Intervention Protocol

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm and/or low-birth-weight infants

  1. Arne Ohlsson1,*,
  2. Prakeshkumar S Shah2

Editorial Group: Cochrane Neonatal Group

Published Online: 12 SEP 2012

Assessed as up-to-date: 26 JUN 2012

DOI: 10.1002/14651858.CD010061


How to Cite

Ohlsson A, Shah PS. Paracetamol (acetaminophen) for patent ductus arteriosus in preterm and/or low-birth-weight infants (Protocol). Cochrane Database of Systematic Reviews 2012, Issue 9. Art. No.: CD010061. DOI: 10.1002/14651858.CD010061.

Author Information

  1. 1

    University of Toronto, Departments of Paediatrics, Obstetrics and Gynaecology and Institute of Health Policy, Management and Evaluation, Toronto, Ontario, Canada

  2. 2

    University of Toronto, Department of Paediatrics and Department of Health Policy, Management and Evaluation, Rm 775A, Toronto, Ontario, Canada

*Arne Ohlsson, Departments of Paediatrics, Obstetrics and Gynaecology and Institute of Health Policy, Management and Evaluation, University of Toronto, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada. aohlsson@mtsinai.on.ca.

Publication History

  1. Publication Status: New
  2. Published Online: 12 SEP 2012

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

Primary objectives

  1. To determine the efficacy and safety of iv or oral paracetamol compared with placebo or no intervention for closure of a PDA in preterm and/or low birth weight infants.
  2. To determine the efficacy and safety of iv or oral paracetamol compared with iv indomethacin, for closure of a PDA in preterm and/or low birth weight infants.
  3. To determine the efficacy and safety of iv or oral paracetamol compared with iv ibuprofen for closure of a PDA in preterm and/or low birth weight infants.
  4. To determine the efficacy and safety of iv or oral paracetamol compared with oral ibuprofen for closure of a PDA in preterm and/or low birth weight infants.
  5. To determine the efficacy and safety of iv or oral paracetamol compared with other cyclo-oxygenase inhibitors (separate analyses for different cyclo-oxygenase inhibitors) for closure of a PDA in preterm and/or low birth weight infants.

Secondary objectives

  1. To determine in subgroup analyses the efficacy and safety of paracetamol for closure of a PDA in relation to postnatal ages of < seven days, seven to 14 days and > 14 days at the time of administration of the first dose of paracetamol.
  2. To determine in subgroup analyses the efficacy and safety of paracetamol for closure of a PDA in relation to the following criteria:
    1. gestational age (< 28 weeks, 28 to 32 weeks, 33 to 36 weeks);
    2. birth weight (< 1000 g, 1000 to 1500 g, 1501 to 2500 g).

  1. gestational age (< 28 weeks, 28 to 32 weeks, 33 to 36 weeks);
  2. birth weight (< 1000 g, 1000 to 1500 g, 1501 to 2500 g).