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Sulthiame monotherapy for epilepsy

  1. Philip Milburn-McNulty1,*,
  2. Graham Powell1,
  3. Graeme J Sills2,
  4. Anthony G Marson2

Editorial Group: Cochrane Epilepsy Group

Published Online: 9 MAR 2014

Assessed as up-to-date: 24 OCT 2013

DOI: 10.1002/14651858.CD010062.pub2


How to Cite

Milburn-McNulty P, Powell G, Sills GJ, Marson AG. Sulthiame monotherapy for epilepsy. Cochrane Database of Systematic Reviews 2014, Issue 3. Art. No.: CD010062. DOI: 10.1002/14651858.CD010062.pub2.

Author Information

  1. 1

    The Walton Centre for Neurology & Neurosurgery NHS Foundation Trust, Liverpool, UK

  2. 2

    Institute of Translational Medicine, University of Liverpool, Department of Molecular and Clinical Pharmacology, Liverpool, Merseyside, UK

*Philip Milburn-McNulty, The Walton Centre for Neurology & Neurosurgery NHS Foundation Trust, Lower Lane, Fazakerley, Liverpool, L9 7LJ, UK. philmilburnmcnulty@gmail.com.

Publication History

  1. Publication Status: New
  2. Published Online: 9 MAR 2014

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Basnec 2005 {published data only (unpublished sought but not used)}
  • Basnec A, Skarpa D, Barisic N, Jurin M, Mucic-Pucic B. The risk of second seizure in children with benign childhood epilepsy with centrotemporal spikes without treatment—a prospective study [Rizik javljanja drugog napadaja u neliječene djece s benignom parcijalnom epilepsijom s centrotemporalnim šiljaka—prospektivno istraživanje]. Acta Medica Croatica 2005;59(1):59-62.
Li 2000 {published data only (unpublished sought but not used)}
  • Li JM, Li ZH, Jing YQ, Pan DM, et al. A randomized controlled multicenter clinical study on sulthiame in the treatment of GTCS [舒噻嗪治疗癫痫强直-阵挛发作随机对照多中心临床研究]. Journal of Clinical Neurology 2000;13(6):345-7.
Rating 1999 {published data only (unpublished sought but not used)}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Debus 2004 {published data only}
Griffiths 1964 {published data only}
Groppa 2006 {published data only}
  • Groppa S, Siniatchkin M, Siebner H, Stephani U. Reduction of motor cortex excitability by the anticonvulsant drug sulthiame: a TMS study. Epilepsia 2006;47(Suppl 3):123-4.
  • Siniatchkin M, Groppa S, Siebner H, Stephani U. A single dose of sulthiame induces a selective increase in resting motor threshold in human motor cortex: a transcranial magnetic stimulation study. Epilepsy Research 2006;72(1):18-24.
Ingram 1963 {published data only}
  • Ingram TT, Ratcliffe SG. Clinical trial of Ospolot in epilepsy. Developmental Medicine and Child Neurology 1963;June(5):313-5.
Livingston 1967 {published data only}
Moffat 1970 {published data only}

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Borggraefe 2013 {published data only}
  • Borggraefe I, Bonfert M, Bast T, Neubauer BA, Schotten KJ, Maßmann K, et al. Levetiracetam vs. sulthiame in benign epilepsy with centrotemporal spikes in childhood: a double-blinded, randomized, controlled trial (German HEAD Study). European Journal of Paediatric Neurology 2013;17(5):507-14.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
ISRCTN66730162 {published data only (unpublished sought but not used)}
  • O'Callaghan F. Investigating the relationship between sleep disturbance and learning in children with benign epilepsy of childhood with centrotemporal spikes (BECCTS): a randomised double blind placebo controlled crossover trial. http://www.controlled-trials.com/ISRCTN66730162.
ISRCTN97864911 {published data only (unpublished sought but not used)}
  • Heinen F. Head-to-head evaluation of the antiepileptic drugs, levetiracetam versus sulthiame, in a German multicentre, double-blind, controlled trial in children with benign epilepsy with centrotemporal spikes. http://www.controlled-trials.com/ISRCTN97864911/.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Bast 2003
Ben-Zeev 2004
Brodie 1996
Chahem 2007
Commission 1998
Engler 2003
  • Engler F, Maeder-Ingvar M, Roulet E, Deonna T. Treatment with sulthiame (ospolot) in benign partial epilepsy of childhood and related syndromes: an open clinical and EEG study. Neuropediatrics 2003;34(2):105-9.
Epilepsia 1997
  • [No author listed]. ILAE Commission Report. The epidemiology of the epilepsies: future directions. International League Against Epilepsy. Epilepsia 1997;38(5):615-8.
Go 2005
Gross-Selbeck 2001
  • Gross-Selbeck G. Current treatment strategies for seizures and in epilepsy in children. Monatsschrift fur Kinderheikunde 2001;149(11):1174-9.
Houghton 1974
Kirkham 2010
  • Kirkham J, Dwan K, Altman D, Gamble C, Dodd S, Smyth R, et al. The impact of outcome reporting bias in randomised controlled trials on a cohort of systematic reviews. BMJ 2010 Feb 15;340:c365.
Koepp 2002
  • Koepp MJ, Patsalos PN, Sander JWAS. Sulthiame in adults with refractory epilepsy and learning disability: an open trial. Epilepsy Research 2002;50(3):277-82.
Lefebvre 2011
  • Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. http://www.cochrane-handbook.org/.
Leniger 2002
Miyajima 2009
  • Miyajima T, Kumada T, Kimura N, Mikuni T, Fuji T. Sulthiame treatment for patients with intractable epilepsy. No To Hattatsu 2009;41(1):17-20.
Parmar 1998
Rating 2000
Sander 1993
Schmidt 1995
Sterne 2008
  • Sterne JAC, Egger M, Moher D. Chapter 10: Addressing reporting biases. In: Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1. The Cochrane Collaboration, 2008. http://www.cochrane-handbook.org/.
Weissbach 2010
  • Weissbach A, Tirosh I, Scheuerman O, Hoffer V, Garty BZ. Respiratory alkalosis and metabolic acidosis in a child treated with sulthiame. Pediatric Emergency Care 2010;26(10):752-3.
Williamson 2002
Wirrell 2008
  • Wirrell E, Sherman EMS, Vanmastrigt R, Hamiwka L. Deterioration in cognitive function in children with benign epilepsy of childhood with central temporal spikes treated with sulthiame. Journal of Child Neurology 2008;23(1):14-21.
World Health Organization 2001
  • Epilepsy; Aetiology, Epidemiology and Prognosis. Epilepsy: Aetiology, Epidemiology and Prognosis. Geneva, Switzerland: World Health Organization, 2001.