Treatment for epilepsy in pregnancy: congenital malformation outcomes in the child

  • Protocol
  • Intervention



This is the protocol for a review and there is no abstract. The objectives are as follows:

To assess the effects of prenatal exposure to commonly prescribed AEDs on prevalence of congenital malformations in the child.

It is intended that this review will examine the association between AED exposure and the prevalence of congenital malformations compared to the general population or unexposed pregnancies in women with epilepsy. We also aim to compare the prevalence of congenital malformations following specific monotherapy AED exposure against each other and where possible against classes of polytherapy combinations (e.g. polytherapy including sodium valproate).