Higher versus lower oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth
Editorial Group: Cochrane Neonatal Group
Published Online: 14 NOV 2012
Copyright © 2013 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
How to Cite
Lui K, Foster JP, Davis PG, Ching SK, Oei JL, Osborn DA. Higher versus lower oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth (Protocol). Cochrane Database of Systematic Reviews 2012, Issue 11. Art. No.: CD010239. DOI: 10.1002/14651858.CD010239.
- Publication Status: Edited (no change to conclusions)
- Published Online: 14 NOV 2012
This is the protocol for a review and there is no abstract. The objectives are as follows:
To determine whether higher or lower initial oxygen concentrations then titrated according to oxygen saturation targeting during the resuscitation of preterm infants at birth lead to improved short and long term mortality and morbidity.
- Any of the lower concentrations of oxygen (21%, air, > 21% to 29% (very low); ≥ 30% to 39% (low)) versus any of the higher concentrations of oxygen (≥ 40% to 59% (high); ≥ 60% to 100% (very high)).
The primary comparison will be analysed in subgroups within the same analysis. We plan to carry out the following subgroup analyses:
- targeted oxygen saturation (low or high upper target limit for titration, < 85%; 85% to 90%; 91% to 95%; > 95%);
- type of oxygen saturation monitor (fractional or functional oxygen saturation);
- gestation (< 28 weeks; 28 weeks to 32 weeks; 33 weeks to 36 weeks).
Studies that compare two oxygen concentrations that may considered to be either in the lower or the higher ranges will not be included in the primary analyses. Secondary analyses will be performed for these studies that compare two groups both in the lower, or higher, oxygen concentration range (for example 50% versus 100%).