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Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain

  1. Christopher J Derry,
  2. Sheena Derry,
  3. R Andrew Moore*

Editorial Group: Cochrane Pain, Palliative and Supportive Care Group

Published Online: 24 JUN 2013

Assessed as up-to-date: 21 MAY 2013

DOI: 10.1002/14651858.CD010210.pub2


How to Cite

Derry CJ, Derry S, Moore RA. Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD010210. DOI: 10.1002/14651858.CD010210.pub2.

Author Information

  1. University of Oxford, Pain Research and Nuffield Department of Clinical Neurosciences, Oxford, Oxfordshire, UK

*R Andrew Moore, Pain Research and Nuffield Department of Clinical Neurosciences, University of Oxford, Pain Research Unit, Churchill Hospital, Oxford, Oxfordshire, OX3 7LJ, UK. andrew.moore@ndcn.ox.ac.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 24 JUN 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Daniels 2011 {published data only}
  • Daniels SE, Goulder MA, Aspley S, Reader S. A randomised, five-parallel-group, placebo-controlled trial comparing the efficacy and tolerability of analgesic combinations including a novel single-tablet combination of ibuprofen/paracetamol for postoperative dental pain. Pain 2011;152(3):632-42. [DOI: 10.1016/j.pain.2010.12.012]
Mehlisch 2010a {published and unpublished data}
  • A double-blind, parallel-group, placebo controlled randomized, single dose, two center, modified factorial design study comparing the analgesic efficacy of Advil® (400 mg ibuprofen), Tylenol® Extra Strength (1000 mg acetaminophen), the combination of Advil (400 mg ibuprofen) and Tylenol Extra Strength (1000 mg acetaminophen), and the combination of Advil (200 mg ibuprofen) and Tylenol Extra Strength (500 mg acetaminophen) in patients experiencing postoperative dental pain. Supplied as full clinical trial report by Reckitt Benckiser.
  • Mehlisch DR, Aspley S, Daniels SE, Bandy DP. Comparison of the analgesic efficacy of concurrent ibuprofen and paracetamol with ibuprofen or paracetamol alone in the management of moderate to severe acute postoperative dental pain in adolescents and adults: a randomized, double-blind, placebo-controlled, parallel-group, single-dose, two-center, modified factorial study. Clinical Therapeutics 2010;32(5):882-895. [DOI: 10.1016/j.clinthera.2010.04.022]
Mehlisch 2010b {published and unpublished data}
  • A double-blind, parallel-group, placebo-controlled, randomized, single and multiple-dose phase, multi-center factorial design, two-part study examining the analgesic efficacy and tolerability of three fixed-dose combinations of ibuprofen plus acetaminophen (ibuprofen 100 mg plus acetaminophen 250 mg, ibuprofen 200 mg plus acetaminophen 500 mg, ibuprofen 400 mg plus acetaminophen 1000 mg), ibuprofen alone (200 mg and 400 mg), and acetaminophen alone (500 mg and 1000 mg) in adult dental pain following third molar extraction. Supplied as full clinical trial report by Reckitt Benckiser.
  • Mehlisch DR, Aspley S, Daniels SE, Southerden KA, Christensen KS. A single-tablet fixed-dose combination of racemic ibuprofen/paracetamol in the management of moderate to severe postoperative dental pain in adult and adolescent patients: a multicenter, two-stage, randomized, double-blind, parallel-group, placebo-controlled, factorial study. Clinical Therapeutics 2010;32(6):1033-49. [DOI: 10.1016/j.clinthera.2010.06.002]

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Menhinick 2004 {published data only}
Merry 2010 {published data only}
  • Merry AF, Gibbs RD, Edwards J, Ting GS, Frampton C, Davies E, et al. Combined acetaminophen and ibuprofen for pain relief after oral surgery in adults: a randomized controlled trial. British Journal of Anaesthesia 2010;104(1):80–8. [DOI: 10.1093/bja/aep338]
Mitchell 2008 {published data only}
Naidu 1994 {published data only}
  • Naidu MU, Kumar TR, Jagdishchandra US, Babu PA, Rao MM, Babhulkar SS, et al. Evaluation of ketorolac, ibuprofen-paracetamol, and dextropropoxyphene-paracetamol in postoperative pain. Pharmacotherapy 1994;14(2):173-7.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
NCT00921700 {unpublished data only}
  • Skoglund LA (Study Director). Analgesic Effect of Paracetamol, Paracetamol + Codeine, Ibuprofen and Their Combination. www.clinicaltrials.gov/ct2/show/NCT00921700?term=ibuprofen+AND+paracetamol&rank=2 [accessed 11 October 2012].
NCT01559259 {unpublished data only}
  • Pfizer. Evaluation of the efficacy of novel ibuprofen acetaminophen combination formulations in the treatment of post-surgical dental pain. www.http://clinicaltrials.gov/ct2/show/NCT01559259?term=ibuprofen+AND+paracetamol&rank=8 [accessed 11 October 2012].

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
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Derry 2010
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