Intervention Protocol

Higher versus lower oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth

  1. Kei Lui1,*,
  2. Jann P Foster2,3,
  3. Peter G Davis4,
  4. See Kwee Ching5,
  5. Ju Lee Oei6,
  6. David A Osborn7

Editorial Group: Cochrane Neonatal Group

Published Online: 14 NOV 2012

DOI: 10.1002/14651858.CD010239


How to Cite

Lui K, Foster JP, Davis PG, Ching SK, Oei JL, Osborn DA. Higher versus lower oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth (Protocol). Cochrane Database of Systematic Reviews 2012, Issue 11. Art. No.: CD010239. DOI: 10.1002/14651858.CD010239.

Author Information

  1. 1

    Royal Hospital for Women, Department of Newborn Care, Randwick, New South Wales, Australia

  2. 2

    University of Western Sydney, School of Nursing & Midwifery, Sydney, NSW, Australia

  3. 3

    University of Sydney, Central Clinical School, Discipline of Obstetrics, Gynaecology and Neonatology,Sydney Medical School/Sydney Nursing School, Sydney, NSW, Australia

  4. 4

    The Royal Women's Hospital, Department of Newborn Research, Parkville, Victoria, Australia

  5. 5

    Royal Hospital for Women, Newborn Care Centre, Randwick, Sydney, Australia

  6. 6

    The Royal Women's Hospital, Department of Newborn Care, Randwick, NSW, Australia

  7. 7

    University of Sydney, Central Clinical School, Discipline of Obstetrics, Gynaecology and Neonatology, Sydney, NSW, Australia

*Kei Lui, Department of Newborn Care, Royal Hospital for Women, Barker Street, Randwick, New South Wales, 2031, Australia. k.lui@unsw.edu.au.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 14 NOV 2012

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

To determine whether higher or lower initial oxygen concentrations then titrated according to oxygen saturation targeting during the resuscitation of preterm infants at birth lead to improved short and long term mortality and morbidity.

Primary comparison

  • Any of the lower concentrations of oxygen (21%, air, > 21% to 29% (very low); ≥ 30% to 39% (low)) versus any of the higher concentrations of oxygen (≥ 40% to 59% (high); ≥ 60% to 100% (very high)).

The primary comparison will be analysed in subgroups within the same analysis. We plan to carry out the following subgroup analyses:

  • targeted oxygen saturation (low or high upper target limit for titration, < 85%; 85% to 90%; 91% to 95%; > 95%);

  • type of oxygen saturation monitor (fractional or functional oxygen saturation);

  • gestation (< 28 weeks; 28 weeks to 32 weeks; 33 weeks to 36 weeks).

Secondary analyses

Studies that compare two oxygen concentrations that may considered to be either in the lower or the higher ranges will not be included in the primary analyses. Secondary analyses will be performed for these studies that compare two groups both in the lower, or higher, oxygen concentration range (for example 50% versus 100%).