Vagginelli F, Chiumello D. Physical and biological triggers of ventilator-induced lung injury and its prevention. European Respiratory Journal 2003;22 Suppl 47:15s-25s.
Gattinoni 2010
  • Gattinoni L, Protti A, Caironi P, Carlesso E. Ventilator-induced lung injury: the anatomical and physiological framework. Critical Care Medicine 2010;38(10 Suppl):S539-48.
Gozal 2000
Gómez-Merino 2002
  • Gómez-Merino E, Sancho J, Marín J, Servera E, Blasco ML, Belda JF, et al. Mechanical insufflation-exsufflation: pressure, volume, and flow relationships and the adequacy of the manufacturer's guidelines. American Journal of Physical Medicine and Rehabilitation 2002;81(8):579-83.
Hanayama 1997
  • Hanayama K, Ishikawa Y, Bach JR. Amyotrophic lateral sclerosis. Successful treatment of mucous plugging by mechanical insufflation-exsufflation. American Journal of Physical Medicine and Rehabilitation 1997;76(4):338-9.
Higgins 2003
Higgins 2011a
  • Higgins JPT, Altman DG, Sterne JAC (editors). Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org. Chichester: John Wiley & Sons.
Higgins 2011b
  • Higgins JPT, Deeks JJ, Altman DG (editors). Chapter 16: Special topics in statistics. In: Higgins JPT, Green S (editors), Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Higgins 2011c
  • Higgins JPT, Deeks JJ (editors). Chapter 7: Selecting studies and collecting data. In: Higgins JPT, Green S editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Homnick 2007
  • Homnick DN. Mechanical insufflation-exsufflation for airway mucus clearance. Respiratory Care 2007;52(10):1296-305; discussion 1306-7.
Iannaccone 2007
McCool 2006
Miske 2004
  • Miske LJ, Hickey EM, Kolb SM, Weiner DJ, Panitch HB. Use of the mechanical in-exsufflator in pediatric patients with neuromuscular disease and impaired cough. Chest 2004;125(4):1406-12.
Morrow 2008
Panitch 2009
Papastamelos 1996
  • Papastamelos C, Panitch HB, Allen JL. Chest wall compliance in infants and children with neuromuscular disease. American Journal of Critical Care Medicine 1996;154(4 Pt 1):1045-8.
Ramsay 2003
  • Ramsay C. Methodology in the Cochrane Effective Practice and Organisation of Care Group. How do you include trials with more than two groups into a single meta-analysis?. http://epoc.cochrane.org/sites/epoc.cochrane.org/files/uploads/FAQmultip 2003. (accessed 23 November 2011).
Reid 1994
  • Reid DT, Renwick RM. Preliminary validation of a new instrument to measure life satisfaction in adolescents with neuromuscular disorders. International Journal of Rehabilitation Research 1994;17(2):184-8.
Respironics 2009
  • Philips Respironics. CoughAssist protocol. http://coughassist.org/coughassistprotocol (accessed 23 November 2011).
RevMan 2012
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
Robbins 2001
  • Robbins RA, Simmons Z, Bremer BA, Walsh SM, Fischer S. Quality of life in ALS is maintained as physical function declines. Neurology 2001;56(4):442-4.
Rosiere 2009
  • Rosière J, Vader JP, Cavin MS, Grant K, Larcinese A, Voellinger R, et al. Appropriateness of respiratory care: evidence-based guidelines. Swiss Medical Weekly 2009;139(27-28):387-92.
Saharan 2010
Sharma 2009
Sterne 2011
  • Sterne JAC, Egger M, Moher D (editors). Chapter 10: Addressing reporting biases. In: Higgins JPT, Green S editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Suri 2008
  • Suri P, Burns SP, Bach JR. Pneumothorax associated with mechanical insufflation-exsufflation and related factors. American Journal of Physical Medicine & Rehabilitation 2008;87(11):951-5.
Tzeng 2000
Vianello 2004
  • Vianello A, Arcaro G, Gallan F, Ori C, Bevilacqua M. Pneumothorax associated with long-term non-invasive positive pressure ventilation in Duchenne muscular dystrophy. Neuromuscular Disorders 2004;14(6):353-5.
Vianello 2005
  • Vianello A, Corrado A, Aracaro G, Gallan F, Ori C, Minuzzo M, et al. Mechanical insufflation-exsufflation improves outcomes for neuromuscular disease patients with respiratory tract infections. American Journal of Physical Medicine & Rehabilitation 2005;84(2):83-8.
Wang 2007
  • Wang CH, Finkel RS, Bertini ES, Schroth M, Simonds A, Wong B, et al. Participants of the International Conference on SMA Standard of Care. Consensus statement for standard of care in spinal muscular atrophy. Journal of Child Neurology 2007;22(8):1027-49.
Wang 2010
  • Wang CH, Bonnemann CG, Rutkowski A, Sejersen T, Bellini J, Battista V, et al. International Standard of Care Committee for Congenital Muscular Dystrophy. Consensus statement on standard of care for congenital muscular dystrophies. Journal of Child Neurology 2010;25(12):1559-81.
Whitney 2002
  • Whitney J, Harden B, Kielty S. Assisted cough: a new technique. Physiotherapy 2002;88(4):201-7.
Winck 2004
  • Winck JC, Gonçalves CL, Lourenço C, Viana P, Almeida J, Bach JR. Effects of mechanical insufflation-exsufflation on respiratory parameters for patients with chronic airway secretion encumbrance. Chest 2004;126(3):774-80.

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Morrow 2012
  • Morrow B, Zampoli M, van Aswegen H, Argent A. Mechanical insufflation-exsufflation for people with neuromuscular disorders. Cochrane Database of Systematic Reviews 2012, Issue 8. [DOI: 10.1002/14651858.CD010044]