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Single dose oral ibuprofen plus codeine for acute postoperative pain in adults

  1. Sheena Derry,
  2. Samuel M Karlin,
  3. R Andrew Moore*

Editorial Group: Cochrane Pain, Palliative and Supportive Care Group

Published Online: 28 MAR 2013

Assessed as up-to-date: 28 FEB 2013

DOI: 10.1002/14651858.CD010107.pub2


How to Cite

Derry S, Karlin SM, Moore RA. Single dose oral ibuprofen plus codeine for acute postoperative pain in adults. Cochrane Database of Systematic Reviews 2013, Issue 3. Art. No.: CD010107. DOI: 10.1002/14651858.CD010107.pub2.

Author Information

  1. University of Oxford, Pain Research and Nuffield Department of Clinical Neurosciences, Oxford, Oxfordshire, UK

*R Andrew Moore, Pain Research and Nuffield Department of Clinical Neurosciences, University of Oxford, Pain Research Unit, Churchill Hospital, Oxford, Oxfordshire, OX3 7LE, UK. andrew.moore@ndcn.ox.ac.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 28 MAR 2013

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This is not the most recent version of the article. View current version (05 FEB 2015)

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Cooper 1982 {published data only}
  • Cooper SA, Engel J, Ladov M, Precheur H, Rosenheck A, Rauch D. Analgesic efficacy of an ibuprofen-codeine combination. Pharmacotherapy 1982;2(3):162-7.
Daniels 2011 {published data only}
  • Daniels SE, Goulder MA, Aspley S, Reader S. A randomised, five-parallel-group, placebo-controlled trial comparing the efficacy and tolerability of analgesic combinations including a novel single-tablet combination of ibuprofen/paracetamol for postoperative dental pain. Pain 2011;152(3):632-42. [DOI: 10.1016/j.pain.2010.12.012]
Frame 1986 {published data only}
  • Frame JW, Fisher SE, Pickvance NJ, Skene AM. A double-blind placebo-controlled comparison of three ibuprofen/codeine combinations and aspirin. British Journal of Oral and Maxillofacial Surgery 1986;24(2):122-9.
McQuay 1989 {published data only}
  • McQuay HJ, Carroll D, Watts PG, Juniper RP, Moore RA. Codeine 20 mg increases pain relief from ibuprofen 400 mg after third molar surgery. A repeat-dosing comparison of ibuprofen and an ibuprofen-codeine combination. Pain 1989;37(1):7-13.
Petersen 1993 {published data only}
  • Petersen JK, Hansson F, Strid S. The effect of an ibuprofen-codeine combination for the treatment of patients with pain after removal of lower third molars. Journal of Oral and Maxillofacial Surgery 1993;51(6):637-40.
Sunshine 1987 {published data only}
  • Sunshine A, Roure C, Olson N, Laska EM, Zorrilla C, Rivera J. Analgesic efficacy of two ibuprofen-codeine combinations for the treatment of postepisiotomy and postoperative pain. Clinical Pharmacology and Therapeutics 1987;42(4):374-80.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Carlos 1989 {published data only}
  • Carlos R, Sánchez J, González B, Costela JL, Torres A, Galdo JR. Comparative study of two combinations of ibuprofen-codeine versus its separate components in the treatment of postoperative pain. Revista Española de Anestesiología y Reanimación 1989;36 Suppl 1:48-9.
Cater 1985 {published data only}
  • Cater M, Brien PM, Pickvance NJ. A double-blind comparison of the new ibuprofen-codeine phosphate combination, zomepirac, and placebo in the relief of postepisiotomy pain. Clinical Therapeutics 1985;7:442–7.
Giles 1985 {published data only}
  • Giles AD, Pickvance NJ. Combination analgesia following oral surgery - a double-blind comparison of ibuprofen, codeine phosphate and two combination ratios. Clinical Trials Journal 1985;22:300-13.
Giles 1986 {published data only}
  • Giles AD, Hill CM, Shepherd JP, Stewart DJ, Pickvance NJ. A single dose assessment of an ibuprofen/codeine combination in postoperative dental pain. International Journal of Oral and Maxillofacial Surgery 1986;15:727–32.
Hellman 1992 {published data only}
  • Hellman M, Ahlström U, Andersson L, Strid S. Analgesic efficacy of an ibuprofen-codeine combination in patients with pain after removal of lower third molars. European Journal of Clinical Pharmacology 1992;43(4):347-50.
McQuay 1992 {published data only}
Norman 1985 {published data only}
  • Norman SL, Jeavons BI, O’Brien PM, Johnson IR, Hitchcock A, Noyelle RM, et al. A double-blind comparison of a new ibuprofen-codeine phosphate combination, codeine phosphate, and placebo in the relief of postepisiotomy pain. Clinical Therapeutics 1985;7:549–54.
Walton 1990 {published data only}

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Barden 2004
Cascarbi 2003
Chaparro 2012
Clarke 2012
Collins 1997
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Cooper 1991
  • Cooper SA. Single-dose analgesic studies: the upside and downside of assay sensitivity. In: Max MB, Portenoy RK, Laska EM editor(s). The design of analgesic clinical trials. Advances in Pain Research and Therapy. Vol. 18, New York: Raven Press, 1991:117-24.
Derry 2009
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Derry 2010
  • Derry S, Moore RA, McQuay HJ. Single dose oral codeine, as a single agent, for acute postoperative pain in adults. Cochrane Database of Systematic Reviews 2010, Issue 4. [DOI: 10.1002/14651858.CD008099.pub2]
FitzGerald 2001
Forrest 2002
Frei 2010
  • Frei MY, Nielsen S, Dobbin MD, Tobin CL. Serious morbidity associated with misuse of over-the-counter codeine-ibuprofen analgesics: a series of 27 cases. Medical Journal of Australia 2010;193(5):294-6.
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  • Hernández-Díaz S, García-Rodríguez LA. Epidemiologic assessment of the safety of conventional nonsteroidal anti-inflammatory drugs. The American Journal of Medicine 2001;110 Suppl 3A:20S-7S. [DOI: 10.1016/S0002-9343(00)00682-3]
Higgins 2011
  • Altman DG, Antes G, Gøtzsche P, Higgins JPT, Jüni P, Lewis S, et al. Assessing risk of bias in included studies. In: Higgins JPT, Altman DG, Sterne JAC editor(s). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 (updated March 2011). Available from www.cochrane-handbook.org. The Cochrane Collaboration, 2011.
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L'Abbé 1987
Li Wan Po 1998
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McAvoy 2011
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Moore 2008
  • Moore RA, Barden J, Derry S, McQuay HJ. Managing potential publication bias. In: McQuay HJ, Kalso E, Moore RA editor(s). Systematic Reviews in Pain Research: Methodology Refined. Seattle: IASP Press, 2008:15-23. [ISBN: 978-0-931092-69-5]
Moore 2011a
Moore 2011b
  • Moore RA, Straube S, Paine J, Derry S, McQuay HJ. Minimum efficacy criteria for comparisons between treatments using individual patient meta-analysis of acute pain trials: examples of etoricoxib, paracetamol, ibuprofen, and ibuprofen/paracetamol combinations after third molar extraction. Pain 2011;152(5):982-9. [DOI: 10.1016/j.pain.2010.11.030]
Moore 2012
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