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Prophylaxis for venous thromboembolism during asparaginase therapy in patients treated for acute lymphoblastic leukemia

  • Protocol
  • Intervention

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Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

Primary objectives of this review are:

  • to investigate and summarize whether thromboprophylactic measures are effective in reducing the incidence of VTE during asparaginase therapy in primary ALL remission induction treatment for pediatric and adult patients;

  • to investigate the impact of thromboprophylaxis used during primary ALL remission induction treatment on overall survival.

Secondary objectives of this review are:

  • to investigate and summarize the adverse effects of thromboprophylactic measures during asparaginase therapy in primary ALL remission induction treatment, to address their safety (Loke 2011);

  • to investigate and summarize which thromboprophylactic measure is the most effective in reducing the VTE incidence during asparaginase therapy in primary ALL remission induction treatment;

  • to investigate the impact of thromboprophylaxis used during asparaginase therapy in primary ALL remission induction treatment on ALL treatment outcome, expressed in complete remission rates.

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