This is not the most recent version of the article. View current version (21 NOV 2013)

Diagnostic Test Accuracy Protocol

Clinical assessment to screen for the detection of oral cavity cancer and potentially malignant disorders in apparently healthy adults

  1. Tanya Walsh1,*,
  2. Joseph LY Liu2,
  3. Paul Brocklehurst1,
  4. Mark Lingen3,
  5. Alexander R Kerr4,
  6. Graham Ogden5,
  7. Saman Warnakulasuriya6,
  8. Crispian Scully7

Editorial Group: Cochrane Oral Health Group

Published Online: 14 NOV 2012

DOI: 10.1002/14651858.CD010173

How to Cite

Walsh T, Liu JLY, Brocklehurst P, Lingen M, Kerr AR, Ogden G, Warnakulasuriya S, Scully C. Clinical assessment to screen for the detection of oral cavity cancer and potentially malignant disorders in apparently healthy adults (Protocol). Cochrane Database of Systematic Reviews 2012, Issue 11. Art. No.: CD010173. DOI: 10.1002/14651858.CD010173.

Author Information

  1. 1

    School of Dentistry, The University of Manchester, Manchester, UK

  2. 2

    Scottish Dental Clinical Effectiveness Programme, NHS Education for Scotland, University of Dundee, Dental Health Services Research Unit, Dundee, UK

  3. 3

    University of Chicago, Pritzker School of Medicine, Division of Biological Sciences, Department of Pathology, Chicago, Illinois, USA

  4. 4

    New York University College of Dentistry, Department of Oral and Maxillofacial Pathology, Radiology and Medicine, New York, USA

  5. 5

    University of Dundee, Unit of Oral Surgery & Medicine, School of Dentistry, Dundee, Scotland, UK

  6. 6

    King's College London, Department of Oral Medicine, London, UK

  7. 7

    University College London, Eastman Dental Institute for Oral Health Care Sciences, London, UK

*Tanya Walsh, School of Dentistry, The University of Manchester, Coupland III Building, Oxford Road, Manchester, M13 9PL, UK. tanya.walsh@manchester.ac.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 14 NOV 2012

SEARCH

This is not the most recent version of the article. View current version (21 NOV 2013)

 

Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

The objective of this review is to estimate the accuracy of the conventional oral examination (COE) used singly or in combination with another index test (Additional  Table 1) as a screening test for the detection of oral cancer and potentially malignant disorders (PMD) of the lip and oral cavity of apparently healthy adults.

The secondary objective of this review is to estimate the accuracy of the different tests with COE, when compared with each other.

We will use meta-regression to explore possible sources of heterogeneity, ways in which the observed diagnostic test accuracy varies according to particular characteristics. Covariates to be included in these analyses will include.

  • Characteristics of the study sample: prevalence of carcinoma or PMD disease in the study (> 50% prevalence), inclusion of HPV + adults, tobacco users / high alcohol consumption.
  • Target condition (oral squamous cell carcinoma alone or oral squamous cell carcinoma and PMD).
  • Attributes of the screening programme: prospective organised or opportunistic, type of reference standard (examination and clinical evaluation by physician with specialist knowledge or extended follow-up), operator (dental or general practice professionals or other healthcare workers).