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Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy and food hypersensitivity

  • Protocol
  • Intervention

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Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

Primary objective:

  • to determine the effect of higher PUFA intake during infancy to prevent subsequent allergic disease or food hypersensitivity.

Secondary objectives:

  • to determine the effect of specific PUFA supplements;

  • to determine the effect of PUFA supplements in 1) predominantly human milk fed infants, 2) predominantly cow or soy formula fed infants, 3) predominantly hydrolysed formula fed infants, and 4) infants who have commenced complementary feeding (solids);

  • to determine the effect of PUFAs in 1) infants not selected for risk of allergy or food hypersensitivity, 2) infants at low risk, and 3) infants at high risk of allergy or food hypersensitivity (at least one first-degree relative with allergic disease or food hypersensitivity);

  • to determine the effect of PUFAs in 1) low birth weight or preterm infants and 2) term infants.

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