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The role of high-frequency oscillations in epilepsy surgery planning

  1. David Gloss1,*,
  2. Sarah J Nolan2,
  3. Richard Staba3

Editorial Group: Cochrane Epilepsy Group

Published Online: 15 JAN 2014

Assessed as up-to-date: 15 APR 2013

DOI: 10.1002/14651858.CD010235.pub2

How to Cite

Gloss D, Nolan SJ, Staba R. The role of high-frequency oscillations in epilepsy surgery planning. Cochrane Database of Systematic Reviews 2014, Issue 1. Art. No.: CD010235. DOI: 10.1002/14651858.CD010235.pub2.

Author Information

  1. 1

    Neurology MC14-05, Danville, USA

  2. 2

    The University of Liverpool, Department of Biostatistics, Liverpool, UK

  3. 3

    University of California, Department of Neurology, Los Angeles, California, USA

*David Gloss, Neurology MC14-05, 100 N Academy Ave, Geisinger Medical Center, Danville, PA 17821, USA.

Publication History

  1. Publication Status: New
  2. Published Online: 15 JAN 2014



References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Modur 2011 {published data only}
RamachandranNair 2008 {published data only}
  • RamachandranNair R, Ochi A, Imai K, Benifla M, Akiyama T, Holowka S, et al. Epileptic spasms in older pediatric patients: MEG and ictal high-frequency oscillations suggest focal-onset seizures in a subset of epileptic spasms. Epilepsy Research 2008;78(2-3):216-24.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Akiyama 2009 {published data only}
  • Akiyama T, Go C, Ochi A, Sugiyama I, Donner EJ, Weiss Sk, et al. Concordance between distribution of interictal fast ripples and resection area may contribute to seizure freedom for epilepsy surgery. Epilepsia 2009;50(S11):448-9, Abstract no: 3.281.
Akiyama 2011 {published data only}
Aubert 2009 {published data only}
  • Aubert S, Wendling F, Regis J, McGonigal A, Figarella-Branger D, Peragut J-C, et al. Local and remote epileptogenicity in focal cortical dysplasias and neurodevelopmental tumors. Brain 2009;132:3072-86.
Bartolomei 2008 {published data only}
Cho 2012 {published data only}
  • Cho JR, Joo EY, Koo DL, Hong SC, Hong SB. Clinical utility of interictal high-frequency oscillations recorded with subdural macroelectrodes in partial epilepsy. Journal of Clinical Neurophysiology 2012;8(1):22-34.
Fujiwara 2012 {published data only}
Guggisberg 2008 {published data only}
  • Guggisberg AG, Kirsch HE, Mantle MM, Barbaro NM, Nagarajan SS. Fast oscillations associated with interictal spikes localize the epileptogenic zone in patients with partial epilepsy. NeuroImage 2008;39:661-8.
Haegelen 2013 {published data only}
  • Haegelen C, Perucca P, Chatillon C-E, Andrade-Valenca L, Zelmann R, Jacobs J, et al. High-frequency oscillations, extent of surgical resection, and surgical outcome in drug-resistant focal epilepsy. Epilepsia 2013;54(15):848-57. DOI: 10.1111/epi.12075.
Jacobs 2010 {published data only}
Kanazawa 2012 {published data only}
  • Kanazawa K, Matsumoto R, Imamura H, Matsuhashi M, Kuneida T, Mikuni N, et al. Are ictal DC shifts and high frequency oscillation complimentary? A study of subdural electrodes in partial epilepsy. Neurology 2012;78(1 Meeting Abstracts):P04.012.
Kerber 2013 {published data only}
Khosravani 2009 {published data only}
Kobayashi 2011 {published data only}
Lemesiou 2012 {published data only}
  • Lemesiou A, Walker MC, Rodionov R, Diehl B, Rugg-Gunn F. The utility of high frequency oscillations on MEG and intracranial EEG in localizing seizure foci in patients with refractory epilepsy. Epilepsia 2012;53(S5):198.
Matsumoto 2013 {published data only}
  • Matsumoto A, Brinkmann BH, Stead SM, Matsumoto J, Kucewicz M, Marsh WR, et al. Pathological and physiological high frequency oscillations in focal human epilepsy. Journal of Neurophysiology 110;8:1958-64.
Miocinovic 2012 {published data only}
  • Miocinovic S, Modur P. Interictal versus ictal high frequency oscillation in neocortical epilepsy. Neurology 2012;78(1_Meeting Abstracts):PD3.007.
Modur 2012 {published data only}
  • Modur PN, Vitaz TW, Zhang S. Seizure localization using broadband EEG: comparison of conventional frequency activity, high-frequency oscillations, and infraslow activity. Journal of Clinical Neurophysiology 2012;29(4):309-19.
Mohamed 2012 {published data only}
  • Mohamed AR, Bailed CA, Freeman JL, Maixner W, Jackson GD, Harvey AS. Intrinsic epileptogenicity of cortical tubers revealed by intracranial monitoring. Neurology 2012;79:2249-57.
Nariai 2011 {published data only}
Nowacki 2012 {published data only}
  • Nowacki T, Gross D, Wheatley B, Ahmed SN, Jirsch J. The location of fast ripples is stationary as focal seizures evolve. Epilepsia 2012;53(S5):198.
Ochi 2007 {published data only}
Park 2012 {published data only}
  • Park S-C, Lee SK, Che H, Chung CK. Ictal high-gamma oscillation (60-99 Hz) in intracranial electroencephalography and postoperative seizure outcome in neocortical epilepsy. Clinical Neurophysiology 2012;123(6):1100-10.
Pearce 2013 {published data only}
  • Pearce A, Wulsin D, Blanco JA, Krieger A, Litt B, Stacey WC. Temporal changes of neocortical high-frequency oscillations in epilepsy. Journal of Neurophysiology 2013;110:1167-79.
Ramp 2013 {published data only}
  • Ramp S, Schmitt HJ, Heers M, Schonherr M, Schmitt FC, Hopfengartner R, Stefan H. Etomidate activates epileptic high frequency oscillations. Clinical Neurophysiology [in press].
Ray 2008 {published data only}
  • Ray S, Niebur E, Hasiao, Sinai A, Crone NE. High-frequency gamma activity (80-150 Hz) is increased in human cortex during selective attention. Clinical Neurophysiology 2008;119:116-33.
Schindler 2010 {published data only}
  • Schindler K, Amor F, Gast H, Muller M, Stibal A, Mariani L, Rummel C. Peri-ictal correlation dynamics of high-frequency (80-200 Hz) intracranial EEG. Epilepsy Research 2010;89:72-81.
Smart 2011 {published data only}
  • Smart O, Tsoulos IG, Gavrilis D, Georgoulas G. Grammatical evolution for features of epileptic oscillations in clinical intracranial electroencephalograms. Expert Systems with Applications 2011;38:9991-9.
Stamoulis 2012 {published data only}
  • Stamoulis C, Gruber LJ, Schomer DL, Chang BS. High-frequency neuronal network modulations encoded in scalp EEG precede the onset of focal seizures. Epilepsy & Behavior 2012;23:471-80.
Stamoulis 2013 {published data only}
  • Stamoulis C, Schomer DL, Chang BS. Information theoretic measures of network coordination in high-frequency scalp EEG reveal dynamic patterns associated with seizure termination. Epilepsy Research 2013;105:299-315.
Usui 2011 {published data only}
  • Usui N, Terada K, Baba K, Matsua K, Nakamura F, Usui K, et al. Clinical significance of ictal high frequency oscillations in medial temporal lobe epilepsy. Clinical Neurophysiology 2011;122:1693-700.
van't Klooster 2011 {published data only}
  • van't Klooster MA, Zijlmans M, Leijten FSS, Ferrier CH, van Putten MJAM, Huiskamp GJM. Time-frequency analysis of single pulse electrical stimulation to assist delineation of epileptogenic cortex. Brain 2011;134:2855-66.
van Diessen 2013 {published data only}
  • van Diessen E, Hanemaaijer JI, Otte WM, Zelmann R, Jacobs J, Jansen FE, et al. Are high frequency oscillations associated with altered network topology in partial epilepsy. NeuroImage 2013;82:564-73.
Wang 2013 {published data only}
Wetjen 2009 {published data only}
  • Wetjen NM, Marsh WR, Meyer FB, Cascino GD, So E, Britton JW, et al. Intracranial electroencephalography seizure onset patterns and surgical outcomes in non lesional extratemporal epilepsy. Journal of Neurosurgy 2009;110:1147-52.
Wu 2012 {published data only}
  • Wu S, Luders H. Direct current (DC) shifts and high frequency oscillations in mesial temporal lobe epilepsy patients. Neurology 2012;78(1_Meeting Abstracts):P04.013.
Wu JY 2010 {published data only}
  • Wu JY, Sankar R, Lerner JT, Matsumoto JH, Vinters HV, Mathern GW. Removing interictal fast ripples on electrocorticography linked with seizure freedom in children. Neurology 2010;75:1686-94.
Wu M 2010 {published data only}
  • Wu M, Wineski K, Schalk G, Sharma M, Roland J, Breshears J, et al. Electrocorticographic frequency alteration mapping for extraoperative localization of speech cortex. Neurosurgery 2010;66:E407-9.
Zijlmans 2012 {published data only}

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Annegers 1999
Bautista 1999
Berg 2003
Berg 2006
Bragin 2000
Bragin 2010
Engel 1993
  • Engel J. Surgical Treatment of Epilepsies. 2nd Edition. Philadelphia, PA: Lippincott, Williams, and Wilkins, 1993.
Engel 2003
Engel 2009
Hauser 1993
Hennessy 2001
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions, version 5.1.0 [updated March 2011]. The Cochrane Collaboration. Available from
Hirtz 2007
Jacobs 2008
Jacobs 2010
Jehi 2009
Jirsch 2006
Juul-Jenson 1983
Khosravani 2009
Kirkham 2010
  • Kirkham JJ, Dwan KM, Altman DG, Gamble C, Dodd S, Smyth R, et al. The impact of outcome reporting bias in randomised controlled trials on a cohort of systematic reviews. BMJ 2010;340:c365.
Kwan 2000
Kwan 2010
MacDonald 2000
Mathern 2007
  • Mathern GW, Sperling M. Presurgical evaluation: general principles and methods. In: Engel J, Pedley TA editor(s). Epilepsy: A Comprehensive Textbook. 2nd Edition. Philadelphia, PA: Lippincott, Williams & Wilkins, 2007:1771-8.
Mohanraj 2006
Murray 1994
  • Murray CJL, Lopez AD. Global Comparative Assessments in the Health Sector. Geneva: World Health Organization, 1994.
Ngugi 2010
Ogren 2009
Olafsson 2005
  • Olafsson E, Ludvigsson P, Gudmundsson G, Hesdorfer D, Kjartansson O, Hauser WA. Incidence of unprovoked seizures and epilepsy in Iceland and assessment of the epilepsy syndrome classification: a prospective study. Lancet Neurology 2005;4:627-34.
RevMan 2011 [Computer program]
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan) Version 5.1.. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011.
Shadish 2002
  • Shadish WR, Cook TD, Campbell DT. Experimental and Quasi-Experimental Designs for Generalized Causal Inference. Boston. MA: Houghton Mifflin, 2002.
Staba 2004
Staba 2011
Wiebe 2001
Wiser 2001
  • Wiser HG, Blume WT, Fish D, Goldensohn E, Hufnagel A, King D, et al. Proposal for a new classification of outcome with respect to epileptic seizures following epilepsy surgery. Epilepsia 2001;42(2):282-6.
Worrell 2004
Worrell 2008
  • Worrell GA, Gardner AB, Stead SM, Hu S, Goerss S, Cascino GJ, et al. High-frequency oscillations in human temporal lobe: simultaneous microwire and clinical macroelectrode recordings. Brain 2008;131:928-37.
Wu 2010
  • Wu JY, Sankar R, Lerner JT, Matsumoto JH, Vinters HV, Mathern GW. Removing interictal fast ripples on electrocorticography linked with seizure freedom in children. Neurology 2010;75:1686-94.