Intervention Review

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Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain

  1. Christopher J Derry,
  2. Sheena Derry,
  3. R Andrew Moore*

Editorial Group: Cochrane Pain, Palliative and Supportive Care Group

Published Online: 24 JUN 2013

Assessed as up-to-date: 21 MAY 2013

DOI: 10.1002/14651858.CD010210.pub2


How to Cite

Derry CJ, Derry S, Moore RA. Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD010210. DOI: 10.1002/14651858.CD010210.pub2.

Author Information

  1. University of Oxford, Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), Oxford, Oxfordshire, UK

*R Andrew Moore, Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), University of Oxford, Pain Research Unit, Churchill Hospital, Oxford, Oxfordshire, OX3 7LE, UK. andrew.moore@ndcn.ox.ac.uk.

Publication History

  1. Publication Status: Stable (no update expected for reasons given in 'What's new')
  2. Published Online: 24 JUN 2013

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[Figure 1]
Figure 1. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 2]
Figure 2. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Figure 3]
Figure 3. Forest plot of comparison: ibuprofen 200 mg + paracetamol 500 mg versus placebo, outcome: 1.1 Participants with ≥50% pain relief.
[Figure 4]
Figure 4. Studies comparing ibuprofen 200 mg + paracetamol 500 mg with placebo, with the outcome of at least 50% maximum pain relief over 4 to 6 hours.
[Figure 5]
Figure 5. Forest plot of comparison: Ibuprofen 400 mg + paracetamol 1000 mg versus placebo, outcome: 2.1 Participants with ≥ 50% pain relief.
[Figure 6]
Figure 6. Studies comparing ibuprofen 400 mg plus paracetamol 1000 mg with placebo, with the outcome of at least 50% maximum pain relief over 4-6 hours
[Analysis 1.1]
Analysis 1.1. Comparison 1 ibuprofen 200 mg + paracetamol 500 mg versus placebo, Outcome 1 Participants with ≥50% pain relief.
[Analysis 1.2]
Analysis 1.2. Comparison 1 ibuprofen 200 mg + paracetamol 500 mg versus placebo, Outcome 2 Participants using rescue medication within 8 h.
[Analysis 1.3]
Analysis 1.3. Comparison 1 ibuprofen 200 mg + paracetamol 500 mg versus placebo, Outcome 3 Participants with any adverse event.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Ibuprofen 400 mg + paracetamol 1000 mg versus placebo, Outcome 1 Participants with ≥50% pain relief.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Ibuprofen 400 mg + paracetamol 1000 mg versus placebo, Outcome 2 Participants using rescue medication within 8 h.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Ibuprofen 400 mg + paracetamol 1000 mg versus placebo, Outcome 3 Participants with any adverse event.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Ibuprofen 400 mg + paracetamol 1000 mg versus ibuprofen 400 mg, Outcome 1 Participants with ≥50% pain relief.
[Analysis 3.2]
Analysis 3.2. Comparison 3 Ibuprofen 400 mg + paracetamol 1000 mg versus ibuprofen 400 mg, Outcome 2 Participants using rescue medication within 8 h.
[Analysis 3.3]
Analysis 3.3. Comparison 3 Ibuprofen 400 mg + paracetamol 1000 mg versus ibuprofen 400 mg, Outcome 3 Participants with any adverse event.