Intervention Review

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Transdermal fentanyl for cancer pain

  1. Gina Hadley1,*,
  2. Sheena Derry2,
  3. R Andrew Moore2,
  4. Philip J Wiffen2

Editorial Group: Cochrane Pain, Palliative and Supportive Care Group

Published Online: 5 OCT 2013

Assessed as up-to-date: 3 SEP 2013

DOI: 10.1002/14651858.CD010270.pub2

How to Cite

Hadley G, Derry S, Moore RA, Wiffen PJ. Transdermal fentanyl for cancer pain. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD010270. DOI: 10.1002/14651858.CD010270.pub2.

Author Information

  1. 1

    University of Oxford, Pain Research and Nuffield Department of Clinical Neurosciences, Oxford, Oxfordshire, UK

  2. 2

    University of Oxford, Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), Oxford, Oxfordshire, UK

*Gina Hadley, Pain Research and Nuffield Department of Clinical Neurosciences, University of Oxford, Pain Research Unit, Churchill Hospital, Oxford, Oxfordshire, OX3 7LE, UK.

Publication History

  1. Publication Status: Stable (no update expected for reasons given in 'What's new')
  2. Published Online: 5 OCT 2013



References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Ahmedzai 1997 {published data only}
Kongsgaard 1998 {published data only}
Kress 2008 {published data only}
Mercadante 2008 {published data only}
Mystakidou 2005 {published data only}
  • Mystakidou K, Katsouda E, Kouloulias V, Kouvaris J, Tsiatas M, Vlahos L. Comparison of transdermal fentanyl with codeine/paracetamol, in combination with radiotherapy, for the management of metastatic bone pain. Journal of Opioid Management 2005;1(4):204-10. [2959068]
Oztürk 2008 {published data only}
  • Oztürk T, Karadibak K, Catal D, Cakan A, Tugsavul F, Cirak K. Comparison of TD-fentanyl with sustained-release morphine in the pain treatment of patients with lung cancer. Agri 2008;20(3):20-5. [2959070]
Pistevou-Gompaki 2004 {published data only}
  • Pistevou-Gompaki K, Kouloulias VE, Varveris C, Mystakidou K, Georgakopoulos G, Eleftheriadis N, et al. Radiotherapy plus either transdermal fentanyl or paracetamol and codeine for painful bone metastases: a randomised study of pain relief and quality of life. Current Medical Research and Opinion 2004;20(2):159-63. [2959072; DOI: 10.1185/030079903125002829]
van Seventer 2003 {published data only}
Wong 1997 {published data only}
  • Wong JO, Chiu GL, Tsao CJ, Chang CL. Comparison of oral controlled-release morphine with transdermal fentanyl in terminal cancer pain. Acta Anaesthesiologica Sinica 1997;35(3):25-32. [2959076]

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Ergenoglu 2010 {published data only}
  • Ergenoglu P, Ozbek H, Gunduz M, Isik G. Comparison of the analgesic efficacy of intravenous morphine infusion and transdermal fentanyl in oncology patients with mucositis [Mukozitli onkoloji hastalarinda intravenoz morfin infuzyonu ve transdermal fentanilin analjezik etkinliginin karsilastirilmasi]. Anatolian Journal of Clinical Investigation 2010;4(3):134-40. [2959078]
Sarhan 2009 {published data only}
  • Sarhan T, Doghem M. A comparison of two trans-dermal drug delivery systems; buprenorphine and fentanyl for chronic cancer pain management. European Journal of Pain. 6th Congress of the European Federation of IASP Chapters: Pain in Europe 6th, EFIC Lisbon Portugal. 2009; Vol. 13:S199. [2959080]
Wirz 2009 {published data only}

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Cachia 2011
Cancer Research UK
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Cleary 2007
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Hadley 2009
  • Hadley G, Derry S, Moore RA, Wee B. Can observational studies provide a realistic alternative to randomized controlled trials in palliative care?. Journal of Pain & Palliative Care Pharmacotherapy 2009;23(2):106-13. [DOI: 10.1080/15360280902899921]
Heiskanen 2009
Higgins 2011
  • Altman DG, Antes G, Gøtzsche P, Higgins JPT, Jüni P, Lewis S, et al. Assessing risk of bias in included studies. In: Higgins JPT, Altman DG, Sterne JAC editor(s). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 (updated March 2011). Available from The Cochrane Collaboration, 2011.
Jadad 1996
Jeal 1997
Kornick 2003
Koyyalagunta 2012
  • Koyyalagunta D, Bruera E, Solanki DR, Nouri KH, Burton AW, Toro MP, et al. A systematic review of randomized trials on the effectiveness of opioids for cancer pain. Pain Physician 2012;15(3 Suppl):ES39-58.
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Moore 1982
  • Moore RA, Bullingham RE, McQuay HJ, Hand CW, Aspel JB, Allen MC, et al. Dural permeability to narcotics: in vitro determination and application to extradural administration. British Journal of Anaesthetics 1982;54(10):1117-28.
Moore 1998
Moore 2010
  • Moore RA, Moore OA, Derry S, Peloso PM, Gammaitoni AR, Wang H. Responder analysis for pain relief and numbers needed to treat in a meta-analysis of etoricoxib osteoarthritis trials: bridging a gap between clinical trials and clinical practice. Annals of the Rheumatic Diseases 2010;69(2):374-9. [DOI: 10.1136/ard.2009.107805]
Morris 1995
  • Morris JA, Gardner MJ. Calculating confidence intervals for relative risk, odds ratios and standardised ratios and rates. In: Gardner MJ, Altman DG editors editor(s). Statistics with Confidence - Confidence Intervals and Statistical Guidelines. London: BMJ Books, 1995:50-63.
Muijsers 2001
RevMan 2011
  • The Nordic Cochrane Centre. The Cochrane Collaboration. Review Manager (RevMan). 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011.
Tassinari 2008
  • Tassinari D, Sartori S, Tamburini E, Scarpi E, Raffaeli W, Tombesi P, et al. Adverse effects of transdermal opiates treating moderate-severe cancer pain in comparison to long-acting morphine: a meta-analysis and systematic review of the literature. Journal of Palliative Medicine 2008;11(3):492-501. [DOI: 10.1089/jpm.2007.0200]
Tassinari 2011
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Wiffen 2013