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Intervention Protocol

Non-surgical interventions for human papilloma virus-positive local advanced oropharyngeal squamous cell cancer

  1. Liam Masterson1,*,
  2. Daniel Moualed2,
  3. Ajmal Masood3,
  4. Richard Benson4,
  5. Jane C Sterling5,
  6. Holger Sudhoff6,
  7. Piyush Jani1,
  8. Peter Goon7

Editorial Group: Cochrane Ear, Nose and Throat Disorders Group

Published Online: 12 DEC 2012

DOI: 10.1002/14651858.CD010271

How to Cite

Masterson L, Moualed D, Masood A, Benson R, Sterling JC, Sudhoff H, Jani P, Goon P. Non-surgical interventions for human papilloma virus-positive local advanced oropharyngeal squamous cell cancer (Protocol). Cochrane Database of Systematic Reviews 2012, Issue 12. Art. No.: CD010271. DOI: 10.1002/14651858.CD010271.

Author Information

  1. 1

    Cambridge University Hospitals NHS Foundation Trust, ENT Department, Cambridge, UK

  2. 2

    Great Western Hospitals NHS Foundation Trust, ENT Department, Swindon, UK

  3. 3

    Norfolk and Norwich University Hospital, ENT Department, Norwich, UK

  4. 4

    Addenbrooke's Hospital, Oncology Centre, Cambridge, UK

  5. 5

    Addenbrooke's Hospital, Department of Dermatology, Cambridge, UK

  6. 6

    Bielefeld Academic Teaching Hospital, Department of Otolaryngology, Head and Neck Surgery, Bielefeld, Germany

  7. 7

    University of Cambridge, Department of Pathology, Cambridge, UK

*Liam Masterson, ENT Department, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK. lmm398@doctors.org.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 12 DEC 2012

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

Primary objective

To determine which treatment regimen (that must include one or more of chemotherapy, radiotherapy or biotherapy) given with the intention to cure HPV-positive local advanced oropharyngeal squamous cell cancer will lead to the best outcomes in terms of overall survival, treatment-related morbidity and side effects. Comparison will be drawn between treatment regimens that have different therapeutic agents, dosing or delivery methods.

Secondary objective

To determine the implications of treatment modalities in terms of quality of life, disease-free survival and costs.