Intervention Review

You have free access to this content

Selenium supplementation for Hashimoto's thyroiditis

  1. Esther J van Zuuren1,*,
  2. Amira Y Albusta2,
  3. Zbys Fedorowicz3,
  4. Ben Carter4,
  5. Hanno Pijl5

Editorial Group: Cochrane Metabolic and Endocrine Disorders Group

Published Online: 6 JUN 2013

Assessed as up-to-date: 2 OCT 2012

DOI: 10.1002/14651858.CD010223.pub2

How to Cite

van Zuuren EJ, Albusta AY, Fedorowicz Z, Carter B, Pijl H. Selenium supplementation for Hashimoto's thyroiditis. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD010223. DOI: 10.1002/14651858.CD010223.pub2.

Author Information

  1. 1

    Leiden University Medical Center, Department of Dermatology, Leiden, Netherlands

  2. 2

    AMA International University of Bahrain, College of Medicine, Manama, Bahrain

  3. 3

    The Cochrane Collaboration, UKCC (Bahrain Branch), Awali, Bahrain

  4. 4

    Cardiff University School of Medicine, Institute of Primary Care & Public Health, Cardiff, UK

  5. 5

    Leiden University Medical Centre, Department of Endocrinology, Leiden, Netherlands

*Esther J van Zuuren, Department of Dermatology, Leiden University Medical Center, PO Box 9600, B1-Q, Leiden, 2300 RC, Netherlands.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 6 JUN 2013



References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Karanikas 2008 {published data only}
  • Karanikas G, Schuetz M, Kontur S, Duan H, Kommata S, Schoen R, et al. No immunological benefit of selenium in consecutive patients with autoimmune thyroiditis. Thyroid 2008;18(1):7-12. [PUBMED: PMID: 18302514]
Krysiak 2011 {published data only}
  • Krysiak R, Okopien B. The effect of levothyroxine and selenomethionine on lymphocyte and monocyte cytokine release in women with Hashimoto's thyroiditis. Journal of Clinical Endocrinology and Metabolism 2011;96(7):2206-15. [PUBMED: PMID: 21508145]
Negro 2007 {published data only}
  • Negro R, Greco G, Mangieri T, Pezzarossa A, Dazzi D, Hassan H. The influence of selenium supplementation on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies. Journal of Clinical Endocrinology and Metabolism 2007;92(4):1263-8. [PUBMED: PMID: 17284630]
Turker 2006 {published data only}
  • Turker O, Kumanlioglu K, Karapolat I, Dogan I. Selenium treatment in autoimmune thyroiditis: 9-month follow-up with variable doses. Journal of Endocrinology 2006;190(1):151-6. [PUBMED: PMID: 16837619]

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Balázs 2008 {published data only}
  • Balázs C. The effect of selenium therapy on autoimmune thyroiditis [A szelénkezelés hatásaaz autoimmun thyreoiditisre (Hungarian)]. Orvosi Hetilap 2008;149(26):1227-32. [PUBMED: PMID: 18565817]
Contempré 1992 {published data only}
Duntas 2003 {published data only}
  • Duntas LH, Mantzou E, Koutras DA. Effects of a six month treatment with selenomethionine in patients with autoimmune thyroiditis. European Journal of Endocrinology / European Federation of Endocrine Societies 2003;148(4):389-93. [PUBMED: PMID: 12656658]
Gärtner 2002 {published data only}
  • Gärtner R, Gasnier BC, Dietrich JW, Krebs B, Angstwurm MW. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations. Journal of Clinical Endocrinology and Metabolism 2002;87(4):1687-91. [PUBMED: PMID: 11932302]
Gärtner 2003 {published data only}
Nacamulli 2010 {published data only}
  • Nacamulli D, Mian C, Petricca D, Lazzarotto F, Barollo S, Pozza D, et al. Influence of physiological dietary selenium supplementation on the natural course of autoimmune thyroiditis. Clinical Endocrinology (Oxf) 2010;73(4):535-9. [PUBMED: PMID: 20039895]

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Krysiak 2012 {published data only}
  • Krysiak R, Okopien B. Haemostatic effects of levothyroxine and selenomethionine in euthyroid patients with Hashimoto's thyroiditis. Thrombosis and Haemostasis 2012;108(5):973-80. [PUBMED: PMID: 22918596]

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
EudraCT2007-001107-38 {unpublished data only}
  • EudraCT2007-001107-38. Dose finding study to investigate efficacy and tolerability of a 6 month oral treatment with selenium in patients with autoimmune thyroiditis:prospective, controlled parallel group study with Cefasel versus placebo- double blind, randomised clinical multicentre study of phase II with four treatment groups. [Dosisfindungsstudie zur Untersuchung der Wirksamkeit und Verträglichkeit einer 6-monatigen oralen Selen-Behandlung bei autoimmuner Thyreoiditis: prospektiver, kontrollierter Parallelvergleich von Cefasel versus Placebo- doppelblinde, randomisierte, klinische Multizenterstudie der Phase II mit vier Behandlungsgruppen]. accessed 5 November 2012.
ISRCTN26633557 {unpublished data only}
  • ISRCTN26633557. Selenium supplementation in euthyroid patients with thyroid peroxidase antibodies. accessed 5 November 2012.
NCT01465867 {unpublished data only}
  • NCT01465867. Selenium supplementation in pregnancy (Serena). accessed 5 November 2012.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Bleys 2008
  • Bleys J, Navas-Acien A, Guallar E. Serum selenium levels and all-cause, cancer, and cardiovascular mortality among US adults. Archives of Internal Medicine 2008;168(4):404-10. [PUBMED: PMID: 18299496]
Brown 2001
  • Brown KM, Arthur JR. Selenium, selenoproteins and human health: a review. Public Health Nutrition 2001;4(2B):593-9. [PUBMED: PMID: 11683552]
Brown 2006
Bülow Pedersen 2005
  • Bülow Pedersen I, Laurberg P, Knudsen N, Jørgensen T, Perrild H, Ovesen L, et al. A population study of the association between thyroid autoantibodies in serum and abnormalities in thyroid function and structure. Clinical Endocrinology 2005;62(6):713-20. [PUBMED: PMID: 15943834]
Canaris 2000
Carta 2004
  • Carta MG, Loviselli A, Hardoy MC, Massa S, Cadeddu M, Sardu C, et al. The link between thyroid autoimmunity (antithyroid peroxidase autoantibodies) with anxiety and mood disorders in the community: a field of interest for public health in the future. BMC Psychiatry 2004;18(4):25. [PUBMED: PMID: 15317653]
Chistiakov 2005
  • Chistiakov DA. Immunogenetics of Hashimoto's thyroiditis. Journal of Autoimmune Diseases 2005;2(1):1. [PUBMED: PMID: 15762980]
Dosiou 2012
  • Dosiou C, Barnes J, Schwartz A, Negro R, Crapo L, Stagnaro-Green A. Cost-effectiveness of universal and risk-based screening for autoimmune thyroid disease in pregnant women. Journal of Clinical Endocrinology and Metabolism 2012;97(5):1536-46. [PUBMED: PMID: 22399510]
Drutel 2013
DynaMed 2013
  • Hashimoto thyroiditis. DynaMed [database online] EBSCO Publishing, 2013. Updated August 14, 2012. Accessed January 5, 2013.
Egger 1997
Fatourechi 1971
  • Fatourechi V, McConahey WM, Woolner LB. Hyperthyroidism associated with histologic Hashimoto's thyroiditis. Mayo Clinic Proceedings 1971;46(10):682-9. [PUBMED: PMID: 5171000]
Fink 2010
  • Fink H, Hintze G. Autoimmune thyroiditis (Hashimoto's thyroiditis): current diagnostics and therapy [Die Autoimmunthyreoiditis (Hashimoto-Thyreoiditis): aktuelle Diagnostik und Therapie]. Medizinische Klinik 2010;105(7):485-93.
Goldhaber 2003
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from
Higgins 2011a
  • Higgins JP, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 2011;343:d5928.
Hu 2012
Huber 2002
  • Huber G, Staub JJ, Meier C, Mitrache C, Guglielmetti M, Huber P, et al. Prospective study of the spontaneous course of subclinical hypothyroidism: prognostic value of thyrotropin, thyroid reserve, and thyroid antibodies. Journal of Clinical Endocrinology and Metabolism 2002;87(7):3221-6. [PUBMED: PMID: 12107228]
Hutfless 2011
  • Hutfless S, Matos P, Talor MV, Caturegli P, Rose NR. Significance of prediagnostic thyroid antibodies in women with autoimmune thyroid disease. Journal of Clinical Endocrinology and Metabolism 2011;96(9):E1466-71. [PUBMED: PMID:21715532]
Kirkham 2010
Kraiem 1992
  • Kraiem Z, Baron E, Kahana L, Sadeh O, Sheinfeld M. Changes in stimulating and blocking TSH receptor antibodies in a patient undergoing three cycles of transition from hypo to hyper-thyroidism and back to hypothyroidism. Clinical Endocrinology 1992;36(2):211-4. [PUBMED: PMID: 1637398]
Köhrle 2005
Lazarus 1996
Li 2011
Liberati 2009
Mazokopakis 2007
  • Mazokopakis EE, Papadakis JA, Papadomanolaki MG, Batistakis AG, Giannakopoulos TG, Protopapadakis EE, et al. Effects of 12 months treatment with L-selenomethionine on serum anti-TPO Levels in patients with Hashimoto's thyroiditis. Thyroid 2007;17(7):609-12.
Mitchell 2007
  • Mitchell RN, Kumar V, Abbas AK, Fausto N. The endocrine system. In: Alpers CE, Anthony DC, Aster JC, Crawford JM, Crum CP, et al. editor(s). Robbins and Cotran Pathologic Basis of Disease. 8th Edition. Philadelphia, Pa: Elsevier, 2007:758-60.
Monsen 2000
  • Monsen ER. Dietary reference intakes for the antioxidant nutrients: vitamin C, vitamin E, selenium, and carotenoids. Journal of the American Dietetic Association 2000;100(6):637-40. [PUBMED: PMID: 10863565]
Ott 2011
  • Ott J, Promberger R, Kober F, Neuhold N, Tea M, Huber JC, et al. Hashimoto's thyroiditis affects symptom load and quality of life unrelated to hypothyroidism: a prospective case-control study in women undergoing thyroidectomy for benign goiter. Thyroid 2011;21(2):161-7. [PUBMED: PMID: 21186954]
Pearce 2003
Rayman 2008
RevMan 2011 [Computer program]
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011.
Saranac 2011
  • Saranac L, Zivanovic S, Bjelakovic B, Stamenkovic H, Novak M, Kamenov B. Why is the thyroid so prone to autoimmune disease?. Hormone Research in Paediatrics 2011;75(3):157-65. [PUBMED: PMID: 21346360]
Schulz 1995
  • Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 1995;273(5):408-12. [PUBMED: PMID: 7823387]
Staii 2010
  • Staii A, Mirocha S, Todorova-Koteva K, Glinberg S, Jaume JC. Hashimoto thyroiditis is more frequent than expected when diagnosed by cytology which uncovers a pre-clinical state. Thyroid Research 2010;3(1):11. [PUBMED: PMID: 21172028]
Stathatos 2012
Stranges 2007
  • Stranges S, Marshall JR, Natarajan R, Donahue RP, Trevisan M, Combs GF, et al. Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial. Annals of Internal Medicine 2007;147(4):217-23. [PUBMED: PMID: 17620655]
Stranges 2010
  • Stranges S, Laclaustra M, Ji C, Cappuccio FP, Navas-Acien A, Ordovas JM, et al. Higher selenium status is associated with adverse blood lipid profile in British adults. Journal of Nutrition 2010;140(1):81-7. [PUBMED: PMID: 19906812]
Stuart 2011
Takasu 1990
Tomer 2002
  • Tomer Y. Genetic dissection of familial autoimmune thyroid diseases using whole genome screening. Autoimmunity Reviews 2002;1(4):198-204. [PUBMED: PMID: 12848996]
Toulis 2010
  • Toulis KA, Anastasilakis AD, Tzellos TG, Goulis DG, Kouvelas D. Selenium supplementation in the treatment of Hashimoto's thyroiditis: a systematic review and a meta-analysis. Thyroid 2010;20(10):1163-73. [PUBMED: PMID: 20883174]
Özen 2011
  • Özen S, Berk Ö, Şimşek DG, Darcan S. Clinical course of Hashimoto's thyroiditis and effects of levothyroxine therapy on the clinical course of the disease in children and adolescents. Journal of Clinical Research in Pediatric Endocrinology 2011;3(4):192-7. [PUBMED: PMID: 22155461]