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Intervention Protocol

Treatment for epilepsy in pregnancy: congenital malformation outcomes in the child

  1. Jennifer Pulman1,*,
  2. Rebecca Bromley2,
  3. Naghme Adab3,
  4. Janette Greenhalgh4,
  5. Andrew J McKay5,
  6. Catrin Tudur Smith6,
  7. Rumona C Dickson4,
  8. Anthony G Marson7

Editorial Group: Cochrane Epilepsy Group

Published Online: 14 NOV 2012

DOI: 10.1002/14651858.CD010224

Database Title

Additional Information

How to Cite

Pulman J, Bromley R, Adab N, Greenhalgh J, McKay AJ, Tudur Smith C, Dickson RC, Marson AG. Treatment for epilepsy in pregnancy: congenital malformation outcomes in the child (Protocol). Cochrane Database of Systematic Reviews 2012, Issue 11. Art. No.: CD010224. DOI: 10.1002/14651858.CD010224.

Author Information

  1. 1

    Cochrane Epilepsy Group, Department of Neuroscience, Liverpool, Merseyside, UK

  2. 2

    Clinical Sciences Centre for Research and Education, Department of Neuroscience, Liverpool, UK

  3. 3

    Walsgrave Hospital, University Hospitals Coventry and Warwickshire NHS Trust, Department of Neurology, A5 Corridor, Coventry, Warwickshire, UK

  4. 4

    University of Liverpool, Liverpool Reviews and Implementation Group, Liverpool, UK

  5. 5

    Institute of Child Health, Alder Hey Hospital, Clinical Trials Unit, Liverpool, Merseyside, UK

  6. 6

    University of Liverpool, Centre for Medical Statistics and Health Evaluation, Liverpool, UK

  7. 7

    Institute of Translational Medicine, University of Liverpool, Department of Molecular and Clinical Pharmacology, Liverpool, Merseyside, UK

*Jennifer Pulman, Department of Neuroscience, Cochrane Epilepsy Group, Clinical Sciences Centre, University Hospital Aintree, Lower Lane, Liverpool, Merseyside, L9 7LJ, UK. jennifer.pulman@liv.ac.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 14 NOV 2012

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Abstract

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  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

To assess the effects of prenatal exposure to commonly prescribed AEDs on prevalence of congenital malformations in the child.

It is intended that this review will examine the association between AED exposure and the prevalence of congenital malformations compared to the general population or unexposed pregnancies in women with epilepsy. We also aim to compare the prevalence of congenital malformations following specific monotherapy AED exposure against each other and where possible against classes of polytherapy combinations (e.g. polytherapy including sodium valproate).

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